Effects of Weight Loss on Airway Responsiveness in Obese Adults With Asthma

Pakhalé, Smita; Baron, Justine; Dent, Robert; Vandemheen, Katherine L.; Aaron, Shawn D.

doi:10.1378/chest.14-3105

Cited by 73 publications

(60 citation statements)

References 30 publications

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“…Improvements were seen in asthma symptoms, quality of life, peak flow, and markers of oxidative stress and inflammation. 64 More recent studies published by Pakhale et al, 65 Scott et al, 66 and Ma et al 68 implementing weight loss in the form of liquid diet (Pakhale), or diet and exercise (Scott and Ma), suggest improved asthma outcomes in patients who lose a significant amount of weight. There appears to be a threshold for improving asthma symptoms, with a 5%-10% loss of body weight required to significantly improve asthma control.…”

Section: Evidence That Weight Loss Improves Asthma Controlmentioning

confidence: 99%

“…62 A summary of these studies is described in Table 3. [63][64][65][66][67][68][69] Although the quality and sample size of these studies vary, the majority of these studies have found improvements in asthma-related quality of life, lung function, and symptom scores with significant weight loss. 62,63 Weight loss studies have included surgery, low calorie diets, exercise, and combined diet-exercise interventions.…”

Section: Evidence That Weight Loss Improves Asthma Controlmentioning

confidence: 99%

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The Asthma–Obesity Epidemic

Dixon¹

2015

Primary Prevention Insights

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Obesity is a risk factor for the development of asthma. Understanding this link between obesity and asthma has major public health implications for developing strategies to prevent the development of asthma and to guide the management of such patients. Obese patients with asthma experience poor asthma control, worse asthma-specific quality of life, and limited response to corticosteroids. This review provides a succinct summary of the current body of literature on the epidemiological relationship between asthma and obesity, the different phenotypes of asthma in obesity, and data on the efficacy of weight loss and discusses the potential role of primary prevention efforts for the current asthma epidemic.

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Section: Evidence That Weight Loss Improves Asthma Controlmentioning

confidence: 99%

Section: Evidence That Weight Loss Improves Asthma Controlmentioning

confidence: 99%

The Asthma–Obesity Epidemic

Dixon¹

2015

Primary Prevention Insights

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“…Physical activity levels also increased significantly in the intervention group but not in the control group. 3 …”

Section: Asthma and Obesitymentioning

confidence: 99%

Asthma 2015: The Year in Review

Rubin

2016

Respir Care

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Between January 1, 2015, and the end of October, there were >6,500 peer-reviewed papers listed in PubMed on asthma. Of necessity, those that have been selected for inclusion for this Year in Review represent a few that have caught the reviewer's interest, organized by themes. Not unexpectedly, some of these papers are in conflict with each other, whereas others raise more questions then they appear to answer. All in all, it has been a busy year in the asthma world and with new medications reaching the market in coming years, it is unlikely that this interest will abate.

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“…Moreover, regarding nutritional status, individuals with extreme nutritional imbalance -with body mass index (BMI) indicating low weight and obesity, tend to be more prone to develop respiratory diseases when compared to those with normal BMI (Genc et al, 2014;Humphreys, et al, 2014;Liu, Roberts, Moyer-Mileur, & Samson-Fang, 2005;Paulo, et al, 2015;Thakker, 2014). Studies show that when affected by a respiratory disease the individuals need to include exercise in their routines and keep their BMI within the normal range due to its positive impact on maintenance, treatment and prevention of comorbidities (Demeyer et al, 2014;Fenger et al, 2014;Pakhale, Baron, Dent, Vandemheen, & Aaron, 2015). However, it is perceived a scarcity of studies comparing long-term impact of physical activity on lung function among practitioners of regular physical activity with no complaints or history of lung disease.…”

Section: Introductionmentioning

confidence: 99%

Lung Function in Adults: Relationship between Time Practice of Physical Activity and Nutritional Status

SILVA¹

2016

IntJSCS

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Background: Much is said about the importance of physical activity to improve lung function in people with some kind of respiratory disease, however, there are few studies comparing long-term impact of physical activity on lung function among regular physical activity practitioners without complaints or history of lung disease. The objective of this study was to observe the relationship between time of physical activity, nutritional status and lung function variables in Brazilian adults. Methods: a descriptive exploratory study was conducted with 799 individuals (268 men and 531 women) aged between 18 and 59 years old who participate in physical activity programs offered by a municipal sports and recreation department. The volunteers were subjected to forced spirometry test to collect data concerning: values of Forced Vital Capacity (FVC), Forced Expiratory Volume on the first second (FEV1) and Peak Expiratory Flow (PEF). Additionally, body mass and height were identified using digital scale with coupled stadiometer to calculate the body mass index (BMI= kg/m²). This index was used to grade individuals into three categories: normal nutritional status, overweight or obese. A questionnaire on regular physical activity practice time was also applied. Data were processed adopting a 5% significance level. Results: There was significant association between nutritional status and pulmonary function test (x²= 16.39; p= 0.003) for men. An association between increased BMI and the risk of restrictive lung disease was confirmed. In women the figures were x²= 3.41 (p= 0.492). Additionally, there was no significant association between pulmonary function test and time of physical activity in either gender. Conclusion: In this study, the nutritional status confirms its interference on respiratory function, even among regular practitioners of physical activity, and spirometric results suggest that long-term physical activity does not promote significant changes on lung function.

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Effects of Weight Loss on Airway Responsiveness in Obese Adults With Asthma

Cited by 73 publications

References 30 publications

The Asthma–Obesity Epidemic

The Asthma–Obesity Epidemic

Asthma 2015: The Year in Review

Lung Function in Adults: Relationship between Time Practice of Physical Activity and Nutritional Status

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Effects of Weight Loss on Airway Responsiveness in Obese Adults With Asthma

Cited by 73 publications

References 30 publications

The Asthma&ndash;Obesity Epidemic

The Asthma&ndash;Obesity Epidemic

Asthma 2015: The Year in Review

Lung Function in Adults: Relationship between Time Practice of Physical Activity and Nutritional Status

Contact Info

Product

Resources

About

The Asthma–Obesity Epidemic

The Asthma–Obesity Epidemic