Effects of vitamin E supplementation on the clinical outcome of dengue fever and dengue haemorrhagic fever in children

Carnosine exhibits significant antiviral activity against Dengue and Zika virus

“…A clinical trial assessing the effects of seven antioxidative compounds in chronic hepatitis C patients showed normalization of liver injury marker and histologic improvement in the patients . Similarly, supplementation with antioxidant vitamin E improved clinical, hematological, and biochemical parameters in children with dengue fever and dengue hemorrhagic fever . In addition to its antioxidant activity, carnosine also demonstrate anti‐inflammatory property where it could directly interact with nitric oxide and protect cells against peroxynitrite‐induced damage during influenza A (H1N1) pathogenesis .…”

Management of dengue infection: improving morbidity

“…A randomized controlled study done in Sri Lanka among children has shown that duration of leaking is significantly reduced by vitamin E supplementation (33.5 hours vs 44.8 hours; p=0.023) [40]. In vitamin E supplemented group serum albumin was higher, haematocrit, was lower suggesting that there was less leakage [40].…”

Micronutrient Supplementation and Clinical Outcomes in Patients with Dengue Fever

“…Protection of cell membranes from oxidative damage, scavenging of peroxyl radicals, enhancement of immune function via enzyme activation and changes in gene expression 21…”

“…11,12 Providers caring for DF patients sometimes provide micronutrient supplements as an adjunct to standard supportive care, [13][14][15] as these supplements are generally inexpensive and some may offer hypothetical benefits to dengue patients via numerous potential mechanisms, including modulation of the host immune response [16][17][18][19][20] and antioxidant effects. 13,21 Proposed mechanisms of clinical benefit in DF for several micronutrients are outlined in Table 1.…”

“…Several recent studies have sought to evaluate the efficacy of micronutrient supplementation among DF patients. These studies have investigated associations between clinical outcomes and supplementation of various micronutrients, including vitamin C, 13,22 vitamin D, 23 vitamin E, 21,24 folic acid, 14 and zinc. 25 No prior literature review has summarized the findings of these clinical studies.…”