Effects of Xylitol and CPP-ACP Chewing Gum on Salivary Properties of Children with Molar Incisor Hypomineralization

Prathima, Gajula Shivashankarappa; Narmatha, M; Arumugam, Selvabalaji; Adimoulame, Sanguida; Ezhumalai, G

doi:10.5005/jp-journals-10005-1779

Cited by 5 publications

(7 citation statements)

References 10 publications

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“…The present findings indicated that both salivary flow rate and saliva pH were increased directly after the application of both placebo and CPP-ACP with a statistically significant difference between different time points. These findings were in agreement with of Prathima et al study (2021) which showed that maximum peak rise in salivary pH was observed immediately after spitting the CPP-ACP containing gums [17] de Oliveira PRA et al (2022) showed in their study that tooth remineralization of initial teeth demineralization gives better results in the presence of fluoride in conjunction with CPP-ACP. They also reported that placebotreated specimens incorporated fluoride from the saliva due to the high sensitivity of white spot lesions (demineralized enamel) to pH cycling.…”

Section: Discussionsupporting

confidence: 89%

“…However, a recent review recognized that there is a need to design further studies to make a reliable assessment between hyposalivation and dental caries in young patients [16]. Prathima et al study (2021) showed that maximum peak rise in salivary pH was observed immediately after spitting the CPP-ACP containing gums [17]. However, Ozdas et al (2015) showed that the increase buffering capacity of CPP-ACP was observed since the fourth week of application [18] A recent systematic review showed that there is an evidence regarding the remineralizing effect of CPP-ACP by studying the roughness of enamel.…”

Section: Introductionmentioning

confidence: 99%

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Remineralization of teeth with casein phosphopeptide-amorphous calcium phosphate: analysis of salivary pH and the rate of salivary flow

2023

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Aim To investigate the changes of salivary flow rate and salivary pH of Syrian children with mixed dentition following application of Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP). Methods This study is part of a double-blind randomized controlled clinical trial. It included 50 children aged 6–8 who were randomly divided into two treatment groups to receive either CPP-ACP GC Tooth Mousse™ (Group A) or placebo (Group B) with 25 participants per group. After the application of the product in the mouth for 3 min, saliva samples were collected four times (T0, T1, T2, and T3) to measure salivary pH and the rate of salivary flow. Results There was no significant difference between group A and B in the mean value of salivary flow rate (t = 1.08, P = 0.28, 0.57 ± 0.28 versus 0.56 ± 0.38 respectively) and salivary pH (t = 0.61, P = 0.54, 7.28 ± 0.44 versus 7.25 ± 0.36 respectively). However, there was a significant difference between different time points (T0, T1, T2, and T3) in the mean value of salivary flow rate (0.41 ± 0.30, 0.65 ± 0.36, 0.53 ± 0.28, and 0.56 ± 0.34 respectively) and salivary pH (6.99 ± 0.44, 7.46 ± 0.36, 7.36 ± 0.32, and 7.26 ± 0.32 respectively). Conclusion The application of the GC Tooth Mouse (CPP-ACP) was similar to placebo in increasing the salivary pH and salivary flow rate. Trial registration ISRCTN17509082, Registration date 22/11/2022.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Remineralization of teeth with casein phosphopeptide-amorphous calcium phosphate: analysis of salivary pH and the rate of salivary flow

2023

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“…According to research by Prathima et al, there is no significant difference between the two types of chewing gum with its ability to increase the flow rate, pH, and salivary buffer capacity. However, chewing gum with CPP-ACP content showed better results than gum with xylitol content in increased buffer action [25]. Another study by Padminee et al stated an increase in pH and salivary buffering ability after using gum with CPP-ACP content.…”

Section: Cpp-acp Vs Xylitol Chewing Gummentioning

confidence: 96%

“…Both chewing gum containing CPP-ACP and xylitol can increase the salivary flow rate and pH. This is because chewing gum for a long time will increase the stimulated saliva, which ultimately causes an increase in salivary pH [25,26]. According to research by Prathima et al, there is no significant difference between the two types of chewing gum with its ability to increase the flow rate, pH, and salivary buffer capacity.…”

Section: Cpp-acp Vs Xylitol Chewing Gummentioning

confidence: 99%

“…The material is proanthocyanidin, a polyphenol class compound that has a role as a tooth remineralization agent by inducing cross-linking formation [7,8]. The two ingredients are combined as chewing gum, which increases saliva's flow rate, which can trigger the remineralization of enamel and an increase in pH due to its buffer activity [9].…”

Section: Introductionmentioning

confidence: 99%

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Potential of CPP-ACP and cranberry proantho-cyanidin chewing gum for remineralization of perimylolysis in eating disorders patients

Indeswati Diyatri,

Sandira Farnan Indarta,

W Kusuma Annisaa Alfi Prasetya

et al. 2023

World J. Adv. Res. Rev.

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Background: Eating disorder (ED) is characterized by abnormalities in the pattern, amount, and nature of food eaten. Recent studies confirm the high prevalence of ED worldwide, which has increased significantly from 3.5% to 7.8% in the last 18 years. One of the common symptoms of ED sufferers is intentional vomiting, which can lower the pH of the oral cavity and induce perimylolysis. A new challenge is finding an innovation to alleviate perimylolysis in ED patients regarding behavior and dental treatment. Material and Methods: The literature review was carried out in PUBMED, ResearchGate, and ScienceDirect with the keywords: CPP-ACP, proanthocyanidin, chewing gum, eating disorder. Conclusions: Chewing gum containing CPP-ACP and proanthocyanidins from cranberries has been shown to have remineralization potential to help relieve perimylolysis in ED patients from a behavioral and dental perspective.

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Efficacy of CPP-ACP GC Tooth Mousse in remineralization of teeth of Syrian orphan Children- results of a double -blind, randomized controlled clinical trial

Alkarad

Alkhouli

Dashash

2023

Preprint

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Objectives A double-blind randomized controlled clinical trial was undertaken to evaluate the efficacy of Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) in the remineralization of teeth of Syrian children aged 6-8 years enrolled in orphanage of the city of Damascus. Materials and Methods The study sample included 50 children randomly divided into two treatment groups to receive either CPP-ACP GC Tooth Mousse™ (Group A) or placebo (Group B) with 25 participants per group. After the application of the product in the mouth for 3 minutes, saliva samples were collected four time (T0, T1, T2, and T3) to measure the pH of saliva and the rate of salivary flow. Results There was no significant difference between group A and B in the mean value of salivary flow rate and salivary pH. However, there was significant difference between different time points in the mean value of salivary pH and salivary flow rate. Conclusion The GC Tooth Mouse (CPP-ACP) is not superior to placebo mousse at tooth remineralization according to salivary pH measure and the rate of salivary flow. Further studies are still essential to assertion findings. Trial registration: ISRCTN17509082, Registration date 22/11/2022

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Effects of Xylitol and CPP-ACP Chewing Gum on Salivary Properties of Children with Molar Incisor Hypomineralization

Cited by 5 publications

References 10 publications

Remineralization of teeth with casein phosphopeptide-amorphous calcium phosphate: analysis of salivary pH and the rate of salivary flow

Remineralization of teeth with casein phosphopeptide-amorphous calcium phosphate: analysis of salivary pH and the rate of salivary flow

Potential of CPP-ACP and cranberry proantho-cyanidin chewing gum for remineralization of perimylolysis in eating disorders patients

Efficacy of CPP-ACP GC Tooth Mousse in remineralization of teeth of Syrian orphan Children- results of a double -blind, randomized controlled clinical trial

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