Effects of Voglibose on Glycemic Excursions, Insulin Secretion, and Insulin Sensitivity in Non-lnsulin-ireated NIDDM Patients

Matsumoto, Kazunari; Yano, Mototake; Miyake, Seibei; Ueki, Yukitaka; Yamaguchi, Yoshihiko; Akazawa, Shoichi; Tominaga, Yuko

doi:10.2337/diacare.21.2.256

Cited by 83 publications

(39 citation statements)

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“…When glycemic control is good, 1,5-AG levels rise, 8,20 and when glycemic control is poor, 1,5-AG levels fall. 21 Serum 1,5-AG levels were measured with an enzymatic method using 1,5-AG Auto Liquid reagent (Nippon Kayaku Co., Ltd, Tokyo) and an automatic clinical analyzer (model 7150; Hitachi, Tokyo).…”

Section: Classification Of Postprandial Glycemic Controlmentioning

confidence: 96%

“…4 An automated assay for serum 1,5-anhydroglucitol (1,5-AG), as a new biochemical marker, has been first used in Japan since 1991, and a similar assay (GlycoMark 1,5-AG test; GlycoMark, Inc., New York, NY) has been approved in the United States. 5,6 The serum 1,5-AG level has been shown to generally reflect postprandial hyperglycemia 7 but not fasting hyperglycemia 8 and to be strongly and negatively correlated with the plasma glucose level at 120 min of the oral glucose tolerance test in subjects with IGT. 7 Postprandial glycemic levels have been difficult to monitor, but 1,5-AG levels have proven to be beneficial for this purpose.…”

Section: Introductionmentioning

confidence: 99%

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Postprandial Glycemic Control Conditions in Relation to UrinaryN-Acetyl-β-d-Glucosaminidase in Patients with Type 2 Diabetes Mellitus Without Low Glomerular Filtration Rate

Ouchi

Oba

Motoyama

et al. 2014

Diabetes Technology & Therapeutics

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Section: Classification Of Postprandial Glycemic Controlmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Postprandial Glycemic Control Conditions in Relation to UrinaryN-Acetyl-β-d-Glucosaminidase in Patients with Type 2 Diabetes Mellitus Without Low Glomerular Filtration Rate

Ouchi

Oba

Motoyama

et al. 2014

Diabetes Technology & Therapeutics

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show abstract

“…Developed in Japan as a new marker for glycaemia [7][8][9][10][11][12][13][14], the measurement of 1,5-anhydroglucitol (1,5-AG) in serum can detect slight changes in the glycaemic state, and therefore appears well suited to monitoring glucose homoeostasis in patients with near-normoglycaemia [13,15,16] or postprandial hyperglycaemia [13,17,18]. Within its epidemiologically defined normal range, 1,5-AG has an individual normal value for each patient, and falls rapidly from this norm (by as much as hundreds of milligrams of glucose per day) if it is being excreted continuously in the urine [19].…”

Section: Introductionmentioning

confidence: 99%

Post-load glucose measurements in oral glucose tolerance tests correlate well with 1,5-anhydroglucitol, an indicator of overall glycaemic state, in subjects with impaired glucose tolerance

Yamanouchi¹,

INOUE²,

OGATA³

et al. 2001

Clinical Science

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Using both cross-sectional and longitudinal methods, we investigated the relationship between post-load serum glucose concentration in a 75 g oral glucose tolerance test (OGTT) and overall glycaemic state in subjects with impaired glucose tolerance (IGT). Glycaemic state was assessed by measuring glycated haemoglobin (HbA1c) and the serum concentration of 1,5-anhydroglucitol (1,5-AG). In the cross-sectional study, the concentration of 1,5-AG, while remaining within a normal range, was reduced to a degree proportional to the post-load glycaemic level. Although the correlation between HbA1c and post-load plasma glucose was relatively weak (r=0.281, P<0.001), a significant inverse correlation (r=-0.824, P<0.0001) was found between 1,5-AG and mean post-load plasma glucose concentration in 211 subjects with IGT. Fasting plasma glucose (r=-0.539, P<0.0001) and 2 h plasma glucose (r=-0.621, P<0.0001) were correlated with 1,5-AG less strongly than was post-load glycaemia. Both 1,5-AG and HbA1c were correlated weakly but significantly with the fasting insulin concentration. In the longitudinal study we measured 1,5-AG and mean post-load plasma glucose with an OGTT once yearly for 10 years in 15 subjects with IGT. Strong inverse correlations were seen between 1,5-AG and mean post-load plasma glucose in each subject (range of r values among subjects of -0.584 to -0.978). These findings suggest a close relationship between post-load plasma glucose concentration measured by OGTT and overall glycaemic state in subjects with IGT.

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“…In addition, validamycin can be used as the source for chemical synthesis of voglibos, an important antidiabetic drug (Matsumoto et al, 1998). Considerable efforts have been devoted to understand the validamycin biosynthesis and fermentation regulation.…”

Section: Introductionmentioning

confidence: 99%

Engineering validamycin production by tandem deletion of γ-butyrolactone receptor genes in Streptomyces hygroscopicus 5008

Tan

Peng

et al. 2015

Metabolic Engineering

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Paired homologs of γ-butyrolactone (GBL) biosynthesis gene afsA and GBL receptor gene arpA are located at different positions in genome of Streptomyces hygroscopicus 5008. Inactivation of afsA homologs dramatically decreased biosynthesis of validamycin, an important anti-fungal antibiotic and a critical substrate for antidiabetic drug synthesis, and the deletion of arpA homologs increased validamycin production by 26% (ΔshbR1) and 20% (ΔshbR3). By double deletion, the ΔshbR1/R3 mutant showed higher transcriptional levels of adpA-H (the S. hygroscopicus ortholog of the global regulatory gene adpA) and validamycin biosynthetic genes, and validamycin production increased by 55%. Furthermore, by engineering a high-producing industrial strain via tandem deletion of GBL receptor genes, validamycin production and productivity were enhanced from 19 to 24 g/L (by 26%) and from 6.7 to 9.7 g/L(-1) d(-1) (by 45%), respectively, which was the highest ever reported. The strategy demonstrated here may be useful to engineering other Streptomyces spp. with multiple pairs of afsA-arpA homologs.

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Effects of Voglibose on Glycemic Excursions, Insulin Secretion, and Insulin Sensitivity in Non-lnsulin-ireated NIDDM Patients

Abstract: The results suggest that voglibose lowers the daily glycemic excursions and inhibits overwork of the pancreatic beta-cells but has little effect on insulin sensitivity in NIDDM patients.

Cited by 83 publications

References 0 publications

Postprandial Glycemic Control Conditions in Relation to UrinaryN-Acetyl-β-d-Glucosaminidase in Patients with Type 2 Diabetes Mellitus Without Low Glomerular Filtration Rate

Postprandial Glycemic Control Conditions in Relation to UrinaryN-Acetyl-β-d-Glucosaminidase in Patients with Type 2 Diabetes Mellitus Without Low Glomerular Filtration Rate

Post-load glucose measurements in oral glucose tolerance tests correlate well with 1,5-anhydroglucitol, an indicator of overall glycaemic state, in subjects with impaired glucose tolerance

Engineering validamycin production by tandem deletion of γ-butyrolactone receptor genes in Streptomyces hygroscopicus 5008

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