Effects of X-irradiation on the proliferation of cells in peripheral nerve during allerian degeneration in the rat

Jb, Cavanagh

doi:10.1259/0007-1285-41-484-275

Cited by 75 publications

(17 citation statements)

References 9 publications

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“…causing neurological dysfunction (1,21,22) and any treatment that could relieve these symptoms is highly desirable. Radiation therapy can further cause hearing loss by inducing local damage to mature nerve tissue, which is partly attributable to microvascular injury (23,24). Whereas the role of VEGF on tumor angiogenesis and progression has been well characterized, the role of anti-VEGF treatment on tumor-related neuropathy remains largely unknown.…”

Section: Fig 2 Anti-vegf Treatment Decreases Muscle Atrophy (A) Rementioning

confidence: 99%

Anti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma model

Gao

Zhao

Stemmer‐Rachamimov

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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Hearing loss is the main limitation of radiation therapy for vestibular schwannoma (VS), and identifying treatment options that minimize hearing loss are urgently needed. Treatment with bevacizumab is associated with tumor control and hearing improvement in neurofibromatosis type 2 (NF2) patients; however, its effect is not durable and its mechanism of action on nerve function is unknown. We modeled the effect anti-VEGF therapy on neurological function in the sciatic nerve model and found that it improves neurological function by alleviating tumor edema, which may further improve results by decreasing muscle atrophy and increasing nerve regeneration. Using a cranial window model, we showed that anti-VEGF treatment may achieve these effects via normalizing the tumor vasculature, improving vessel perfusion, and delivery of oxygenation. It is known that oxygen is a potent radiosensitizer; therefore, we further demonstrated that combining anti-VEGF with radiation therapy can achieve a better tumor control and help lower the radiation dose and, thus, minimize radiation-related neurological toxicity. Our results provide compelling rationale for testing combined therapy in human VS.NF2 schwannoma model | anti-VEGF | neurological function | radiation

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Section: Fig 2 Anti-vegf Treatment Decreases Muscle Atrophy (A) Rementioning

confidence: 99%

Anti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma model

Gao

Zhao

Stemmer‐Rachamimov

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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“…These late sequelae include spinal cord myelopathy, necroses with fatal hemorrhage and cranial nerve palsies [3], Radiation-induced nerve palsies usually become ap parent after a latent period of 1-5 years following therapy [4], Many studies have reported an inverse relation be tween the dose and the latent period [2], The exact mecha nism accounting for radiation-induced peripheral nerve damage is unclear [4], Some authors suggest a direct nerve damage as the possible mechanism. This conclusion is based on short follow-up in experimental studies [9]. Additionally long latent periods observed in clinical situa tions do not support this theory.…”

Section: Discussionmentioning

confidence: 78%

Bilateral Vocal Cord Paralysis following Radiation Therapy for Nasopharyngeal Carcinoma

Chaudhry

Akhtar²

1995

ORL

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Cranial nerve palsies are uncommon late sequelae of radiation therapy. We present a rare case of bilateral vocal cord paralysis secondary to radiation-induced recurrent laryngeal nerve paralysis. The exact mechanism accounting for radiation-induced nerve damage is unknown. The complication may occur years following radiation therapy thus making a causal relationship difficult. As there is no treatment available, the therapy should aim to improve the functional impairment produced by the nerve involved.

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“…This phenomenon was also reported by Delanian et al, who described radiation‐induced peripheral neuropathy as a chronic handicap, usually appearing several years after radiotherapy. A possible mechanism for radiation‐induced peripheral neuropathy may be initial microvascular injury, with subsequent radiation‐induced fibrosis (RIF) . Marked fibrosis surrounding the nerve trunk with fibrous infiltration and replacement of nerve fibers was noted in the autopsy results of 2 patients with breast cancer with brachial plexopathy after postoperative radiotherapy .…”

Section: Discussionmentioning

confidence: 99%

Laryngeal electromyography findings of vocal fold immobility in patients after radiotherapy for nasopharyngeal carcinoma

2013

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Effects of X-irradiation on the proliferation of cells in peripheral nerve during allerian degeneration in the rat

Cited by 75 publications

References 9 publications

Anti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma model

Anti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma model

Bilateral Vocal Cord Paralysis following Radiation Therapy for Nasopharyngeal Carcinoma

Laryngeal electromyography findings of vocal fold immobility in patients after radiotherapy for nasopharyngeal carcinoma

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