Effects of yohimbine and idazoxan on motor behaviors in male rats

Bowes, Mark P.; Peters, Ronald H.; Kernan, W.J.; Hopper, David L.

doi:10.1016/0091-3057(92)90216-3

Cited by 12 publications

(5 citation statements)

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“…In line with other studies, YOH inhibited locomotor activity [51,52]. It is important to emphasize that inhibitory or stimulatory drug actions on ambulation do not necessarily impact sexual behavior in the same direction.…”

Section: Discussionsupporting

confidence: 88%

The Antidepressants Fluoxetine and Bupropion Differentially Affect Proceptive Behavior in the Naturally Cycling Female Rat

Ventura-Aquino

Fernández‐Guasti

2013

The Journal of Sexual Medicine

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Introduction Fluoxetine, like other selective serotonin reuptake inhibitors, inhibits women's sexual desire and female rats' sexual behavior. Bupropion produces pro-sexual effects in women with and without depression, and yohimbine increases men's and male rats' sexual motivation, but their effects on female rats' proceptivity are unknown. Aim To investigate the effects of fluoxetine, bupropion, and yohimbine on proceptivity and receptivity in the naturally cycling female rat. Methods We studied the effect of chronic (minimum 14 days) fluoxetine (1.25 mg/kg, subcutaneous) and bupropion (5 mg/kg, intraperitoneal) and acute yohimbine (1 mg/kg, intraperitoneal) on sexual behavior of female rats selected in natural proestrus during an ejaculatory series. We also analyzed the effects of these treatments on locomotor activity. Main Outcome Measures The main outcome measures were frequencies of hops/darts and ear wiggling, lordosis quotient and intensity, and locomotor activity. Results Fluoxetine inhibited ear wiggling and hopping/darting, while bupropion stimulated hopping/darting. These treatments did not modify the lordosis quotient and its intensity. Yohimbine did not change any aspect of female sexual behavior. At the doses and treatments used, fluoxetine and bupropion did not alter locomotor activity or disturb the length of the estrous cycle; however, yohimbine inhibited locomotor activity. Conclusions The motivational components of female sexual behavior are more sensitive than the receptive components to the inhibitory actions of fluoxetine. Bupropion selectively stimulated hopping/darting, while yohimbine lacked an action on female sexual behavior.

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Section: Discussionsupporting

confidence: 88%

The Antidepressants Fluoxetine and Bupropion Differentially Affect Proceptive Behavior in the Naturally Cycling Female Rat

Ventura-Aquino

Fernández‐Guasti

2013

The Journal of Sexual Medicine

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“…Animals treated with yohimbine exhibit increased anxiety and fearful behavior, including conditioned place aversion, decreased social interaction, decreased exploration and potentiated startle (Davis et al, 1979;Pellow et al, 1985;Chopin et al, 1986;File, 1986;Bhattacharya et al, 1997). Yohimbine has been shown to increase or decrease locomotor activity depending on dose, behavioral paradigm, and route of administration (Zebrowska-Lupina and Kleinrok, 1973;Chopin et al, 1986;Verleye and Bernet, 1987;Bowes et al, 1992). The present data show not only that yohimbine increased measures of locomotor activity, but also that the response appeared to sensitize over time (Figure 2a).…”

Section: Discussionsupporting

confidence: 50%

Neural Activation Profile Elicited by Cues Associated with the Anxiogenic Drug Yohimbine Differs from That Observed for Reward-Paired Cues

Schroeder

Schiltz

Kelley

2002

Neuropsychopharmacol

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Cues associated with dangerous or rewarding outcomes can themselves elicit neural activation. Previous work in rats has shown that cues associated with morphine, cocaine, nicotine or palatable food can elicit enhanced expression of the immediate-early gene product Fos in discrete brain regions. Activation of the prefrontal cortex has been shown to be particularly prominent. Some studies have also shown prefrontal cortical activation following exposure to fear-inducing stimuli. To investigate the specificity of regional brain Fos activation, we treated rats with an anxiogenic drug, yohimbine (2 mg/kg, intraperitoneally (i.p.)), or water once per day for 10 consecutive days in a test environment distinct from their home cages. Yohimbine elicited a robust locomotor response that progressively sensitized over days. After a 4-day interval, rats were reintroduced to the paired environment, without drug treatment. Rats re-exposed to the environment where they had previously been treated with yohimbine showed conditioned increases in motor activity compared with controls. Fos expression was increased in several brain regions, including the basolateral amygdala, but was unchanged in prefrontal cortex, in contrast to what has been reported for rewarding drugs. These observations show a neural activation profile elicited by cues associated with the anxiogenic drug yohimbine and further support the hypothesis that prefrontal cortex has a specific role in reward expectancy.

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“…Consistent with the most recent finding from Lê and colleagues, ethanol consumption following the 2.5 mg/kg dose of yohimbine did not differ from vehicle in the present experiment. This dose of yohimbine significantly increases anxiety-like behavior [35], and a similar dose (2.0 mg/kg) decreases locomotor activity [67]. Thus, it is possible that stress-related suppression in activity or freezing could contribute to the effects of the high dose of yohimbine on ethanol self-administration, and could underlie the failure to complete the response requirement by four rats in the present experiment.…”

Section: Discussionmentioning

confidence: 91%

Alterations in ethanol seeking and self-administration following yohimbine in selectively bred alcohol-preferring (P) and high alcohol drinking (HAD-2) rats

Bertholomey

Verplaetse

Czachowski

2013

Behavioural Brain Research

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Evidence suggests that stress increases alcohol drinking and promotes relapse in humans. Animal models that assess related behaviors include the sipper tube ethanol self-administration and the stress-induced reinstatement paradigms. While selectively bred for the same high-ethanol-drinking behavior, alcohol-preferring P rats appear to show greater sensitivity to ethanol reinforcement than high-alcohol-drinking HAD rats. The present experiment tested the effects of the pharmacological stressor, yohimbine, on the motivation to seek and consume ethanol implementing a combined sipper tube/reinstatement model using male P and HAD-2 rats. Following training to self-administer ethanol using the sipper tube procedure, rats were tested for the effects of yohimbine (0.625-2.5 mg/kg) on ethanol drinking. Subsequently, rats were tested for the effects of 1.25 mg/kg yohimbine on reinstatement of ethanol seeking. Yohimbine (0.625 and 1.25 mg/kg) increased ethanol self-administration, and the latter dose also decreased latency to complete the response requirement. Yohimbine elicited reinstatement of ethanol seeking in both lines. HAD-2 rats drank more ethanol, but showed similar responding on the ethanol-associated lever compared to P rats. These findings extend both the reinstatement and sipper tube models and justify further exploration of this unique combined paradigm. Despite prior evidence suggesting that P rats are more motivated to seek and consume ethanol, differences in these behaviors between P and HAD-2 rats were not systematic in the present experiment. Further investigation may elucidate whether either selected line may be more sensitive than other selectively bred or outbred rats to stress-related changes in ethanol's reinforcing effects.

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Effects of yohimbine and idazoxan on motor behaviors in male rats

Cited by 12 publications

References 50 publications

The Antidepressants Fluoxetine and Bupropion Differentially Affect Proceptive Behavior in the Naturally Cycling Female Rat

The Antidepressants Fluoxetine and Bupropion Differentially Affect Proceptive Behavior in the Naturally Cycling Female Rat

Neural Activation Profile Elicited by Cues Associated with the Anxiogenic Drug Yohimbine Differs from That Observed for Reward-Paired Cues

Alterations in ethanol seeking and self-administration following yohimbine in selectively bred alcohol-preferring (P) and high alcohol drinking (HAD-2) rats

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