Effects of X-ray Irradiation on Viscosity of Synovial Fluid

Ragan, Charles; Donlan, Charlotte P.; Coss, James A.; Grubin, Audrey F.

doi:10.3181/00379727-66-16023

Cited by 21 publications

(6 citation statements)

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“…The influence of irradiation on the degradation of HA, − especially in connection with eye pathologies, , has long been a main focus of HA research. UV irradiation reduces the viscosity of HA solutions. , The intervention of reactive oxygen radicals and singlet oxygen in connection with UV irradiation, led to destruction of the interglycosidic bonds in addition to decarboxylation.…”

Section: 3 Degradation By Free Radicalsmentioning

confidence: 99%

Hyaluronan: Preparation, Structure, Properties, and Applications

Lapčík

Smedt²,

Demeester³

et al. 1998

Chem. Rev.

661

313

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under Prof. S. Claesson. Holding 24 industrial patents and author of more than 120 publications, he has lectured at several European universities. His current interest is in the photochemistry and physical chemistry of polymers. He is a member of the Czech Chemical Society. Stefaan De Smedt was born in Geraardsbergen, Belgium, in 1967. He studied pharmacy at the University of Ghent, Belgium, and received his M.S. degree in pharmaceutical sciences in 1990. As a scholar of the Belgian Institute for the Encouragement of Scientific Research in Industry and Agriculture, he enrolled in a Ph.D. program at the University of Ghent, under the direction of Prof. J. Demeester. He studied rheology at the Catholic University of Leuven. He received the Scott Blair Biorheology Award in 1993−1995 for his work on the structural characterization of hyaluronan solutions. To study diffusion phenomena in polymer solutions, he collaborated with Prof. Y. Engelborghs at the Laboratory of Biomolecular Dynamics of the Catholic University of Leuven. In 1995, he joined the pharmaceutical development group of Janssen Research Foundation. Since 1997 he has been a postdoctoral fellow of F.W.O.-Vlaanderen at the Laboratory of General Biochemistry and Physical Pharmacy of the University of Ghent. He is a member of the Controlled Release Society, the European Federation for Pharmaceutical Sciences, the Belgian Society for Pharmaceutical Sciences, the European Society of Rheology, the Belgian Biophysical Society, and the Polymer Networks Group. He is a consultant to the Journal of Controlled Release and to Pharmaceutical Research. His current research interests include the mobility and interactions of macromolecular drugs in pharmaceutical polymer matrixes and biological polymer systems.

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Section: 3 Degradation By Free Radicalsmentioning

confidence: 99%

Hyaluronan: Preparation, Structure, Properties, and Applications

Lapčík

Smedt²,

Demeester³

et al. 1998

Chem. Rev.

661

313

View full text Add to dashboard Cite

show abstract

“…Others have described similar depolymerization by x-ray irradiation (106)(107)(108), ultraviolet light (709, 770), visible light (777), ultrasonic vibrations (112,113), electrons (109), and ferric, ferrous, and cupric ions (114). e. Nonenzymic Degradation of Biological Interest.…”

mentioning

confidence: 90%

Metabolism of Polysaccharides Containing Glucuronic Acid

Silbert¹

1966

Glucuronic Acid Free and Combined

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“…When a polysaccharide is irradiated in aqueous solution the viscosity decreases (217,347,348,416,497,504,524). For starch, agar-agar, and gum arabic the formation of reducing substances has been demonstrated and the pH has been shown to decrease (347,348).…”

Section: Aqueous Solutionsmentioning

confidence: 99%

“…For starch, agar-agar, and gum arabic the formation of reducing substances has been demonstrated and the pH has been shown to decrease (347,348). Hyaluronic acid exhibits a viscosity after-effect, but the decrease in viscosity after irradiation is less than that during irradiation (416,497,524). Very little is known about the mode of action, except that Fenton's reagent, like radiation, produces a viscosity decrease on alginic acid (217), thus implying that hydroxyl radicals could be the effective agents.…”

Section: Aqueous Solutionsmentioning

confidence: 99%