Effects of Weight Loss on the Hormonal Profile in Obese, Infertile Women

Hollmann, M.; Runnebaum, B.; Gerhard, I.

doi:10.1097/00006254-199705000-00017

Cited by 56 publications

(75 citation statements)

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“…1,29,36,48 We previously found a pregnancy rate of 29% and an improvement of menstrual dysfunction in 80% in obese, infertile women after simple weight reduction. 29 Further controlled studies are necessary to investigate whether weight loss, pregnancy rate and changes of menstrual dysfunction generally differ depending on the body fat distribution.…”

Section: Discussionmentioning

confidence: 97%

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Impact of waist-hip-ratio and body-mass-index on hormonal and metabolic parameters in young, obese women

1997

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BACKGROUND: To investigate the impact of predominantly upper body fat localisation on the hormonal and metabolic pro®le in obese, infertile women. DESIGN: Prospective observational study of premenopausal women with obesity, infertility and menstrual dysfunction. SETTING: Department of Endocrinology and Reproduction of the University Hospital of Obstetrics and Gynaecology of Heidelberg. SUBJECTS: Eighteen women with android type obesity (waist-hip-ratio WHR b 0.85, group 1) and 22 women with gynoid type obesity (WHR 0.85, group 2) in a group of 58 premenopausal obese women (median age 28 y) with infertility. Twenty-nine women took part in a weight reducing program lasting 32 AE 14 (mean AE s.d.) weeks. MEASUREMENTS: BMI, WHR and blood pressure. Plasma lipids and liver enzymes. Blood glucose, insulin, C-peptide and different steroid and pituitary hormones during oral glucose loading. RESULTS: In the total group of 58 obese women, WHR was directly correlated to plasma triglycerides, AST, ALT and cholesterol/HDL-cholesterol-ratio. WHR correlated inversely with HDL-cholesterol. Insulin resistance was greater with increasing WHR. Systolic blood pressure, glucose, insulin, C-peptide, triglycerides, cholesterol/HDL-cholesterol-ratio, aspartate (AST) and alanine aminotransferase (ALT) were signi®cantly greater in group 1. Group 2 had greater HDLcholesterol levels. One subject in group 1, ®ve women in group 2 conceived spontaneously after weight reduction. CONCLUSIONS: Determination of the WHR is a simple measurement to identify obese patients who are at a greater risk of developing the metabolic syndrome. WHR is important in preventive medicine, as typical metabolic pro®les are already present in young women before clinical manifestation. Women with android obesity seem to be more prone to develop menstrual irregularity and infertility. The hyperinsulinaemia may be the pathway.

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Section: Discussionmentioning

confidence: 97%

“…We previously found a pregnancy rate of 29% and an improvement of menstrual dysfunction in 80% in obese, infertile women after weight reduction. 29 …”

Section: Introductionmentioning

confidence: 99%

Impact of waist-hip-ratio and body-mass-index on hormonal and metabolic parameters in young, obese women

1997

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“…У жен-щин репродуктивного возраста МС является од-ной из наиболее частых причин ановуляторного бесплодия, ранних потерь беременности. Частота данной патологии составляет примерно 30-35 % в структуре нарушений репродуктивной функции и до 70 % среди пациенток с рецидивирующи-ми гиперпластическими процессами эндомет-рия [5].…”

Section: актуальностьunclassified

The Menstrual Disorders in Women of Reproductive Age with Obesity

Ахмедова

Садыкова

2021

Mìžnarodnij endokrinologìčnij žurnal

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АктуальностьОжирение является гипоталамо-гипофизарным заболеванием, в патогенезе которого ведущую роль играют выраженные в той или иной степени гипо-таламические нарушения, обусловливающие изме-нение поведенческих реакций, особенно пищевого поведения, и гормональные нарушения. При этом возрастает активность гипоталамо-гипофизарно-надпочечниковой системы: увеличиваются секреция адренокортикотропного гормона (АКТГ), скорость продукции кортизола, ускоряется его метаболизм. Снижается секреция соматотропного гормона, обла-дающего липолитическим действием, нарушается се-креция гонадотропинов и половых стероидов. Харак-терны гиперинсулинемия, снижение эффективности действия инсулина. Нарушается метаболизм тирео-идных гормонов и чувствительность периферических тканей к ним [3].Адрес для переписки с авторами: Ахмедова Шахноза Улугбековна

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“…However, not all patients equally respond to these measures even if their weight loss is similar [24]. Hollmann et al describe an 80% improvement in ovulation rate and 29% in the pregnancy rate in the case of a 10% weight loss [32].…”

Section: Reproductive Potentialmentioning

confidence: 99%

Lifestyle Changes and Weight Loss: Effects in PCOS

Ionescu¹,

Popescu²,

Banacu³

et al. 2018

Debatable Topics in PCOS Patients

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Even though controversies surrounding the polycystic ovary syndrome are not yet close to be solved, its clinical manifestations are well known-insulin resistance and obesity, hirsutism, irregular and anovulatory menstrual cycles. The treatment of polycystic ovarian syndrome (PCOS) is mainly symptomatic as its etiology is not yet clear. Lifestyle changes are the primary therapy in overweight and obese women with PCOS. According to majority of the studies, lifestyle changes are the most efective form of treatment not only for weight loss but also for the improvement of insulin sensitivity, decreasing incidence of metabolic syndrome and type 2 diabetes. Studies also show that weight loss has fertility beneits by restoring ovulatory cycles. Although initial studies researching pharmacologic treatment were showing excellent results concerning the weight loss, maintenance of weight loss and reduction of cardiovascular risks, some of these drugs were in the end, has proven to actually increase the risk for cardiovascular events and were removed from the market. Bariatric surgery has been demonstrated to improve or even cure type 2 diabetes, hypertension, hyperlipidemia, and obstructive sleep apnea. More so, there are studies that reported complete resolution of all features of PCOS, even hirsutism, hyperandrogenism, anovulation, and menstrual irregularity.

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Effects of Weight Loss on the Hormonal Profile in Obese, Infertile Women

Cited by 56 publications

References 0 publications

Impact of waist-hip-ratio and body-mass-index on hormonal and metabolic parameters in young, obese women

Impact of waist-hip-ratio and body-mass-index on hormonal and metabolic parameters in young, obese women

The Menstrual Disorders in Women of Reproductive Age with Obesity

Lifestyle Changes and Weight Loss: Effects in PCOS

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