Effects of zearalenone, α-zearalenol, and genistein on boar sperm motility in vitro

Krejcárková, A.; Folková, Petra; Šimoník, Ondřej; ŠAŠKOVÁ, Martina; Krejčířová, Romana; Drábek, Ondřej; Rajmon, Radko

doi:10.17221/19/2017-cjas

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…Similar to estradiol, ZEA has been shown to exert negative effects on sperm cell, Sertoli cells, and Leydig cells. These include altered concentration, viability, motility, DNA integrity and apoptotic rate of sperm cells; such altered biological functions and apoptotic rates of Sertoli and Leydig cells have been reported in several model systems [ 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ]. These processes are also manifested in altered structure of seminiferous tubules and weight of the testis [ 49 , 50 ].…”

Section: Overview Of the Pathogenesis Of Zearalenonementioning

confidence: 99%

Estrogenic and Non-Estrogenic Disruptor Effect of Zearalenone on Male Reproduction: A Review

Balló

Székvári²,

Czétány

et al. 2023

IJMS

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According to some estimates, at least 70% of feedstuffs and finished feeds are contaminated with one or more mycotoxins and, due to its significant prevalence, both animals and humans are highly likely to be exposed to these toxins. In addition to health risks, they also cause economic issues. From a healthcare point of view, zearalenone (ZEA) and its derivatives have been shown to exert many negative effects. Specifically, ZEA has hepatotoxicity, immunotoxicity, genotoxicity, carcinogenicity, intestinal toxicity, reproductive toxicity and endocrine disruption effects. Of these effects, male reproductive deterioration and processes that lead to this have been reviewed in this study. Papers are reviewed that demonstrate estrogenic effects of ZEA due to its analogy to estradiol and how these effects may influence male reproductive cells such as spermatozoa, Sertoli cells and Leydig cells. Data that employ epigenetic effects of ZEA are also discussed. We discuss literature data demonstrating that reactive oxygen species formation in ZEA-exposed cells plays a crucial role in diminished spermatogenesis; reduced sperm motility, viability and mitochondrial membrane potential; altered intracellular antioxidant enzyme activities; and increased rates of apoptosis and DNA fragmentation; thereby resulting in reduced pregnancy.

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Section: Overview Of the Pathogenesis Of Zearalenonementioning

confidence: 99%

Estrogenic and Non-Estrogenic Disruptor Effect of Zearalenone on Male Reproduction: A Review

Balló

Székvári²,

Czétány

et al. 2023

IJMS

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“…ZEA is often associated with reproductive disorders in livestock (e.g., pigs, cattle, and sheep) and occasionally exerts hyper-estrogenic syndrome in humans [ 91 ]. Recently, ZEA reproductive toxicity has been demonstrated in vitro on boar semen [ 78 , 92 ] and in vivo on rats [ 42 ], or model organism Artemia francisacana [ 93 ]. The estrogenic effect has been observed in vitro on human endometrial cancer (Ishikawa) cells [ 94 ].…”

Section: The Most Significant Mycotoxins In Milk Thistle-based Diementioning

confidence: 99%

Presence of Mycotoxins in Milk Thistle (Silybum marianum) Food Supplements: A Review

Pickova

Ostrý

Toman

et al. 2020

Toxins

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The consumption of herbal-based supplements, which are believed to have beneficial effects on human health with no side effects, has become popular around the world and this trend is still increasing. Silybum marianum (L.) Gaertn, commonly known as milk thistle (MT), is the most commonly studied herb associated with the treatment of liver diseases. The hepatoprotective effects of active substances in silymarin, with silybin being the main compound, have been demonstrated in many studies. However, MT can be affected by toxigenic micro-fungi and contaminated by mycotoxins with adverse effects. The beneficial effect of silymarin can thus be reduced or totally antagonized by mycotoxins. MT has proven to be affected by micro-fungi of the Fusarium and Alternaria genera, in particular, and their mycotoxins. Alternariol-methyl-ether (AME), alternariol (AOH), beauvericin (BEA), deoxynivalenol (DON), enniatin A (ENNA), enniatin A1 (ENNA1), enniatin B (ENNB), enniatin B1 (ENNB1), HT-2 toxin (HT-2), T-2 toxin (T-2), tentoxin (TEN), and zearalenone (ZEA) seem to be most significant in MT-based dietary supplements. This review focuses on summarizing cases of mycotoxins in MT to emphasize the need for strict monitoring and regulation, as mycotoxins in relation with MT-based dietary supplements are not covered by European Union legislation.

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Occurrence and toxicity of a fusarium mycotoxin, zearalenone

Rai

Das

Tripathi

2019

Critical Reviews in Food Science and Nutrition

229

126

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Effects of zearalenone, α-zearalenol, and genistein on boar sperm motility in vitro

Cited by 3 publications

References 28 publications

Estrogenic and Non-Estrogenic Disruptor Effect of Zearalenone on Male Reproduction: A Review

Estrogenic and Non-Estrogenic Disruptor Effect of Zearalenone on Male Reproduction: A Review

Presence of Mycotoxins in Milk Thistle (Silybum marianum) Food Supplements: A Review

Occurrence and toxicity of a fusarium mycotoxin, zearalenone

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