Effects of Vitamin Treatment or Supplements with Purported Antioxidant Properties on Skin Cancer Prevention: A Meta-Analysis of Randomized Controlled Trials

Chang, Yoon Jung; Myung, Seung‐Kwon; Chung, Sung Tae; Kim, Yeol; Lee, Eun‐Hyun; Jeon, Young-Jee; Park, Chang-Hae; Seo, Hong Gwan; Huh, Bong Yul

doi:10.1159/000329439

Cited by 20 publications

(13 citation statements)

References 75 publications

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“…70,71 Despite the positive cardiovascular effects of Omega-3 fatty acids, a major systemic review did not find a reduction in the risk of cancer. 72 …”

Section: Modifiable Cvd Risk Factors and Their Cancer Riskmentioning

confidence: 99%

Shared Risk Factors in Cardiovascular Disease and Cancer

et al. 2016

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Cardiovascular disease (CVD) and cancer are the two leading causes of death worldwide. Although commonly thought of as two separate disease entities, CVD and cancer possess various similarities and possible interactions, including a number of similar risk factors (e.g. obesity, diabetes), suggesting a shared biology for which there is emerging evidence. While chronic inflammation is an indispensible feature of the pathogenesis and progression of both CVD and cancer, additional mechanisms can be found at their intersection. Therapeutic advances, despite improving longevity, have increased the overlap between these diseases, but there are now millions of cancer survivors at risk of developing CVD. Cardiac risk factors have a major impact on subsequent treatment-related cardiotoxicity. In this review, we explore the risk factors common to both CVD and cancer, highlighting the major epidemiologic studies and potential biological mechanisms that account for them.

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“…70,71 Despite the positive cardiovascular effects of Omega-3 fatty acids, a major systemic review did not find a reduction in the risk of cancer. 72 …”

Section: Modifiable Cvd Risk Factors and Their Cancer Riskmentioning

confidence: 99%

Shared Risk Factors in Cardiovascular Disease and Cancer

et al. 2016

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“…Other clinical trials also indicated that Vitamin E intake increased the risk of prostate cancer, and Se supplementation intake could increase the prostate cancer risk in men with preexisting high levels of Se [50]. For the long term intake, clinical trials also showed that Vitamins such as Vitamin A, C, E and β-carotene exert no significant beneficial effects in skin cancer prevention [66,67]. Other antioxidants, such as α-tocopherol, do not contribute to the prevention of lung cancer.…”

Section: No Significant Advantage Of Antioxidants Observed In Clinicamentioning

confidence: 99%

Reactive oxygen species in redox cancer therapy

et al. 2015

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“…Studies of these four supplements in humans have not supported their role in skin cancer prevention. Randomized controlled trials (RCT) of beta-carotene, selenium, and combination supplements (including various combinations of vitamin C, vitamin E, beta-carotene, selenium, and other substances) have not been shown to reduce the incidence of NMSC in men or women [ 35 – 41 ]. Details of these studies are provided in Table 1 .…”

Section: Human Subject Studies: Antioxidant Supplementsmentioning

confidence: 99%

“…A related conclusion was drawn by Chang et al While their meta-analysis of 10 large RCTs with vitamins and supplements known to have AO properties showed no reduction of NMSC incidence, the researchers did draw a distinction between supplements and whole foods [ 41 ]. They stated that when consumed in a fruit or vegetable, these AOs are consumed in relative quantities with one another that may be vital to their AO qualities.…”

Section: The Biochemical Process Of Antioxidation: a Proposed Explmentioning

confidence: 99%

Diet and Skin Cancer: The Potential Role of Dietary Antioxidants in Nonmelanoma Skin Cancer Prevention

Katta

Brown

2015

Journal of Skin Cancer

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Nonmelanoma skin cancer (NMSC) is the most common cancer among Americans. Ultraviolet (UV) radiation exposure is the major risk factor for the development of NMSC. Dietary AOs may prevent free radical-mediated DNA damage and tumorigenesis secondary to UV radiation. Numerous laboratory studies have found that certain dietary AOs show significant promise in skin cancer prevention. These results have been substantiated by animal studies. In human studies, researchers have evaluated both oral AO supplements and dietary intake of AOs via whole foods. In this review, we provide an overview of the role of AOs in preventing tumorigenesis and outline four targeted dietary AOs. We review the results of research evaluating oral AOs supplements as compared to dietary AOs intake via whole foods. While these specific supplements have not shown efficacy, intake of AOs via consumption of whole foods has shown some promise. Lessons learned from the field of hypertension research may provide important guidance in future study design. Further research on the role of dietary AOs in the prevention of NMSC is warranted and should focus on intake via whole food consumption.

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Effects of Vitamin Treatment or Supplements with Purported Antioxidant Properties on Skin Cancer Prevention: A Meta-Analysis of Randomized Controlled Trials

Cited by 20 publications

References 75 publications

Shared Risk Factors in Cardiovascular Disease and Cancer

Shared Risk Factors in Cardiovascular Disease and Cancer

Reactive oxygen species in redox cancer therapy

Diet and Skin Cancer: The Potential Role of Dietary Antioxidants in Nonmelanoma Skin Cancer Prevention

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