Effects of withdrawal from long-term diphenylhydantoin treatment on audiogenic and maximal electroshock-induced seizures in rats

Abstract

Rats withdrawal from long-term diphenylhydantoin treatment (DPH) were tested for their sensibility t o convulsant stimuli. Animals were more sensitive t o convulsions elicited by maximal electroshock and sound, respectively, at 48 and 72 h after drug removal. These results suggest that long-term D P H treatment might develop a central nervous system supersensitivity state.