Effects of Voluntary Running Exercise on Blood Pressure and Renin-Angiotensin System in Spontaneously Hypertensive Rats and Normotensive Wistar-Kyoto Rats.

Hayashi, Atsumi; Kobayashi, Ai; Takahashi, Rumiko; Suzuki, Fujio; Nakagawa, Tora; Kimoto, Katsuhiko

doi:10.3177/jnsv.46.165

Cited by 17 publications

(13 citation statements)

References 15 publications

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“…Surprisingly, ANG-(1-7) attenuated hypertension in 2K1C rats that were subjected to exercise swimming. Despite several studies (14,24,35) showing that exercise training caused a slight decrease in BP in hypertensive animals, we did not observe the similar result in trained 2K1C rats without ANG-(1-7) infusion. The differences may be due to the method of pressure measurement, type and duration of exercise, or animal models.…”

Section: Discussioncontrasting

confidence: 50%

Angiotensin-(1–7) attenuates hypertension in exercise-trained renal hypertensive rats

Shah

Lee

et al. 2012

American Journal of Physiology-Heart and Circulatory Physiology

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Shah A, Oh YB, Lee SH, Lim JM, Kim SH. Angiotensin-(1-7) attenuates hypertension in exercise-trained renal hypertensive rats. Am J Physiol Heart Circ Physiol 302: H2372-H2380, 2012. First published March 30, 2012 doi:10.1152 doi:10. /ajpheart.00846.2011 [ANG-(1-7)] plays a counterregulatory role to angiotensin II in the renin-angiotensin system. In trained spontaneous hypertensive rats, Mas expression and protein are upregulated in ventricular tissue. Therefore, we examined the role of ANG-(1-7) on cardiac hemodynamics, cardiac functions, and cardiac remodeling in trained two-kidney one-clip hypertensive (2K1C) rats. For this purpose, rats were divided into sedentary and trained groups. Each group consists of sham and 2K1C rats with and without ANG-(1-7) infusion. Swimming training was performed for 1 h/day, 5 days/wk for 4 wk following 1 wk of swimming training for acclimatization. 2K1C rats showed moderate hypertension and left ventricular hypertrophy without changing left ventricular function. Chronic infusion of ANG-(1-7) attenuated hypertension and cardiac hypertrophy only in trained 2K1C rats but not in sedentary 2K1C rats. Chronic ANG-(1-7) treatment significantly attenuated increases in myocyte diameter and cardiac fibrosis induced by hypertension in only trained 2K1C rats. The Mas receptor, ANG II type 2 receptor protein, and endothelial nitric oxide synthase phosphorylation in ventricles were upregulated in trained 2K1C rats. In conclusion, chronic infusion of ANG-(1-7) attenuates hypertension in trained 2K1C rats. swimming exercise training; atrial natriuretic peptide; cardiac hypertrophy; Mas receptor THE NEWLY DISCOVERED renin-angiotensin system (RAS) axisangiotensin-converting enzyme 2 (ACE2)/angiotensin-(1-7) [ANG-(1-7)]/Mas receptor, coined as a counteregulatory axis to ACE/ANG II/angiotensin type 1 receptor (AT 1 R), is considered as an important core factor in cardiovascular pathophysiology (8, 16). ACE2 metabolizes ANG II into ANG-(1-7), one of the major pathways for ANG-(1-7) production among others (8,11,16,19). The action of ANG-(1-7) includes vasorelaxation (46, 49), antihypertension (48, 55), antihypertrophy (25,36,52), and antifibrosis (20, 25), which are opposite to ANG II actions. At the receptor level, Mas receptor can hetero-oligomerize with AT 1 R and by so doing inhibit the actions of ANG II (31). Chronic or acute infusion of ANG-(1-7) has been shown to decrease blood pressure (BP) in spontaneously hypertensive rats (SHR; Refs. 2, 40) and high fructose diet-fed rats (20). Chronic infusion of Mas receptor antagonist or treatment with the ACE2 inhibitor worsens the course of hypertension accompanied with a decreased renal hemodynamics (5). Both Mas receptor and ACE2 knockout animals show an impaired cardiac function (22,50,55), and cardiovascular symptoms during cardiovascular pathophysiology are more aggravated in these animals (7,28,44). In contrast, ANG-(1-7) does not prevent hypertension induced by ANG II infusion (9, 21) and in two-kidney, one-clipped (2K1C) hypertension (5). Th...

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Section: Discussioncontrasting

confidence: 50%

Angiotensin-(1–7) attenuates hypertension in exercise-trained renal hypertensive rats

Shah

Lee

et al. 2012

American Journal of Physiology-Heart and Circulatory Physiology

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“…Accordingly, physical training reduced ventricular failure induced by hypertension (Moreno Júnior et al 1995), recovered ATPase activity and improved systolic function in spontaneously hypertensive rats (SHR) subjected to swimming training (Scheuer et al 1982). It has been suggested that a decreased plasma renin activity is also involved in the beneficial effects of physical training in SHR (Hayashi et al 2000;Zamo et al 2004) and in humans (Geyssant et al 1981). Furthermore, exercise training decreased plasma angiotensin (Ang) II levels in humans with chronic heart failure (Braith et al 1999).…”

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Selective increase of angiotensin(1-7) and its receptor in hearts of spontaneously hypertensive rats subjected to physical training

Filho¹,

Ferreira²,

Santos³

et al. 2008

Experimental Physiology

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In the present study we investigated the effects of physical training on plasma and cardiac angiotensin(1-7) [Ang(1-7)] levels. In addition, possible changes in expression of the Ang(1-7) Mas receptor in the heart were also evaluated. Normotensive Wistar rats and spontaneously hypertensive rats (SHR) were subjected to an 8 week period of 5% overload swimming training. Blood pressure was determined by a tail-cuff system. Heart and left ventricle weights and cardiomyocyte diameter were analysed to evaluate cardiac hypertrophy. Radioimmunoassay was used to measure angiotensin levels. Expression of Mas was determined by semi-quantitative polymerase chain reaction, immunofluorescence and Western blotting. Physical training induced cardiac hypertrophy in Wistar rats and SHR. A significant decrease of plasma angiotensin II (Ang II) levels in both strains was also observed. Strikingly, trained SHR, but not trained Wistar rats, showed a twofold increase in left ventricular Ang(1-7) levels. No significant changes were observed in plasma Ang(1-7) and left ventricular Ang II concentrations in either strain. Furthermore, Mas mRNA and protein expression in left ventricle were substantially increased in trained SHR. The physical training protocol used did not change blood pressure in either strain. These results suggest that the beneficial effects induced by swimming training in hypertensive rats might include an augmentation of Ang(1-7) and its receptor in the heart.

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“…R bras ci Saúde 9(Sup.2):3-10, 2015 4 A hipertensão arterial (HA) é uma síndrome multifatorial caracterizada pela elevação crônica dos níveis pressóricos, sendo seu desenvolvimento dependente da interação entre predisposição genética e fatores ambientais 1 . A prevalência da HA no Brasil abrange 32,5% na população adulta, chegando a 50% nos indivíduos de 60 a 69 anos de idade.…”

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“…Além disso, a HA possui baixas taxas de controle, apesar de ser considerada um dos principais fatores de risco modificáveis das doenças cardiovasculares e um dos mais importantes problemas de saúde pública 1 . A adoção de hábitos higienodietéticos adequados, tais como a redução da massa corporal, diminuição da ingestão de sódio e gorduras, diminuição ou descontinuidade do uso de álcool e tabaco, e a prática regular de exercícios físicos, compreendem inserções não medicamentosas que diminuem o risco de desenvolvimento da HA ou dão suporte ao tratamento farmacológico, promovendo uma melhora na qualidade de vida das pessoas 2 Dentre as diferentes formas de exercício físico, o exercício aeróbico, de baixa a moderada intensidade, realizado cronicamente provoca importantes adaptações autonômicas, hemodinâmicas e humorais que influenciam positivamente o sistema cardiovascular 3 , diminuindo a atividade do sistema renina angiotensina 4 , além de reduzir o tônus simpático e melhorar a sensibilidade barorreflexa 5 . Por outro lado, apesar do treinamento resistido (TR) ser reconhecido como um importante coadjuvante nos programas de prevenção, tratamento e controle da HA 2 , algumas lacunas ainda existem à cerca dos possíveis benefícios crônicos induzidos pelo TR no controle e/ ou prevenção dessa patologia.…”

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Influência do Número de Séries na Hipotensão Pós-Exercício Resistido em Indivíduos Hipertensos Sedentários

Silva¹,

Soares²,

Guedes³

et al. 2015

Rev. bras. ciênc. Saúde

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1 2 3 4 RESUMO Objetivo: Mensurar o efeito de duas sessões de treinamento resistido (TR), de igual intensidade, mas de diferentes volumes, sobre a hipotensão pós-exercício em indivíduos hipertensos sedentários. Material e Métodos: Doze indivíduos (quatro homens e oito mulheres) (54±6,74 anos) hipertensos controlados e sedentários, após duas semanas de adaptação neuromuscular nos exercícios Leg Press 45º (LP45), Remada Sentada (RS), Cadeira Extensora (CE) e Supino Horizontal (SH) e determinação da força muscular máxima nesses exercícios, foram submetidos a duas sessões aleatórias de TR. As sessões consistiam na realização de uma ou três séries, de 10 repetições, com 50% de 1-RM, aleatoriamente nos exercícios LP45, RS, CE e SH. Foi mensurada a pressão arterial sistólica (PAS), pressão arterial diastólica (PAD), frequência cardíaca (FC), duplo produto (DP), na situação de repouso, imediatamente após o último exercício (IAUE), 10, 20, 30 e 40 minutos após o término das sessões de TR. A percepção de esforço foi medida IAUE. Resultados: Os resultados mostraram IAUE que uma e três sessões de TR induziram aumentos semelhantes nos parâmetros cardiovasculares avaliados (PAS, PAD, FC e DP), entretanto, a sessão com três séries de exercícios induziu maior esforço percebido. O acompanhamento pós-exercício por 40 minutos exibiu diminuição significativa da PAS, PAD e DP em ambas as sessões de TR, sendo esta diminuição mais consistente e duradoura na sessão com três séries de exercícios. Conclusão: Podemos concluir que uma sessão de TR com três séries induziu maior hipotensão pós exercício do que uma sessão com série única, em indivíduos hipertensos sedentários. Bench Press (BP) and determination of the maximum muscle strength, underwent two random RT sessions. The sessions consisted in performing one or three sets of 10 repetitions with 50% of 1-RM, randomly in the LP45, SR, LE and BP. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), double product (DP) were measured in the rest, immediately after the last exercise (IALE), 10, 20, 30 and 40 minutes after the end of the RT sessions. The perceived exertion was measured IALE. Results: The results showed that one and three sessions of RT induced similar increases in cardiovascular parameters assessed (SBP, DBP, HR and DP) IALE, however, the session with three sets of exercises induced higher perceived exertion. The post-monitoring exercise up to 40 minutes exhibited significant decrease in SBP, DBP and DP in both RT sessions, which is more consistent and longer duration in session with three sets of exercises. Conclusion: We conclude that RT session with three sets induces a higher post-exercise hypotension effect than a single series session, in sedentary hypertensive individuals. DESCRITORES DESCRIPTORS

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Effects of Voluntary Running Exercise on Blood Pressure and Renin-Angiotensin System in Spontaneously Hypertensive Rats and Normotensive Wistar-Kyoto Rats.

Cited by 17 publications

References 15 publications

Angiotensin-(1–7) attenuates hypertension in exercise-trained renal hypertensive rats

Angiotensin-(1–7) attenuates hypertension in exercise-trained renal hypertensive rats

Selective increase of angiotensin(1-7) and its receptor in hearts of spontaneously hypertensive rats subjected to physical training

Influência do Número de Séries na Hipotensão Pós-Exercício Resistido em Indivíduos Hipertensos Sedentários

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