Effects of Water Extract from Artemisia argyi Leaves on LPS-Induced Mastitis in Mice

Ma, Qianbo; Wei, Yuanhao; Meng, Zitong; Chen, Yuhua; Zhao, Guoqi

doi:10.3390/ani12070907

Cited by 5 publications

(3 citation statements)

References 38 publications

(39 reference statements)

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“…For instance, Welz et al [ 64 ], showed that dissatisfaction with conventional treatment was the most important reason for use of herbal remedies. There are many reported cases of conventional drug failures due to drug resistance [ 12 , 65 ]. Of late, a lot of scientific investigations have been carried out on herbal medicine confirming their efficacy in certain conditions hence the several phyto-pharmaceutical products on the market [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Ethnobotanical study of medicinal plants utilized in the management of candidiasis in Northern Uganda

et al. 2022

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Background The emergence of resistant Candida species to antifungal drugs has led to resurgence in herbal usage globally. However, little is known about anti-candida plants. This study explored ethnomedicinal plants as treatment option for candidiasis in Pader, Northern Uganda. Methods A cross-sectional survey of potential anti-candida plants was conducted using questionnaires, focus group discussions and field observations in March 2022. Sixty-three respondents were selected by snowball technique. The frequencies of respondents/responses were analyzed, associations of respondents’ socio-demographics with indigenous knowledge of herbal usage established by Chi-square (χ2) test using SPSS 27. Informant Consensus Factor was computed to establish level of agreement on herbal usage, and thematic analysis done for focus group discussions. Results Candidiasis is still common and troublesome in Pader. All herbalist had equal chances of receiving and treating candidiasis patients irrespective of herbalist’s gender, age, education level, occupation, marital status and religion (p > 0.05). About 39.7% of herbalists received candidiasis patients weekly (p < 0.01). All herbalists had knowledge on candidiasis. Death (56.8%) and discomfort (36.8%) were the major health risks of oropharyngeal candidiasis (OPC) and vulvovaginal candidiasis (VVC), respectively. A total of 32 potential anti-candida plant species in 18 families were identified. Families of Fabaceae (9 species) and Asteraceae (5 species) had most plant species. Trees (50.0%) and herbs (43.8%) were the dominant life forms. The commonest plants by frequency of mention were: Momordica foetida (26), Sansevieria dawei (20), Khaya anthotheca (15), Piliostigma thonningii (10), Clerodendrum umbellatum (7), Hallea rubrostipulata (5) and unidentified plant, ‘Agaba/daa layata’ in Acholi dialect (5). Plant parts mainly used were roots (56.3%) and stem barks (15.6%) harvested majorly by cutting (46.9%) and uprooting (12.5%). Most respondents (females, 95%) preferred herbal to western medication (p < 0.01) due to its perceived effectiveness. There was high consensus among herbalists on herbal remedies for OPC and VVC (FIC = 0.9). Conclusions Pader communities have diverse indigenous knowledge on candidiasis and prefer herbal medicines to orthodox treatment for candidiasis. However, the herbalists use unsustainable harvesting techniques like uprooting whole plants and cutting main roots. Hence, the need to document such indigenous knowledge before being lost for community usage and scientific validation.

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Section: Discussionmentioning

confidence: 99%

Ethnobotanical study of medicinal plants utilized in the management of candidiasis in Northern Uganda

et al. 2022

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“…Several lines of evidence supported that neuroinflammatory mechanisms are involved in the pathogenesis of neurodegenerative disorders like AD. Induction of inflammatory conditions by an exogenous stimulant like LPS is well studied and it has been described that LPS administration alleviates the level of pro-inflammatory mediators and other cytokines ( 51 , 52 ). The release of these inflammatory cytokines like TNF-α, IL-1β, NOS-2, and prostaglandins are the intermediary mediators to induce neuronal injury and apoptosis ( 53 , 54 ).…”

Section: Discussionmentioning

confidence: 99%

Lupeol protect against LPS-induced neuroinflammation and amyloid beta in adult mouse hippocampus

Choe,

Park,

Park

et al. 2024

Front. Nutr.

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Neuroinflammation includes the activation of immune glial cells in the central nervous system, release pro-inflammatory cytokines, which disrupt normal neural function and contribute to various neurological disorders, including Alzheimer’s disease (AD), Parkinson’s disease, multiple sclerosis, and stroke. AD is characterized by various factors including amyloidogenesis, synaptic dysfunction, memory impairment and neuroinflammation. Lipopolysaccharide (LPS) constitutes a vital element of membrane of the gram-negative bacterial cell, triggering vigorous neuroinflammation and facilitating neurodegeneration. Lupeol, a naturally occurring pentacyclic triterpene, has demonstrated several pharmacological properties, notably its anti-inflammatory activity. In this study, we evaluated the anti-inflammatory and anti-Alzheimer activity of lupeol in lipopolysaccharide (LPS)-injected mice model. LPS (250ug/kg) was administered intraperitoneally to C57BL/6 N male mice for 1 week to induce neuroinflammation and cognitive impairment. For biochemical analysis, acetylcholinesterase (AChE) assay, western blotting and confocal microscopy were performed. AChE, western blot and immunofluorescence results showed that lupeol treatment (50 mg/kg) along with LPS administration significantly inhibited the LPS-induced activation of neuroinflammatory mediators and cytokines like nuclear factor (NF-κB), tumor necrosis factor (TNF-α), cyclooxygenase (COX-2) and interleukin (IL-1β). Furthermore, we found that LPS-induced systemic inflammation lead to Alzheimer’s symptoms as LPS treatment enhances level of amyloid beta (Aβ), amyloid precursor protein (APP), Beta-site APP cleaving enzyme (BACE-1) and hyperphosphorylated Tau (p-Tau). Lupeol treatment reversed the LPS-induced elevated level of Aβ, APP, BACE-1 and p-Tau in the hippocampus, showing anti-Alzheimer’s properties. It is also determined that lupeol prevented LPS-induced synaptic dysfunction via enhanced expression of pre-and post-synaptic markers like SNAP-23, synaptophysin and PSD-95. Overall, our study shows that lupeol prevents memory impairment and synaptic dysfunction via inhibition of neuroinflammatory processes. Hence, we suggest that lupeol might be a useful therapeutic agent in prevention of neuroinflammation-induced neurological disorders like AD.

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“…Many studies have reported that various extracts of A. argyi possess antioxidant, antibacterial, and immunomodulatory properties [ 7 , 44 , 45 ]. A previous study suggested that A. argyi water extract plays a positive role in lipopolysaccharide-induced oxidative stress by restoring the activities of GPx and SOD, and preventing the increase in nitric oxide concentration caused by the over-activation of total nitric oxide synthase [ 46 ]. Consistent with these results, the present study showed that A. argyi water extract significantly increased hepatic PON, GR, and GPx activity and decreased hepatic TBARS levels.…”

Section: Discussionmentioning

confidence: 99%

Artemisiae argyi Water Extract Alleviates Obesity-Induced Metabolic Disorder

Han

Park

Hong

et al. 2022

CIMB

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Artemisiae argyi is a well-known traditional herbal medicine used in East Asia. Although the antibacterial and anti-inflammatory effects of A. argyi have been reported, its efficacy in improving obesity has not been yet evaluated. In this study, mice were fed a normal diet (AIN-93), a high-fat diet (HFD, 60% of kcal from fat), and an HFD with 0.1% of A. argyi water extract for 16 weeks. The body weight and body fat in A. argyi-fed mice significantly decreased via upregulation of the mRNA expression of fatty acid oxidation-related genes, with a simultaneous decrease in plasma lipid content and leptin levels. A. argyi water extract also ameliorated hepatic steatosis by restricting lipogenesis via lowering the activities of fatty acid synthase and phosphatidic acid phosphatase. Consistently, hepatic histological analysis indicated that A. argyi water extract decreased hepatic lipid accumulation in accordance with the hepatic H, E and Oil Red O-stained area. Additionally, A. argyi ameliorated the impaired glucose homeostasis by increasing the mRNA expression of AMP-activated kinase and glycolysis-related genes. In conclusion, our results indicate that A. argyi can be used to treat obesity-related metabolic conditions.

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Effects of Water Extract from Artemisia argyi Leaves on LPS-Induced Mastitis in Mice

Cited by 5 publications

References 38 publications

Ethnobotanical study of medicinal plants utilized in the management of candidiasis in Northern Uganda

Ethnobotanical study of medicinal plants utilized in the management of candidiasis in Northern Uganda

Lupeol protect against LPS-induced neuroinflammation and amyloid beta in adult mouse hippocampus

Artemisiae argyi Water Extract Alleviates Obesity-Induced Metabolic Disorder

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