Effects of vitamin E on cholesterol levels of hypercholesterolemic patients receiving statins

Abstract

Vitamin E supplementation did not affect total or low-density-lipoprotein cholesterol levels in hypercholesterolemic patients receiving lovastatin or simvastatin. A small but significant decrease in HDL cholesterol levels was observed in the group that received vitamin E supplementation during the supplementation period, but this decrease was no longer significantly different from the placebo group's levels two weeks postsupplementation. The decrease in HDL cholesterol levels did not appear to be related to either CYP3A or CETP.

Effect of conjugated linoleic acid, vitamin E and their combination on lipid profiles and blood pressure of Iranian adults with active rheumatoid arthritis

“…Similar to our study they didn’t find significant differences in any lipoprotein cholesterol fraction. However, unlike our study, a 6% decrease in HDL-C was detected within the vitamin E group (p < 0.05) (Leonard et al 2007). Following our study, LDL-C increased in all groups, but this increase was only significant in group E. This increase may be due to increasing the size of LDL-C or changing its fractions or by increase of its half life by decreasing LDL-C oxidation.…”

“…In the present study, the number of platelet decreased nonsignificantly in groups P, C, and CE. Leonard and colleagues (2007) studied the effects of vitamin E (400 IU) on cholesterol levels of hypercholesterolemic patients receiving statins. Similar to our study they didn’t find significant differences in any lipoprotein cholesterol fraction.…”

Vitamin E decreases endogenous cholesterol synthesis and apo-AI-mediated cholesterol secretion in Caco-2 cells

“…5). Such mechanism could explain the inhibitory effect of tocopherols on blood HDL-cholesterol previously observed in human studies [45][46][47]. Moreover, in physiopathological state, such as insulin resistance and diabetes, where the intestinal cholesterol synthesis is increased [48], the effect of tocopherols could limit, at least in part, cholesterol overproduction.…”

α-Tocopherol injections in rats up-regulate hepatic ABC transporters, but not cytochrome P450 enzymes

“…Three studies to test this hypothesis in humans have not demonstrated decreased drug efficacy. When Leonard et al [45] gave vitamin E supplements to hypercholesterolemic patients, the supplements did not alter efficacy of either simvastatin or lovastatin, two drugs metabolized via a CYP3A-dependent mechanism. Werba et al [46] approached this problem by studying the effect of simvastatin (20 mg/day) or pravastatin 40 (mg/day) on α- and γ-tocopherol concentrations in hypercholesterolemic humans.…”