Effects of Volume and/or Pressure Overload Secondary to Congenital Heart Disease (Tetralogy of Fallot or Pulmonary Stenosis) on Right Ventricular Function Using Cardiovascular Magnetic Resonance and B-Type Natriuretic Peptide Levels

Oosterhof, Thomas; Tulevski, Igor I.; Vliegen, Hubert W.; Spijkerboer, Anje M.; Mulder, Barbara J.M.

doi:10.1016/j.amjcard.2005.10.047

Cited by 107 publications

(97 citation statements)

References 20 publications

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“…However, the age at TOF repair in the current study was representative for patients who underwent a surgery about 20 to 30 years earlier. [2][3][4][5]7,26,28 Neither in the current study nor in that by Davlouros et al, 2 the age at TOF repair was an independent predictor of ventricular systolic function. Broberg et al 28 showed that the age at TOF repair was not significantly different between patients with normal, mildly decreased, and moderately-to-severely decreased LV, and only patients who were 18 years old and older at the time of repair were more likely to have an impaired LV systolic function.…”

Section: Determinants Of Lvef and Rvef: Multivariate Analysiscontrasting

confidence: 45%

“…dIsCussION We demonstrated an independent association between PR severity and LVEF in a large cohort of patients after TOF repair, underscoring the impact of RV disease on LV performance. Oosterhof et al 7 showed that PRF was an independent predictor of LVEF; however, the study was conducted in a substantially smaller heterogeneous study population (n = 42) consisting mainly, but not exclusively (76%), of patients with repaired TOF. Two milestone studies by Geva et al 2 and Davlouros et al 3 revealed no association between PR severity and LVEF.…”

Section: Determinants Of Lvef and Rvef: Multivariate Analysismentioning

confidence: 99%

“…In particular, the impact of pulmonary regurgitation (PR) on LVEF and RVEF remains ambiguous. 2,3,7,8 Accordingly, the aim of the study was to assess factors associated with LVEF and RVEF in a large cohort of patients after TOF repair.…”

Section: 15mentioning

confidence: 99%

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Determinants of left- and right‑ventricular ejection fractions in patients with repaired tetralogy of Fallot: a cardiac magnetic resonance imaging study

Śpiewak¹,

Małek²,

Petryka³

et al. 2013

Polish Archives of Internal Medicine

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Section: Determinants Of Lvef and Rvef: Multivariate Analysiscontrasting

confidence: 45%

Section: Determinants Of Lvef and Rvef: Multivariate Analysismentioning

confidence: 99%

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Determinants of left- and right‑ventricular ejection fractions in patients with repaired tetralogy of Fallot: a cardiac magnetic resonance imaging study

Śpiewak¹,

Małek²,

Petryka³

et al. 2013

Polish Archives of Internal Medicine

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“…11 Geva et al 12 emphasized that LV function plays an important role in the patient's functional class. Interestingly, our study confirms a right-to-left ventricular interaction after surgery.…”

Section: Circulation July 31 2007mentioning

confidence: 99%

Preoperative Thresholds for Pulmonary Valve Replacement in Patients With Corrected Tetralogy of Fallot Using Cardiovascular Magnetic Resonance

et al. 2007

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Background-To facilitate the optimal timing of pulmonary valve replacement, we analyzed preoperative thresholds of right ventricular (RV) volumes above which no decrease or normalization of RV size takes place after surgery. Methods and Results-Between 1993 and 2006, 71 adult patients with corrected tetralogy of Fallot underwent pulmonary valve replacement in a nationwide, prospective follow-up study. Patients were evaluated with cardiovascular magnetic resonance both preoperatively and postoperatively. Changes in RV volumes were expressed as relative change from baseline. RV volumes decreased with a mean of 28%. RV ejection fraction did not change significantly after surgery (from 42Ϯ10% to 43Ϯ10%; Pϭ0.34). Concomitant RV outflow tract reduction resulted in a 25% larger decrease of RV volumes. After correction for surgical RV outflow tract reduction, higher preoperative RV volumes (mL/m 2 ) were independently associated with a larger decrease of RV volumes (RV end-diastolic volume: ␤ϭ0.41; PϽ0.001). Receiver operating characteristic analysis revealed a cutoff value of 160 mL/m 2 for normalization of RV end-diastolic volume or 82 mL/m 2 for RV end-systolic volume. Conclusions-Overall, we could not find a threshold above which RV volumes did not decrease after surgery. Preoperative RV volumes were independently associated with RV remodeling and also when corrected for a surgical reduction of the RV outflow tract. However, normalization could be achieved when preoperative RV end-diastolic volume was Ͻ160 mL/m 2 or RV end-systolic volume was Ͻ82 mL/m 2 . (Circulation. 2007;116:545-551.)

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“…[83][84][85] In pulmonary arterial hypertension, an elevated B-type natriuretic peptide level at baseline (Ͼ150 pg/mL) and follow-up (Ͼ180 pg/mL) has been associated with worse survival. 83 Elevated troponin levels have also been associated with worse outcome in pulmonary embolism and pulmonary hypertension.…”

Section: Cardiac Markersmentioning

confidence: 99%

Right Ventricular Function in Cardiovascular Disease, Part I

et al. 2008

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I n 1616, Sir William Harvey was the first to describe the importance of right ventricular (RV) function in his seminal treatise, De Motu Cordis: "Thus the right ventricle may be said to be made for the sake of transmitting blood through the lungs, not for nourishing them." 1,2 For many years that followed, emphasis in cardiology was placed on left ventricular (LV) physiology, overshadowing the study of the RV. In the first half of the 20th century, the study of RV function was limited to a small group of investigators who were intrigued by the hypothesis that human circulation could function adequately without RV contractile function. 3 Their studies, however, were based on an open pericardial dog model, which failed to take into account the complex nature of ventricular interaction. In the early 1950s through the 1970s, cardiac surgeons recognized the importance of right-sided function as they evaluated procedures to palliate right-heart hypoplasia. Since then, the importance of RV function has been recognized in heart failure, RV myocardial infarction, congenital heart disease and pulmonary hypertension. More recently, advances in echocardiography and magnetic resonance imaging have created new opportunities for the study of RV anatomy and physiology.The goal of the present review is to offer a clinical perspective on RV structure and function. In the first part, we discuss the anatomy, physiology, aging, and assessment of the RV. In the second part, we discuss the pathophysiology, clinical importance, and management of RV failure. Anatomy of the RV Macroscopic Anatomy of the RVIn the normal heart, the RV is the most anteriorly situated cardiac chamber and lies immediately behind the sternum. In the absence of transposition of great arteries, the RV is delimited by the annulus of the tricuspid valve and by the pulmonary valve. As suggested by Goor and Lillehi, 4 the RV can be described in terms of 3 components: (1) the inlet, which consists of the tricuspid valve, chordae tendineae, and papillary muscles; (2) the trabeculated apical myocardium; and (3) the infundibulum, or conus, which corresponds to the smooth myocardial outflow region 4,5 (Figure 1). In the study of congenital heart disease, this division seems to be more practical than the traditional division of the RV into sinus and conus components. 5 Additionally, the RV can also be divided into anterior, lateral, and inferior walls, as well as basal, mid, and apical sections. 6 Three prominent muscular bands are present in the RV: the parietal band, the septomarginal band, and the moderator band. The parietal band and the infundibular septum make up the crista supraventricularis. 7 The septomarginal band extends inferiorly and becomes continuous with the moderator band, which attaches to the anterior papillary muscle. 7 When abnormally formed or hypertrophied, the septomarginal band can divide the ventricle into 2 chambers (double-chambered RV). 5 Another important characteristic of the RV is the presence of a ventriculoinfundibular fold that separate...

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Effects of Volume and/or Pressure Overload Secondary to Congenital Heart Disease (Tetralogy of Fallot or Pulmonary Stenosis) on Right Ventricular Function Using Cardiovascular Magnetic Resonance and B-Type Natriuretic Peptide Levels

Cited by 107 publications

References 20 publications

Determinants of left- and right‑ventricular ejection fractions in patients with repaired tetralogy of Fallot: a cardiac magnetic resonance imaging study

Determinants of left- and right‑ventricular ejection fractions in patients with repaired tetralogy of Fallot: a cardiac magnetic resonance imaging study

Preoperative Thresholds for Pulmonary Valve Replacement in Patients With Corrected Tetralogy of Fallot Using Cardiovascular Magnetic Resonance

Right Ventricular Function in Cardiovascular Disease, Part I

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