Effects of word frequency on recall memory following lorazepam, alcohol, and lorazepam alcohol interaction in healthy volunteers

Soo-Ampon, Surin; Wongwitdecha, Noppamars; Plasen, Surin; Hindmarch, Ian; Boyle, Julia

doi:10.1007/s00213-004-1888-5

Cited by 15 publications

(9 citation statements)

References 41 publications

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“…The test has been shown to be sensitive in detecting the effects of psychoactive compounds. 24 line analog rating scales. The subjects marked a series of 100-unit line analog scales assessing the following components: dizzy, clumsy, anxious, relaxed, tired, drowsy, alert, energetic, sad, and depressed.…”

Section: Methods Subjectsmentioning

confidence: 99%

Acute Alertness-Promoting Effects of a Novel Histamine Subtype-3 Receptor Inverse Agonist in Healthy Sleep-Deprived Male Volunteers

Iannone

Palcza

Renger

et al. 2010

Clin Pharmacol Ther

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The alertness-promoting effect of MK-0249 (10 or 50 mg), a histamine subtype-3 receptor (HRH3) inverse agonist (IA), was evaluated in the stimulant reference sleep deprivation model (SRSDM) using a double-blind, double-dummy, placebo- and modafinil- (200 mg) controlled, four-period crossover design in 24 healthy young men. The two primary hypotheses were related to sleep latency (first appearance of one epoch of stage 2, 3, or 4 or REM sleep, as detected using polysomnography (PSG)) at 8:00 AM on day 2. Statistically significant increases in sleep latency were observed in association with the use of modafinil 200 mg (9.07 min; P < 0.0001), MK-0249 50 mg (5.17 min; P = 0.008), and MK-0249 10 mg (5.45 min; P = 0.005) at the maintenance of wakefulness test (MWT) at 8:00 AM. Sleep latency was higher when averaged over all MWT time points (P < 0.0001 for modafinil and for both doses of MK-0249). The alertness-promoting effect with the use of MK-0249 in the SRSDM suggests that HRH3 IAs may be effective in disorders involving excessive somnolence.

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Section: Methods Subjectsmentioning

confidence: 99%

Acute Alertness-Promoting Effects of a Novel Histamine Subtype-3 Receptor Inverse Agonist in Healthy Sleep-Deprived Male Volunteers

Iannone

Palcza

Renger

et al. 2010

Clin Pharmacol Ther

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“…Free recall of words from word tests is a frequently used assessment of memory and amnesia. 18,19 A research associate recorded the BIS and ETCO 2 values at the time the word was read, and recorded whether the patient was able to repeat the word aloud. The patient was then sedated with propofol, 1.0-mg/kg bolus followed by a 0.5-mg/kg bolus every 3 minutes as needed for sedation.…”

Section: Methodsmentioning

confidence: 99%

“…We recognize that moderately undemanding tests of memory function (word recall) were used in this study. A similar method of memory assessment has been used in multiple studies 18,19,21,22 ; however, the standardized set of words we used was created by us, simply because there is a lack of published word sets specifically designed to investigate short-term memory. It is possible that these words were not devised appropriately and that some memory functions may be correlated with a more potent stimulus.…”

Section: Limitationsmentioning

confidence: 99%

Assessment of the Onset and Persistence of Amnesia during Procedural Sedation with Propofol

Miner¹,

Bachman

Kosman

et al. 2005

Academic Emergency Medicine

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“…Psychometric assessments have shown that a number of cognitive functions are adversely affected by increased sedation including information processing, memory and attention [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Benzodiazepine‐induced reduction in activity mirrors decrements in cognitive and psychomotor performance

Dawson

Boyle

Stanley

et al. 2008

Human Psychopharmacology

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What this paper addsWhat is already knownThe evaluation of psychotropic drug effects has been conducted utilising psychometric test batteries to assess changes in daytime cognition and psychomotor functioning and PSG to assess changes in sleep. Actigraphy is widely accepted as a non-invasive tool for assessing sleep-wake patterns in different groups. However, there is limited data to show that actigraphy can reliably measure the daytime and night-time characteristics of a CNS drug. What this study adds -This study provides further evidence that actigraphy is sensitive not only to the sedating effects of a hypnotic drug but also to the hangover effects of the drug the following morning. It confirms that the actiwatch is able to detect the effects of a hypnotic on actigraphically measured sleep. Further evidence that actigraphy can provide a reliable and sensitive indication of the time course of action of psychoactive drugs. Lorazepam-induced reduction in activity 3 ABSTRACTAim: To assess whether actigraphy is sensitive to lorazepam-induced changes in cognitive and psychomotor performance by measuring activity levels following placebo and lorazepam (LZP) dosing.Methods: Healthy volunteers were randomised to a double-blind, placebocontrolled, crossover trial. Activity was recorded by actigraphy throughout each test period and pooled into 30 min bins for analysis. Following LZP dosing (2.5 mg at 18.00 h) psychomotor and cognitive tests were conducted at regular intervals.Results: Activity levels were significantly reduced between the psychometric tests (P < 0.02) at 2, 3 and 5 h post dose and during the psychometric tests (P < 0.02) at 2.5 and 4.5 h post dose. Subjects only felt sedated (P < 0.01) at 4.5 h post dose. Activity levels were also significantly reduced (P < 0.05) during sleep (23:00-07:00 h), and the following morning, activity levels remaining suppressed (P < 0.02) at 13.5 and 14 h post dose. Cognitive and psychomotor performance reflected changes in activity levels with significant impairment (P < 0.05) at 2.5, 3.5, 4.5 and 14.5 h post dose.Conclusion: This study showed that actigraphic activity levels were significantly reduced following LZP dosing. These changes were mirrored by impairment of cognitive and psychomotor performance. Actigraphy is therefore sensitive to the sedating effect of LZP and appears able to detect changes in sleep behaviour (hypnotic efficacy) and residual effects the following morning. Actigraphy may thus be a useful tool in assessing the psychopharmacology of CNS medication. Lorazepam-induced reduction in activity4

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Effects of word frequency on recall memory following lorazepam, alcohol, and lorazepam alcohol interaction in healthy volunteers

Cited by 15 publications

References 41 publications

Acute Alertness-Promoting Effects of a Novel Histamine Subtype-3 Receptor Inverse Agonist in Healthy Sleep-Deprived Male Volunteers

Acute Alertness-Promoting Effects of a Novel Histamine Subtype-3 Receptor Inverse Agonist in Healthy Sleep-Deprived Male Volunteers

Assessment of the Onset and Persistence of Amnesia during Procedural Sedation with Propofol

Benzodiazepine‐induced reduction in activity mirrors decrements in cognitive and psychomotor performance

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