Effects of Whole Body Vibration Exercise associated with Quadriceps Resistance Exercise on functioning and quality of life in patients with knee osteoarthritis: a randomized controlled trial

Wang, Pu; Yang, Lin; Liu, Chuan; Wei, Xiaofei; Yang, Xiaoxia; Zhou, Yujing; Jiang, Hua; Zheng, Lei; Reinhardt, Jan D.; He, Chengqi

doi:10.1177/0269215515607970

Cited by 42 publications

(65 citation statements)

References 33 publications

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“…Other studies investigating the effect of exercise on CTX‐II level in patients with knee OA show conflicting results. Wang et al found that 24 weeks of quadriceps strengthening exercises conducted 40 minutes 5 days per week reduced CTX‐II level. Further reduction was shown when adding 30 minutes of whole‐body vibration exercise .…”

Section: Discussionmentioning

confidence: 99%

“…Wang et al found that 24 weeks of quadriceps strengthening exercises conducted 40 minutes 5 days per week reduced CTX‐II level. Further reduction was shown when adding 30 minutes of whole‐body vibration exercise . Likewise, Azukizawa et al showed reduced CTX‐II level at 24 weeks after a well‐rounded exercise program with one weekly supervised exercise class the first 12 weeks followed by a 12‐week period of encouraged self‐training.…”

Section: Discussionmentioning

confidence: 99%

“…In agreement with our findings, Petersen et al and Andersson et al found no change in COMP level after 12 weeks of moderate to heavy progressive quadriceps strength training 3 times weekly, respectively 24 weeks of high‐intensity weight‐bearing exercise one hour twice weekly in patients with knee OA. In contrast, COMP level was found to be decreased after 24 weeks of quadriceps resistance training or increased in patients with pre‐radiological knee OA and radiological knee OA after the 24‐week well‐rounded exercise program and in a group of overweight and obese patients with knee OA following one hour of aerobic and resistance training three times weekly for 18 months when compared to a control group . Andersson et al confirmed an acute rise in COMP after one hour of exercise, but also that the increased COMP level was normalized after 30 minutes of rest underlining the importance of controlling for physical activity before sampling.…”

Section: Discussionmentioning

confidence: 99%

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The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

et al. 2019

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Exercise is recommended as first‐line treatment to reduce pain and improve physical function in patients with hip osteoarthritis, but the mechanism behind the effect remains unknown. Blood and urine were collected at baseline and after 4 months of exercise from 60+‐year‐old persons (n = 39) with hip osteoarthritis included in a randomized controlled trial comparing the effects of strength training (ST), Nordic Walking (NW), and unsupervised home‐based exercise (control). We measured biomarkers of bone (N‐terminal propeptide of type I collagen, C‐telopeptide of type I collagen, sclerostin, receptor activator of nuclear factor kappa‐B ligand, and osteoprotegerin) and cartilage (C‐telopeptide of type II collagen (CTX‐II), cartilage oligomeric matrix protein, and N‐terminal propeptide of type III collagen). Sclerostin levels decreased independent of the type of training. There was significant interaction between type of training and change in CTX‐II level. When combining the supervised groups (NW and ST), both CTX‐II and sclerostin level were decreased in the supervised training group, while CTX‐II and sclerostin were unchanged in the control group. In conclusion, CTX‐II and sclerostin level were reduced by 4 months of supervised training, suggesting that certain types of exercise affect cartilage and bone, potentially contributing to beneficial effects of exercise in patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

et al. 2019

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“…WBV training is a safe method for rehabilitation of knee osteoarthritis (64,70) as no adverse effects are reported by the patients (70). Compared to regular strength training, WBV causes lower loads on the affected joint due to low joint dynamics during exercise (64).…”

Section: Orthopedicsmentioning

confidence: 99%

“…An 8-week WBV-exercise program on a balance board with a built-in vibrating device resulted in knee proprioception improvement as assessed based on threshold for detection of passive movement (64). Long-term vibration training (24 weeks, 5 days/week) in combination with quadriceps resistance exercise has benefits on functions and quality of life in patients with knee osteoarthritis (70). According to Park et al (48), there was no significant difference between the experimental group (WBV and home-based exercise) and the control group (home-based exercise) on quadriceps muscle strength after 8 weeks of intervention.…”

Section: Orthopedicsmentioning

confidence: 99%

The application of whole-body vibration in physiotherapy – A narrative review

et al. 2016

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Whole-body vibration (WBV) training is a very popular kind of practice in sport, fitness and physiotherapy. This work reviews the current knowledge regarding the use and effectiveness of WBV in the physiotherapy. The discrepancies between different authors' results are probably due to divergence in WBV training protocols. The paperwork clearly showed that despite its ultimate effects, exercises on a vibration platform are safe, feasible, and well tolerated by patients with different disorders. This narrative review should help physiotherapists verify therapy programs regarding patients' exposure to WBV.

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Impact of Exercise Therapy on Molecular Biomarkers Related to Cartilage and Inflammation in Individuals at Risk of, or With Established, Knee Osteoarthritis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Struglics

Larsson

Steultjens

et al. 2019

Arthritis Care & Research

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Objective. To investigate the impact of exercise therapy on molecular biomarkers related to cartilage and inflammation in individuals at risk of, or with established, knee osteoarthritis by conducting a systematic review of randomized controlled trials (RCTs).Methods. We conducted a literature search up to September 2017 in 5 major databases with no restriction on publication year or language. Data were extracted from the first available follow-up time point, and we performed a narrative synthesis for the effect of exercise therapy on molecular biomarkers related to cartilage and inflammation. A subset of studies reporting sufficient data was combined in a meta-analysis, using an adjusted random-effects model.Results. Twelve RCTs involving 57 study comparisons at 4 to 24 weeks following an exercise-therapy intervention were included. Exercise therapy decreased molecular biomarkers in 17 study comparisons (30%), had no effect in 36 (63%), and increased molecular biomarkers in 4 study comparisons (7%). Meta-analyses of 9 biomarkers showed that exercise therapy was associated with nonsignificant reductions of the C-reactive protein level, Cterminal crosslinking telopeptide of type II collagen, tumor necrosis factor (TNF), soluble TNF receptors 1 and 2, C2C neoepitope of type II collagen, and cartilage oligomeric matrix protein, compared to nonexercising control groups, and exercise therapy had no effect on interleukin-6 and soluble interleukin-6 receptor.Conclusion. Exercise therapy is not harmful, because it does not increase the concentration of molecular biomarkers related to cartilage turnover and inflammation, implicated in osteoarthritis progression. The overall quality of evidence was downgraded to low because of the limited number of RCTs available.

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Effects of Whole Body Vibration Exercise associated with Quadriceps Resistance Exercise on functioning and quality of life in patients with knee osteoarthritis: a randomized controlled trial

Abstract: Over a six months period, WBVE in combination with QRE was superior to QRE in most outcomes.

Cited by 42 publications

References 33 publications

The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

The application of whole-body vibration in physiotherapy – A narrative review

Impact of Exercise Therapy on Molecular Biomarkers Related to Cartilage and Inflammation in Individuals at Risk of, or With Established, Knee Osteoarthritis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

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