Effects of whey protein nutritional supplement on muscle function among community-dwelling frail older people: A multicenter study in China

Kang, Lin; Gao, Ying; Liu, Xiaohong; Liang, Yinghui; Chen, Yiwen; Liang, Yanhong; Zhang, Lu; Chen, Wei; Pang, Haiyu; Peng, Li Ning

doi:10.1016/j.archger.2019.03.012

Cited by 38 publications

(46 citation statements)

References 15 publications

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“…Randomized controlled trials have predominantly used varying doses of whey protein and in several instances combined it with exercise. Kang [17] provided 32.4 g of whey protein vs. a control diet for 12 weeks along with a 30 min home-based resistance exercise program taught by a professional physical therapist to 115 male and female subjects over the age of 60 with some markers of frailty. At the end of the 12 weeks, the whey supplemented group showed a significant increase in grip strength, gait speed, and time to complete chair stands.…”

Section: Proteinmentioning

confidence: 99%

Nutrition and Sarcopenia—What Do We Know?

2020

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Muscle health is important for the functionality and independence of older adults, and certain nutrients as well as dietary patterns have been shown to offer protective effects against declines in strength and function associated with aging. In this paper, micronutrients, macronutrients, and food groups have been reviewed, along with their studied effects on the prevalence and incidence of sarcopenia, as well as their ability to preserve muscle mass and optimize physical performance. Randomized controlled trials appear to suggest a critical role for dietary intake of protein in preventing sarcopenia and muscle loss, although the optimal dose and type of protein is unknown. There are some promising data regarding the role of vitamin D and sarcopenia, but it is unclear whether the dose, frequency of dose, or length of treatment impacts the efficacy of vitamin D on improving muscle mass or function. Selenium, magnesium, and omega 3 fatty acids have been studied as supplements in clinical trials and in the diet, and they appear to demonstrate a potential association with physical activity and muscle performance in older individuals. Following the Mediterranean diet and higher consumption of fruits and vegetables have been associated with improved physical performance and protection against muscle wasting, sarcopenia, and frailty.

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Section: Proteinmentioning

confidence: 99%

Nutrition and Sarcopenia—What Do We Know?

2020

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“…When assessing muscle mass and functional outcomes in mobility-limited older adults completing 6 months of progressive high-intensity RET, consuming 40 g whey protein daily had no greater effect on lean mass or strength than the isocaloric (but not isoproteic) control [75]. In contrast, a recent study by Kang et al [76] reported that following daily whey protein (32.4 g) supplementation in frail older adults undergoing 12 weeks of RET, grip strength, chair-to-stand time and gait speed improved to a greater extent in the whey protein supplementation group than in the RET only group. This data suggests that animal-derived protein can positively influence muscle function.…”

Section: Skeletal Musclementioning

confidence: 79%

Animal, Plant, Collagen and Blended Dietary Proteins: Effects on Musculoskeletal Outcomes

et al. 2020

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Dietary protein is critical for the maintenance of musculoskeletal health, whereappropriate intake (i.e., source, dose, timing) can mitigate declines in muscle and bone mass and/orfunction. Animal-derived protein is a potent anabolic source due to rapid digestion and absorptionkinetics stimulating robust increases in muscle protein synthesis and promoting bone accretion andmaintenance. However, global concerns surrounding environmental sustainability has led to anincreasing interest in plant- and collagen-derived protein as alternative or adjunct dietary sources.This is despite the lower anabolic profile of plant and collagen protein due to the inferior essentialamino acid profile (e.g., lower leucine content) and subordinate digestibility (versus animal). Thisreview evaluates the efficacy of animal-, plant- and collagen-derived proteins in isolation, and asprotein blends, for augmenting muscle and bone metabolism and health in the context of ageing,exercise and energy restriction.

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“…Of the remaining citations, 7 were nutrition RCTS 8,22,24-28 and 7 were combined-approach RCTs or clinical controlled trials. [29][30][31][32][33][34][35] We meta-analyzed all 15 studies and their outcomes based on their intervention category. The studies were published from 2000 to 2019.…”

Section: Resultsmentioning

confidence: 99%

“…The nutrition component of combined-approach interventions [29][30][31][32][33]35 consisted of protein supplementation, provision of food, vitamin D supplementation, dietary counselling, education or cooking classes. The physical activity component was mostly muscle-strengthening exercises through resistance and strength training, but 3 interventions 23,30,34 also included aerobic exercises (Appendix 4, Supplemental Table S2).…”

Section: Combined-approach Interventionsmentioning

confidence: 99%

“…The same 6 interventions had data for both physical and mobility meaures. [29][30][31][32][33]35 These interventions involved 258 intervention and 256 control participants and ranged in duration from 12 to 52 weeks. They had small but significant pooled effect estimates for physical measures (SMD 0.19, 95% CI 0.06 to 0.32) (Figure 4A) and mobility measures (SMD 0.25, 95% CI 0.02 to 0.48) (Figure 4B).…”

Section: Combined-approach Interventionsmentioning

confidence: 99%

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Effectiveness of nutrition interventions and combined nutrition and physical activity interventions in older adults with frailty or prefrailty: a systematic review and meta-analysis

Racey

Ali

Sherifali

et al. 2021

cmajo

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railty is a leading contributor to functional decline and early death in older adults. 1 More than 1.5 million Canadians are estimated to be diagnosed as medically frail, and this number is expected to rise to more than 2 million in the next 10 years. 2 Frailty is a syndrome resulting from multiple factors and impairments that can reduce a person's functional ability. It is characterized by reductions in physiologic reserve and a reduced ability to respond to stress. 3,4 Older adults with frailty are at increased risk for

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Effects of whey protein nutritional supplement on muscle function among community-dwelling frail older people: A multicenter study in China

Cited by 38 publications

References 15 publications

Nutrition and Sarcopenia—What Do We Know?

Nutrition and Sarcopenia—What Do We Know?

Animal, Plant, Collagen and Blended Dietary Proteins: Effects on Musculoskeletal Outcomes

Effectiveness of nutrition interventions and combined nutrition and physical activity interventions in older adults with frailty or prefrailty: a systematic review and meta-analysis

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