Effects of water-immersion stress on gastric secretion and mucosal blood flow in rats

Kitagawa, Hisato; Fujiwara, Motohatsu; Osumi, Yoshitsugu

doi:10.1016/0016-5085(79)90281-6

Cited by 188 publications

(50 citation statements)

References 22 publications

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“…Our study outcomes however differed from these previous investigations possibly since we are demonstrating the changes in gastrin level following ulcer induction by cold and restrain treatment in rats. As it is already known, the incidence of stomach injuries in CRU rats was mainly dependent on acid secretion and gastrin is reported to be involved in the stimulation of gastric acid secretion under vagal activation in CRU model (Kitagawa et al 1979). Thus, it might be possible that gastrin can exerts its gastroprotective effects only during undisturbed acidic circumstances (as in ethanol induced stomach lesions), while under agitated acidic settings (CRU induced gastric injury), it act to stimulate acid secretions, and in this manner contributes to the pathomechanism of mucosal injury.…”

Section: Discussionmentioning

confidence: 97%

“…The compound was noted to be as efficient as reference drug, omeprazole, in reducing the gastric lesions in CRU model. Cold and restraint stress alters the regulation of acid secretion, and it increases the acidity of gastric juice through vagal activation (Kitagawa et al 1979). Thus, the significant protection imparted by rohitukine in this model reflected the possibility of its involvement in the regulatory mechanism of gastric acid secretion.…”

Section: Discussionmentioning

confidence: 98%

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Gastroprotective effect of anti-cancer compound rohitukine: possible role of gastrin antagonism and H+ K+-ATPase inhibition

Singh

Shrivastva

et al. 2011

Naunyn-Schmiedeberg's Arch Pharmacol

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The present study was designed to evaluate the anti-ulcerogenic properties of an alkaloid chromane, rohitukine from Dysoxylum binectariferum. Anti-ulcer potential of rohitukine was assessed in cold restrained, pyloric ligated and ethanol induced ulcers in rats. In addition, rohitukine was tested in vitro for H(+) K(+)-ATPase inhibitory activity in gastric microsomes. Moreover, we studied the role of rohitukine on the cytosolic concentration of Ca(2+) in parietal cell-enriched cell suspension in order to ascertain its mechanism of action. Cytoprotective activity was evaluated through PGE(2) level. Rohitukine significantly attenuated the ulcers in cold restraint ulcer (CRU) model in a dose-related manner. Moreover, it significantly lowered the free acidity and pepsin activity in pyloric ligated rats while improved the depleted level of mucin. Furthermore, rohitukine significantly reversed the cold restrained-induced increase in gastrin level. Our in vitro study revealed that rohitukine moderately inhibited the microsomal H(+) K(+)-ATPase activity with respect to positive control omeprazole. Furthermore, rohitukine potently antagonized the gastrin-elicited increase in cytosolic Ca(2+) level in parietal cell-enriched suspension. In ethanol-induced gastric lesions in rats, rohitukine significantly inhibited the formation of erosions and increased PGE(2) content showing more potency than reference drug sucralfate. Our results thus suggest that rohitukine possess significant anti-ulcer and anti-gastrinic activity in rats. It is likely that gastro-protective influences of rohitukine are dependent partly on its acid-lowering potential and partly on cytoprotective property. The acid-reducing effect of rohitukine might be attributed to its lowering effect on gastrin production and/or antagonism of gastrin-evoked functional responses of parietal cells. Thus, rohitukine represent a useful agent in the treatment of peptic ulcer disease.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

Gastroprotective effect of anti-cancer compound rohitukine: possible role of gastrin antagonism and H+ K+-ATPase inhibition

Singh

Shrivastva

et al. 2011

Naunyn-Schmiedeberg's Arch Pharmacol

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“…Reported mechanisms of acute stress-induced gastric mucosal injury include decreased in situ PGs, 29 increased acid secretion, 30 disturbed microcirculation in the gastric mucosa, 31 suppressed cell cycles, 32 and increased motility of the stomach. 33 In particular, ischemia-reperfusion injury is considered important when there is disturbed blood flow or reperfusion, because active oxygen is produced in the tissue or by neutrophils.…”

Section: Discussionmentioning

confidence: 99%

The protective and hormonal effects of proanthocyanidin against gastric mucosal injury in Wistar rats

2004

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Proanthocyanidin was shown to have a protective effect on the gastric mucosa. The mechanisms underlying the effect of proanthocyanidin were considered to be the following: anti-gastrin and anti-histamine effects to prevent attacks by water-immersion restraint stress, and mucoprotective properties, bestowed by increased prostaglandin and increased superoxide dismutase activities in the gastric mucosa.

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“…The contribution of gastric neutrophil accumulation, inflammatory cytokine production, free radical production, decreased mucosal blood flow, and increased acid secretion have been reported to be involved in the pathogenesis of stress-induced gastric lesions, although the most important factors for the development of these lesions have not been well elucidated. [1][2][3] Recent studies have revealed that neutralizing antibody against tumor necrosis factor-a (TNF-a) inhibits the gastric lesions and neutrophil accumulation induced by water-immersion stress. 4 We have reported that an inhibitor of pro-inflammatory cytokine production, FR167653, reduces the severity of experimentally induced colonic mucosal lesions.…”

Section: Introductionmentioning

confidence: 99%

Effect of cilostazol, a selective type-III phosphodiesterase inhibitor, on water-immersion stress-induced gastric mucosal injury in rats

et al. 2006

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Effects of water-immersion stress on gastric secretion and mucosal blood flow in rats

Cited by 188 publications

References 22 publications

Gastroprotective effect of anti-cancer compound rohitukine: possible role of gastrin antagonism and H+ K+-ATPase inhibition

Gastroprotective effect of anti-cancer compound rohitukine: possible role of gastrin antagonism and H+ K+-ATPase inhibition

The protective and hormonal effects of proanthocyanidin against gastric mucosal injury in Wistar rats

Effect of cilostazol, a selective type-III phosphodiesterase inhibitor, on water-immersion stress-induced gastric mucosal injury in rats

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