Effects of Zinc Methionine Hydroxy Analog Chelate on Laying Performance, Serum Hormone Levels, and Expression of Reproductive Axis Related Genes in Aged Broiler Breeders

Abstract

Inorganic zinc (Zn) supplements are commonly used in poultry feeds, but their low utilization results in the increase of Zn excretion. Thus, to provide a new perspective for the substitution of inorganic Zn, a novel Zn methionine hydroxy analog chelate (Zn-MHA) was studied in the present study to evaluate its effects on laying performance, serum hormone indexes and reproductive axis-related genes in broilers breeders. A total of 480 Hubbard breeders (56-week-old) were fed a basal diet (containing 27.81 mg Zn/kg) without Zn addition for 2 weeks, and then allocated to 4 groups with 6 replicates (each replicate consisting of 10 cages and 2 breeders per cage) for 10 weeks. Four treatment diets given to broiler breeders included the basal diet added with 25, 50, and 75 mg/kg of Zn-MHA and 100 mg/kg of Zn sulfate (ZnSO4). The laying rate, egg weight and feed conversation ratio increased in the 75 mg/kg Zn-MHA group compared to the ZnSO4 group. The eggshell thickness was not decreased with the addition of 50 mg/kg and 75 mg/kg Zn-MHA in the diet compared to the 100 mg/kg ZnSO4 group. There was a significant improvement in the reproductive performance of breeders in the 75 mg/kg Zn-MHA group, including the fertility and 1-day-old offspring weight. Besides, serum sex hormone levels including FSH and P4 increased significantly in 75 mg/kg Zn-MHA group. No significant effect on the ovarian weight or the number of follicles in broiler breeders was observed by supplementing Zn-MHA. Compared to the 100 mg/kg ZnSO4 group, dietary supplementation with 75 mg/kg of Zn-MHA showed an up-regulation of the FSHR mRNA in the granular layer of follicles. However, dietary supplementation of Zn-MHA had no effects on mRNA expressions of the ovarian LHR and PRLR genes. These findings reinforce the suggestion that Zn-MHA (75 mg/kg) could replace ZnSO4 (100 mg/kg) as a Zn supplement in diet of broiler breeders, which resulted in better laying and reproduction performances by regulating the expression levels of reproductive axis related genes and serum hormone levels.

Effects of Dietary Valine Chelated Zinc Supplementation on Growth Performance, Antioxidant Capacity, Immunity, and Intestine Health in Weaned Piglets

“…The improvement in growth performance may be related to the promotion of rapid proliferation of taste bud cells in tongue mucosa by zinc, thus prolonging the residence time of the feed in the digestive tract, improving the secretion of the digestive system, and increasing the activity of enzymes in tissue cells [ 19 , 20 ]. In addition, the supplementation of 75 mg/kg zinc methionine hydroxy analog chelate increased the laying rate and egg weight and decreased the FCR of aged broiler breeders [ 21 ]. In the present study, we demonstrated that the supplementation of 75–100 mg/kg ZnVal improved ADG on days 15–28 and dietary 50–100 mg/kg ZnVal supplementation increased ADG on days 1–28 compared with CON, but had no effect on final BW, ADFI, and FCR of weaned piglets.…”

Effects of dietary valine chelated zinc supplementation on growth performance, antioxidant capacity, immunity, and intestine health in weaned piglets

“…The improvement in growth performance may be related to the promotion of rapid proliferation of taste bud cells in tongue mucosa by zinc, thus prolonging the residence time of the feed in the digestive tract, improving the secretion of the digestive system and increasing the activity of enzymes in tissue cells [19,20]. In addition, the supplementation of 75 mg/kg zinc methionine hydroxy analog chelate increased the laying rate, egg weight and decrease FCR of aged broiler breeders [21]. In the present study, we demonstrated that the supplementation of 75-100 mg/kg ZnVal improved ADG on days 15-28 and dietary 50-100 mg/kg ZnVal supplementation increased ADG on days 1-28 compared with CON, but had no effect on nal BW, ADFI, and FCR of weaned piglets.…”

Efecto del fármaco metformina sobre los niveles de zinc y magnesio en mujeres con síndrome de ovario poliquístico

“…They attributed their result that after metformin intake the glycemic index is improved in their patients which may lead to decrease excretion of urinary zinc. However, in our study, the two groups of patients showed no significant difference in insulin sensitivity (HOMA-IR), which may explain the insignificant difference in zinc levels between the two groups There is a direct correlation between zinc and estrogen in both groups and it is significant in polycystic ovarian patients not on metformin (table2), this may be due to the estrogen decreasing zinc release from the kidney 36 , or zinc may increase estrogen secretion from the suprarenal gland 37 , another opinion is that zinc may up-regulate ovarian FSH receptors to increase estrogen production 38 . However, the antioxidant activity of zinc may have a role in decreasing inflammatory reactions in pelvic region and enhancing ovarian function…”