Effects of xipayi mouth rinse combined with minocycline on localized aggressive periodontitis’ therapeutic effect and the levels of CRP, TNF-α, IL-6 in serum

Abstract

Background: Localized aggressive periodontitis is rare periodontitis in clinical practice, which often occurs in young adults under 35 years old, seriously affecting patients' quality of life. As a tetracycline antibacterial drug, minocycline is also considered an essential choice to treat periodontal disease. However, few reports focused on the effect of xipayi mouth rinse combined with minocycline on periodontal pathogens. The goal of this study was to investigate the clinical effect of xipayi mouth rinse combined with minocycline in the treatment of localized aggressive periodontitis and its effect on the levels of CRP, TNF-α, and IL-6.Methods: Ninety-six patients with limited aggressive periodontitis were selected and randomly divided into two groups. Forty-eight patients in the control group were treated with xipayi mouth rinse after primary periodontal treatment. Then, 48 patients in the experimental group were treated with xipayi mouth rinse combined with minocycline after primary periodontal treatment. The periodontal probe was applied to detect periodontal plaque index (PLI), periodontal pocket depth (PD), sulcus bleeding index (SBI), gingival index (GL), and clinical attachment loss (CAL) before and after treatment in both groups of patients. ELISA was used for detecting the expression levels of CRP, TNF-α, and IL-6 in the serum of patients in two groups before and after treatment. We compared the recurrence rates of the two groups after a 1-year follow-up.Results: Compared with the control group, the PLI, PD, SBI, GL, CAL, and total masticatory efficiency of the experimental group were significantly better than those of the control group. The levels of inflammatory factors CRP, TNF-α, and IL-6 were significantly declined, and the total effective rate of treatment was significantly elevated. After follow-up, it was found there was no noticeable difference in the recurrence rate between the two groups.Conclusions: Xipayi mouth rinse, combined with minocycline in the treatment of localized aggressive periodontitis, can significantly improve the periodontal gingival condition and reduce the level of inflammatory factors. Also, the efficacy of the treatment was significant. This experiment has provided ideas for improving the clinical treatment of patients with localized aggressive periodontitis.

Clinical Effect and Aesthetic Observation of All-on-4 Immediate Loading Implant Denture in Severe Periodontitis

“…As a hormone secreted by adipose tissue, LEP can reflect the level of inflammation in the body and is a key factor leading to host infection and the production of proinflammatory factors. At the same time, periodontitis is mainly caused by G-anaerobe infection, and its endotoxin lipopolysaccharide can stimulate the secretion of inflammatory factors such as TNF- α , CRP, and IL-6, which increase the inflammation level of periodontal tissues [ 20 , 21 ]. All-on-4 immediate loading implant technology can effectively improve the oral environment of patients with severe periodontitis and reduce the level of inflammation.…”

Mussel-Inspired Caries Management Strategy: Constructing a Tribioactive Tooth Surface with Remineralization, Antibiofilm, and Anti-inflammation Activity

“…The above results show that TGE had an anti-inflammatory effect. Studies have shown the anti-inflammation mechanism of TGE is that the formation of hydrogen peroxide, superoxide anion O 2 and hydroxyl radicals could be inhibited by polyphenols in TGE, alleviating inflammatory reactions such as edema and capillary exudation, maintaining a good oral state …”

“…Studies have shown the anti-inflammation mechanism of TGE is that the formation of hydrogen peroxide, superoxide anion O 2 and hydroxyl radicals could be inhibited by polyphenols in TGE, alleviating inflammatory reactions such as edema and capillary exudation, maintaining a good oral state. 54 Biocompatibility. To evaluate the biocompatibility of TGE, the hemocompatibility and cytotoxicity were tested.…”

Epidemiology of periodontal disease in adolescents in mainland China, 1983–2020: a systematic review and meta-analysis

“…The results showed that the prevalence rate of gingivitis among adolescents estimated by BOP(+) was 48.8%, so the periodontal situation of adolescents should not be ignored, which was reported to be 20% in South Australia (54), 34.9% in Italy (55), and 14% in Japan (11). These differences in the results of gingivitis prevalence may be related to better oral hygiene and related consciousness in developed countries (56,57).…”