Effects of zinc chloride on gastric secretion and ulcer formation in pylorus-occluded rats

Zinc ions upregulate the hormone gastrin via an E-box motif in the proximal gastrin promoter

“…What does our finding that gastrin is induced by Zn 2C ions imply about normal gastric physiology? The relationship between Zn 2C ions and gastric acidity is unclear as Zn 2C ions have been reported to either increase (Yamaguchi et al 1980) or reduce gastric acid secretion (Cho et al 1976, Kirchhoff et al 2011. Our observation that treatment with Zn 2C increases both intracellular and secreted Gamide in the gastric carcinoma cell line AGS, if replicated in antral G cells, would result in a CCK2R-mediated increase in gastric acid secretion.…”

Anti-Inflammatory Activity and Gastric Lesions Induced by Zinc-Tenoxicam

“…Although eicosanoids, mainly prostaglandins, are clearly involved in the mechanisms that protect the gastric mucosa against an acidic environment, the mucosal protection conferred by zinc compounds does not seem to be exclusively related to these autacoids, but also to the enhancement of mucus secretion [12,22], changes of the mucus composition [12], maintenance of gastric barrier integrity [10], stabilization of lysosomal membranes, and inhibition of mast cell degranulation [23,24]. If the protection conferred by zinc when it is complexed with tenoxicam also involves similar mechanisms is not clear.…”

In vitroandin vivoimmunomodulatory and anti-ulcerogenic activities ofTeucrium ramosissimumextracts

“…Such findings would be consistent with those by SouzaFormigoni et al (1991) and by Antônio and Souza-Brito (1998) who each compared the anti-ulcerogenic activity of lyophilized infusions of, respectively, M. ilicilifolia and M. qualifolium and of Turnera ulmifolia to that of cimetidine, In each case, the precise mechanisms underlying the observed protective effects of those natural products remains unresolved. It has been suggested by others that agents (potentially tannins, polyphenols, and/or flavonoids) impart a measure of gastric mucosa protection through effects on prostaglandin formation (Rainsford, 1989), inhibition of mast cell degranulation (Cho et al, 1976) or proton pumps (Bossolani, 2000), and/or stabilization of lysosomal membranes (Pfeiffer et al, 1987). Ongoing studies in our laboratories seek to more precisely define the mechanisms -as well as the causative agent(s) -through which our T. ramosissimum extracts imparted their anti-ulcerogenic effects in situ.…”