Effects of weak static magnetic fields on the gene expression of seedlings of Arabidopsis thaliana

Dhiman, Sunil Kumar; Galland, Paul

doi:10.1016/j.jplph.2018.08.016

Cited by 39 publications

(33 citation statements)

References 47 publications

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“…www.nature.com/scientificreports www.nature.com/scientificreports/ In conclusion, this study shows that RF magnetic fields alter the biological response characteristics of the Arabidopsis cryptochrome receptor itself, similarly to the effects of a near-null magnetic field. These results are consistent with the radical pair mechanism for magnetosensing and cannot be explained by an iron -based magnetosensor 13,20 , although we can not exclude that unrelated magnetosensing mechanisms exist in parallel 6,25,26 , or that cry may not be the direct RF receptor. Since cryptochromes are found in many organisms in the biological Kingdom including in humans, this study may lead to new biomedical applications developing RF signals to elicit desired cellular responses.…”

Section: 23supporting

confidence: 69%

Arabidopsis cryptochrome is responsive to Radiofrequency (RF) electromagnetic fields

Albaqami

Hammad

Pooam

et al. 2020

Sci Rep

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How living systems respond to weak electromagnetic fields represents one of the major unsolved challenges in sensory biology. Recent evidence has implicated cryptochrome, an evolutionarily conserved flavoprotein receptor, in magnetic field responses of organisms ranging from plants to migratory birds. However, whether cryptochromes fulfill the criteria to function as biological magnetosensors remains to be established. Currently, theoretical predictions on the underlying mechanism of chemical magnetoreception have been supported by experimental observations that exposure to radiofrequency (RF) in the MHz range disrupt bird orientation and mammalian cellular respiration. Here we show that, in keeping with certain quantum physical hypotheses, a weak 7 MHz radiofrequency magnetic field significantly reduces the biological responsivity to blue light of the cryptochrome receptor cry1 in Arabidopsis seedlings. Using an in vivo phosphorylation assay that specifically detects activated cryptochrome, we demonstrate that RF exposure reduces conformational changes associated with biological activity. RF exposure furthermore alters cryptochrome-dependent plant growth responses and gene expression to a degree consistent with theoretical predictions. To our knowledge this represents the first demonstration of a biological receptor responding to RF exposure, providing important new implications for magnetosensing as well as possible future applications in biotechnology and medicine.

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Section: 23supporting

confidence: 69%

Arabidopsis cryptochrome is responsive to Radiofrequency (RF) electromagnetic fields

Albaqami

Hammad

Pooam

et al. 2020

Sci Rep

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“…For instance, Dhiman and Galland [2018] reported that the expression of a plant gene from several genes studied could either increase or decrease by a factor of 5–40 when MF changed by 8 μT. In Novikov et al [2020], MFs of 1 and 2.5 µT demonstrated opposite‐sign effects on the fluorescence in the neutrophil suspension.…”

Section: Randomness Of Nonspecific Effectsmentioning

confidence: 99%

Random Effects in Magnetobiology and a Way to Summarize Them

Binhi

2021

Bioelectromagnetics

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In magnetobiology, it is difficult to reproduce the nonspecific (not associated with specialized receptors) biological effects of weak magnetic fields. This means that some important characteristic of the data may be missed in standard statistical processing, where the set of measurements to be averaged belongs to the same population so that the contribution of fluctuations decreases according to the Central Limit Theorem. It has been shown that a series of measurements of a nonspecific magnetic effect contains not only the usual scatter of data around the mean but also a significant random component in the mean itself. This random component indicates that measurements belong to different statistical populations, which requires special processing. This component, otherwise called heterogeneity, is an additional characteristic that is typically overlooked, and which reduces reproducibility. The current method for studying and summarizing highly heterogeneous data is the random‐effect meta‐analysis of absolute values, i.e., of magnitudes, rather than the values themselves. However, this estimator—the average of absolute values—has a significant positive bias when it comes to the small effects that are characteristic of magnetobiology. To solve this problem, an improved estimator based on the folded normal distribution that gives several times less bias is proposed. We used this improved estimator to analyze the nonspecific effect of the hypomagnetic field in the Stroop test in 40 subjects and found a statistically significant meta‐effect with a standardized average of magnitudes of about 0.1. It has been shown that the proposed approach can also be applied to a single study. © 2021 Bioelectromagnetics Society.

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“…In addition, some of the primary MF sensors reside on rotating molecules [ 67 ]. According to the available literature data, responses to a weak constant MF are well pronounced in those organisms in which the processes of gene expression are most active (e.g., [ 27 ]), while nonthermal rotations of RNA, DNA, enzymes, synthesized proteins, etc., accompany gene expression.…”

Section: Can the Sensitivity Of Organisms To Tens Of Nt Be Explained?mentioning

confidence: 99%

Theoretical Concepts in Magnetobiology after 40 Years of Research

Binhi

Rubin

2022

Cells

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This review contains information on the development of magnetic biology, one of the multidisciplinary areas of biophysics. The main historical facts are presented and the general observed properties of magnetobiological phenomena are listed. The unavoidable presence of nonspecific magnetobiological effects in the everyday life of a person and society is shown. Particular attention is paid to the formation of theoretical concepts in magnetobiology and the state of the art in this area of research. Some details are provided on the molecular mechanisms of the nonspecific action of a magnetic field on organisms. The prospects of magnetobiology for the near and distant future are discussed.

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Effects of weak static magnetic fields on the gene expression of seedlings of Arabidopsis thaliana

Cited by 39 publications

References 47 publications

Arabidopsis cryptochrome is responsive to Radiofrequency (RF) electromagnetic fields

Arabidopsis cryptochrome is responsive to Radiofrequency (RF) electromagnetic fields

Random Effects in Magnetobiology and a Way to Summarize Them

Theoretical Concepts in Magnetobiology after 40 Years of Research

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