Effects of whole-body cryotherapy on a total antioxidative status and activities of antioxidative enzymes in blood of depressive multiple sclerosis patients

Multiple sclerosis (MS) is an autoimmune disease characterised by lymphocytic infiltration of the central nervous system and subsequent destruction of myelin and axons. On the background of a genetic predisposition to autoimmunity, environmental triggers are assumed to initiate the disease. The majority of MS research has focused on the pathological involvement of lymphocytes and other immune cells, yet a paucity of attention has been given to erythrocytes, which may play an important role in MS pathology. The following review briefly summarises how erythrocytes may contribute to MS pathology through impaired antioxidant capacity and altered haemorheological features. The effect of disease-modifying therapies on erythrocytes is also reviewed. It may be important to further investigate erythrocytes in MS, as this could broaden the understanding of the pathological mechanisms of the disease, as well as potentially lead to the discovery of novel and innovative targets for future therapies.

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“…Whole-body cryotherapy consists of exposure to extremely low temperatures, during which less oxygen is required, reducing oxidative stress. 24 …”

Section: Impaired Erythrocyte Antioxidant Capacity In Msmentioning

confidence: 99%

Erythrocytes in multiple sclerosis – forgotten contributors to the pathophysiology?

Groen

Maltby

Sanders

et al. 2016

Multiple Sclerosis Journal - Experimental, Translational and Cl

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“…About half of RRMS patients after 10–20 years of disease lasting accumulate irreversible neurological deficits [67, 70]. This type of MS is known as secondary progressive (SPMS) that is dominated by neurodegeneration processes and progression of clinical symptoms [71]. The next 20% of MS patients with progressive symptoms from the onset have primary-progressive (PPMS) type.…”

Section: Multiple Sclerosismentioning

confidence: 99%

Isoprostanes and Neuroprostanes as Biomarkers of Oxidative Stress in Neurodegenerative Diseases

Miller

Morel

Saso

et al. 2014

Oxidative Medicine and Cellular Longevity

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115

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Accumulating data shows that oxidative stress plays a crucial role in neurodegenerative disorders. The literature data indicate that in vivo or postmortem cerebrospinal fluid and brain tissue levels of F2-isoprostanes (F2-IsoPs) especially F4-neuroprotanes (F4-NPs) are significantly increased in some neurodegenerative diseases: multiple sclerosis, Alzheimer's disease, Huntington's disease, and Creutzfeldt-Jakob disease. Central nervous system is the most metabolically active organ of the body characterized by high requirement for oxygen and relatively low antioxidative activity, what makes neurons and glia highly susceptible to destruction by reactive oxygen/nitrogen species and neurodegeneration. The discovery of F2-IsoPs and F4-NPs as markers of lipid peroxidation caused by the free radicals has opened up new areas of investigation regarding the role of oxidative stress in the pathogenesis of human neurodegenerative diseases. This review focuses on the relationship between F2-IsoPs and F4-NPs as biomarkers of oxidative stress and neurodegenerative diseases. We summarize the knowledge of these novel biomarkers of oxidative stress and the advantages of monitoring their formation to better define the involvement of oxidative stress in neurological diseases.

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“…A single molecule of N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK), the first melatonin metabolite, can neutralize up to 10 ROS/NOS (reactive oxygen/nitrogen species) by the 'free radical scavenging cascade' 94 . Significant increase of total anti-oxidative status (TAS) level in plasma of multiple sclerosis (MS) patients has been observed with melatonin supplementation 95 .…”

Section: Resultsmentioning

confidence: 99%

Untitled

2013

IJPSR

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ABSTRACT:Introduction: Melatonin is a neuro-hormone secreted from the pineal gland and involved in various regulatory activities in body. Ever-increasing use of melatonin supplements and enlarging research evidences make the authors undertook the review to arrive at a qualitative conclusion whether melatonin supplements can act as potential treatment options or not. Methodology: A comprehensive search was undertaken in different electronic databases using various search terms. A total of 225 studies were identified including clinical research studies and basic experiments. Data were extracted individually from the studies and compiled in the end. Results: Melatonin has been used successfully in chronic insomnia and as an anti-oxidant in cancer and other age-related neuro-degenerative disorders, especially Alzheimer's disease and Autistic disorders. Its evidences of use in other conditions remained insufficient and inconclusive. Conclusion: Melatonin therapy may be considered as efficacious and safe in insomnia and as an anti-oxidant; however, other roles needs to be evaluated in further studies.

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Effects of whole-body cryotherapy on a total antioxidative status and activities of antioxidative enzymes in blood of depressive multiple sclerosis patients

Abstract: Our results indicate that WBCT suppresses OS in MS patients, especially in depressive patients.

Cited by 53 publications

References 15 publications

Erythrocytes in multiple sclerosis – forgotten contributors to the pathophysiology?

Erythrocytes in multiple sclerosis – forgotten contributors to the pathophysiology?

Isoprostanes and Neuroprostanes as Biomarkers of Oxidative Stress in Neurodegenerative Diseases

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