Effects of washing of the face with a mild facial cleanser formulated with sodium laureth carboxylate and alkyl carboxylates on acne in Japanese adult males

Isoda, Kenichi; Takagi, Yutaka; Endo, Koji; Miyaki, Masahiro; Matsuo, Kazuya; Umeda, Koji; Umeda-Togami, Kumi; Mizutani, Hitoshi

doi:10.1111/srt.12183

Cited by 16 publications

(24 citation statements)

References 21 publications

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“…We demonstrated that following use of the AEC/AC cleanser, acne lesions were significantly improved. This is similar to a study conducted on male Japanese subjects . It is presumed that this improvement might be caused by the higher sebum‐cleansing ability of these cleansers compared with soap, as shown in Figure .…”

Section: Discussionsupporting

confidence: 88%

“…The AEC/AC‐formulated cleanser did not induce dry skin . In the present trial, there were no complaints about facial dryness, and in fact, 4 of the 17 subjects reported that their skin became less dry.…”

Section: Discussionmentioning

confidence: 38%

“…This is similar to a study conducted on male Japanese subjects. 11 It is presumed that this improvement might be caused by the higher sebum-cleansing ability of these cleansers compared with soap, as shown in Figure 1.…”

Section: Discussionmentioning

confidence: 99%

“…We have developed a skin cleanser using sodium alkyl ether carboxylate (AEC) and alkyl carboxylates (AC), and investigated its efficacy to improve mild‐to‐moderate acne in Japanese and in Thai subjects . However, it was found that most facial cleansers, including the AEC/AC cleanser, were not able to remove the keratotic plugs well.…”

Section: Introductionmentioning

confidence: 99%

“…We have developed a skin cleanser using sodium alkyl ether carboxylate (AEC) and alkyl carboxylates (AC), 9,10 and investigated its efficacy to improve mild-to-moderate acne in Japanese and in Thai subjects. 11,12 However, it was found that most facial cleansers, including the AEC/AC cleanser, were not able to remove the keratotic plugs well. Pore strips and chemical peeling have been used to remove keratotic plugs but those treatments might be harmful to sensitive skin and are not suitable for regular use.…”

Section: Introductionmentioning

confidence: 99%

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A cleanser formulated with Tris (hydroxymethyl) aminomethane andl‐arginine significantly improves facial acne in male Thai subjects

Kumtornrut

Manabe²,

Navapongsiri³

et al. 2019

J of Cosmetic Dermatology

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Background Acne is one of the most common skin problems among human populations. A facial cleanser formulated with alkyl ether carboxylate (AEC) and alkyl carboxylate (AC) can improve acne by cleansing sebum on facial skin but cannot effectively remove keratotic plugs in the skin pores. Recently, we confirmed that Tris (hydroxymethyl) aminomethane and L‐arginine (Tris/Arg) is able to reduce sebum levels, disrupt keratotic plugs in vitro and decrease pore size on facial skin. Objective To compare the efficacy of the Tris/Arg‐formulated cleanser with the AEC/AC cleanser in Thai subjects with acne. Methods We designed a randomized, double‐blind, controlled, parallel trial. Thirty‐four male Thai subjects with mild to moderate acne were assigned to one of two groups: one group used the Tris/Arg cleanser while the other used the AEC/AC‐based cleanser twice a day for 4 weeks. Results After 4 weeks, significant decreases in noninflammatory acne were observed in both groups, yet significant decreases in inflammatory acne were only observed in the Tris/Arg cleanser group. The sebum level prior to and 30 minutes after facial washing showed no change in either group. The average pore size with keratotic plugs on the cheeks was significantly decreased in the Tris/Arg group. More than half of subjects in both groups observed acne improvement but more subjects in the Tris/Arg group noted pore size improvement. Conclusion The Tris/Arg formulated cleanser has a high efficacy for significantly reducing both noninflammatory and inflammatory acne accompanied by decreases in pore size with keratotic plugs in male Thai subjects.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 38%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A cleanser formulated with Tris (hydroxymethyl) aminomethane andl‐arginine significantly improves facial acne in male Thai subjects

Kumtornrut

Manabe²,

Navapongsiri³

et al. 2019

J of Cosmetic Dermatology

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Synthesis and properties of sodium stearyl polyoxypropylene acetates

Hu,

Zhu,

Shi

et al. 2024

J Surfact & Detergents

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Sodium stearyl polyoxypropylene acetates (SC18PpC, p = 3, 6, 9) were synthesized through a two‐step process involving propoxylation of stearyl alcohol and subsequent carboxymethylation. Stearyl polyoxypropylene acetic acids (C18PpC, p = 3, 6, 9), the acidified products of SC18PpC, were characterized by FT‐IR, 1H‐NMR, and ESI‐MS. The properties of SC18PpC were extensively investigated and compared with sodium dodecanoate (SD) and sodium stearate (SS). The solubility of SC18PpC in cold water was enhanced. Kraft temperature (Tk) of SC18P3C is 40°C which is significantly lower than SS, and Tk of SC18PpC (p = 6, 9) are even less than 0°C. SC18PpC exhibits overall greater hard water resistance compared to SD and SS with the hardness of 0 to 450 mg/L. The hard water resistance of SC18PpC escalates proportionally with the length of the spacer, and the aqueous solution of SC18P9C retains its clarity even when exposed to the hard water of 450 mg/L, the maximum hardness level of Chinese tap water. SC18PpC demonstrates efficiency and effectiveness in reducing surface tension, as well as better foaming, emulsification and wetting power compared to SD and SS. These improved properties make SC18PpC (p = 3, 6) more effective in detergency on three typical soiled fabrics compared to that of sodium soap. Specifically, the detergency to sebum‐stained fabric of SC18P3C exhibits 1.5 times and 1.3 times improvement compared to SD and SS, respectively. Therefore, it is recommended to incorporate SC18PpC (p = 3, 6) in the detergent formulations for washing intimate apparel in tap water.

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Cleansers

Reis¹,

Reis-Filho²

2017

Clinical Approaches and Procedures in Cosmetic Dermatology

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Effects of washing of the face with a mild facial cleanser formulated with sodium laureth carboxylate and alkyl carboxylates on acne in Japanese adult males

Abstract: Washing the face twice a day with facial cleanser based on AEC/soap is an effective care for moderate or less grade facial acne.

Cited by 16 publications

References 21 publications

A cleanser formulated with Tris (hydroxymethyl) aminomethane andl‐arginine significantly improves facial acne in male Thai subjects

A cleanser formulated with Tris (hydroxymethyl) aminomethane andl‐arginine significantly improves facial acne in male Thai subjects

Synthesis and properties of sodium stearyl polyoxypropylene acetates

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