Effects of weight loss on erythrocyte membrane composition and fluidity in overweight and moderately obese women

Influence of age on the correlations of hematological and biochemical variables with the stability of erythrocyte membrane in relation to sodium dodecyl sulfate

“…37 Furthermore, a decrease in the blood levels of cholesterol is associated to a lower ratio between cholesterol and phospholipids in the membrane, with physicochemical changes as increased membrane fluidity. 38 These reports from the literature are consistent with the correlations found in this study between the stability variables and the blood concentrations of LDL-C in the bivariate and multivariate correlation analyses.…”

Global Metabolic Profiling of Plasma Shows that Three-Year Mild-Caloric Restriction Lessens an Age-Related Increase in Sphingomyelin and Reduces L-leucine and L-phenylalanine in Overweight and Obese Subjects

“…The decreased level of SM (d18:0/16:1) in the MCD group is similar to that of a recent weight-loss study of an 8-week LCD in overweight and moderately obese women [22]. In terms of plasma lipoproteins, SM is the second-most abundant polar lipid after PC [22].…”

“…In terms of plasma lipoproteins, SM is the second-most abundant polar lipid after PC [22]. The proportion of plasma SM increases with age, and it is elevated in an obese model [23-26].…”

“…Therefore, decreased levels of these 3 metabolites after dietary intervention in our study may explain the preventive effects of long-term mild caloric restriction on IR. Cazzola et al [22] investigated the effects of LCD on erythrocyte membrane properties, and they suggested that the decreased SM in the erythrocyte membrane composition of the LCD-induced weight loss group could reflect a virtuous cycle resulting from the reduction in IR associated with increased membrane fluidity that, in turn, results in a sequence of metabolic events that concur to further improve membrane fluidity.…”

Buffered vs. Non-Buffered Aliphatic Fatty Acids and their Anti-Proliferative Effects in Human Tumor Cell Lines

“…Studies have shown that in both whole organisms, as well as in cell cultures, saturated and unsaturated fats have the ability to impact a number of tissue and cellular metabolic functions [2][3][4][5][6]. The suggested mechanisms, by which these processes may be occurring, are thought to involve changes in cell membrane fluidity, and cell membrane receptor availability [7][8][9][10], as well as suppression, or up-regulation of cell-to-cell growth factor signaling [1,11,12], and inflammatory factor generation [13,14]. Saturated vs. unsaturated lipid mediated cellular behavioral changes have been shown to impact the overall behavior [15] and the fluidity of peripheral muscle tissue.…”