Effects of xenon on ischemic spinal cord injury in rabbits: a comparison with propofol

Abstract

The results indicated that 70% of xenon has no additional neuroprotective effects on ischemic spinal cord injury in rabbits compared with propofol.

Post‐conditioning by xenon reduces ischaemia‐reperfusion injury of the spinal cord in rats

“…Yamamoto et al. compared the effect of xenon and propofol pre‐conditioning on spinal cord injury following spinal cord ischaemia in a rabbit model and concluded that 70% (v/v) xenon has no additional neuroprotective effect on ischaemic spinal cord injury in rabbits . At present, no literature on the possible neuroprotective effect of xenon post‐conditioning on ischaemia‐reperfusion injury of the spinal cord is available.…”

“…Recently, both in vivo and in vitro studies confirmed that xenon has a neuroprotective effect in the brain following ischaemic and hypoxic injury . To date, most studies on xenon have focused on the effect of pre‐conditioning, and few studies have investigated the effect of xenon on neurons of the spinal cord. In 2010, Sinha and Cheung reported that apoptosis played an important role in secondary injury of the spinal cord following ischaemia.…”

Noble gases as cardioprotectants – translatability and mechanism

“…By far the most information on organ protection by noble gases comes from studies using xenon as an inhalational agent. Experimental studies have clearly shown that xenon protects the brain (Limatola et al ., ), spinal cord (Yamamoto et al ., ; Yang et al ., ), kidney (Ma et al ., ), heart (Weber et al ., 2005a,b) and vascular endothelium (Weber et al ., ) from ischaemia reperfusion injury.…”

Ischemia-Reperfusion Injury and Volatile Anesthetics

“…Halothane and enflurane are no longer investigated for this purpose due to decreased usage of these agents. However, some studies suggested that there is no protection [29, 57, 58], moreover harmful [59] effects of volatile anesthetics.…”