Effects of zinc on expression of apoptosis-related genes in freezing thawing damage of adipose tissue derived mesenchymal stromal cells

Nesari, Fatemeh; Gholami, Mohammadreza; Rezaian, Jafar; Pirnia, Afshin; Anbari, Khatereh; Boroujeni, Masoud Beigi; Boroujeni, Mandana Beigi

doi:10.1080/10826068.2021.1983830

Cited by 1 publication

(1 citation statement)

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“… 76 On the other hand, zinc is involved in proliferation and apoptosis and consistent with the finding of the current work, zinc alone increased the expression of Bcl2. 77 However, the combination groups lowered the expression of Bcl2. This modulatory effect could be the reason behind decreasing the neuropathic pain and may explain the neuroprotection achieved by this combination.…”

Section: Discussionmentioning

confidence: 98%

The Combination of Zinc and Melatonin Enhanced Neuroprotection and Attenuated Neuropathy in Oxaliplatin-Induced Neurotoxicity

Ali¹,

Aziz²

2022

DDDT

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Objective The present study was designed to investigate the possible synergistic effects of melatonin with zinc in the prevention and treatment of oxaliplatin-induced neurotoxicity in rats. Methodology Forty-eight male Wistar albino rats were used and randomly allocated into six groups: The negative control group, oxaliplatin group, zinc + oxaliplatin group, melatonin + oxaliplatin group, zinc + melatonin + oxaliplatin prevention-approach group, and zinc + melatonin + oxaliplatin treatment-approach group. The thermal nociceptive/hyperalgesia tests were performed. Brain tissue homogenate was used for measuring GFAP, NCAM, TNF α, MAPK 14, NF-kB, GPX, and SOD. Brain tissue was sent for histopathological and immunohistochemistry studies. Results The combination therapies showed improvement in the behavioral tests. A significant increase in GPX and SOD with a significant decrease in GFAP levels resulted in the prevention approach. TNF α decreased significantly in the treatment approach. No significant changes were seen in NCAM, NFkB, and MAPK-14. The histopathological findings support the biochemical results. Additionally, immunohistochemistry revealed a significant attenuation of p53 and a non-significant decrease in Bcl2 levels in the combination groups. Conclusion The combination of zinc with melatonin for the prevention approach was effective in attenuating neurotoxicity induced by oxaliplatin. The proposed mechanisms are boosting the antioxidant system and attenuating the expression of p53, GFAP, and TNF-α.

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Section: Discussionmentioning

confidence: 98%