Effects of Vitamin E, C and D Supplementation on Inflammation and Oxidative Stress in Streptozotocin-Induced Diabetic Mice

Greń, Agnieszka

doi:10.1024/0300-9831/a000156

Cited by 32 publications

(19 citation statements)

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“…A decline in serum testosterone and HDL and an increase in serum cholesterol, triglyceride, LDL and VLDL were also observed in these animals. These observed alterations are in accordance with some earlier reports, made on the oxidative impairments in the male reproductive system of diabetic subjects [6,7,14,46].…”

Section: Resultssupporting

confidence: 82%

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Effects of Pyrroloquinoline Quinone and Vitamin C on Diabetes Associated Testicular Dysfunction and Oxidative Damages in Testis of Streptozotocin-Induced Diabetic Mice: Histopathological Study

Kumar¹,

Kar²

2017

SOJPPS

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The aim of this study was to investigate the hitherto unknown potential of Pyrroloquinoline Quinone (PQQ) in regulating diabetes associated testicular dysfunctions and oxidative damages in testis of adult mice. Seven groups such as normoglycemic and PQQ treated controls; STZ-treated and STZ + PQQ treated (5, 10 and 20 mg/ kg/day, separately) and STZ + Vit.C (50 mg/kg) were established. After 18 days of experimentation, alterations in the markers of oxidative stress, various antioxidants, lipid profile, serum insulin, testosterone and testicular histology were evaluated. Administration of single dose of STZ (150 mg/kg b.wt) enhanced not only testicular lipid peroxidation and lipid hydroperoxides levels; but also serum concentration of glucose, cholesterol, triglyceride, low density lipid and very low density lipid; with a parallel decrease in serum insulin, testosterone, and different antioxidants in diabetic mice. However, on simultaneous administration of PQQ, particularly at a dose of 20 mg/kg, most of these adverse effects were ameliorated. While the PQQ (20 mg/kg) decreased the serum glucose by 50%, it increased insulin and testosterone levels by 59% and 169% respectively in STZinduced animals, these results suggest that PQQ may have potential to ameliorates diabetes-induced testicular dysfunction.

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Section: Resultssupporting

confidence: 82%

“…These observations led us to assume that a potent antioxidant is crucial in reducing the damage caused by oxidative stress. Some experimental, epidemiological and clinical studies also emphasize that antioxidants might be helpful for treating diabetes and its complication [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Effects of Pyrroloquinoline Quinone and Vitamin C on Diabetes Associated Testicular Dysfunction and Oxidative Damages in Testis of Streptozotocin-Induced Diabetic Mice: Histopathological Study

Kumar¹,

Kar²

2017

SOJPPS

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“…The decrease in concentration of Vitamin C, Vitamin E, GSH and increase in concentration of TBARS is observed in diabetic mice when compared with control which is in accordance with previous reports indicating depletion in Vitamin C, Vitamin E, GSH content is due to higher level of free radicals generation [22,26,27]. The decrease in activity of enzymes SOD and catalase and increase in activity of GGT was observed in diabetic mice might be due to insulin insufficiency in Type 1 diabetes which results in increased hydrogen peroxide production due to increase in oxidation [28].…”

Section: Discussionsupporting

confidence: 80%

Evaluation of Antioxidant Potential of Clarias Batrachus Oil in Alloxan Induced Diabetic Mice (Mus Musculus)

Kamat¹

2015

J Diabetes Metab

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Introduction: Diabetes mellitus is a chronic disorder in human and responsible for different complications and also causes mortality and morbidity. Long chain fatty acids influence inflammation through a variety of mechanisms; many of these are mediated by, or at least associated with, changes in fatty acid composition of cell membranes. Hence the present study was performed to investigate the effect of fish oil extracted from Clarias batrachus which is a good source of PUFA n-3 among freshwater species on alloxan-induced diabetic mice. Material and method:Alloxan was administered at repetitive doses (100 mg/kg b.wt after every 5 th day for a period of one month to induce diabetes in mice. Along with alloxan injection, 10% Clarias fish oil was supplemented to diabetic mice for a period of one month. Analysis of basic antioxidant and lipid peroxidation parameters in serum, liver, kidney, heart and pancreatic tissues was carried out. Result:The levels of antioxidant and lipid peroxidation markers were significantly (P<0.05) altered in all the tissues of alloxan-induced diabetic mice. The supplementation of fish oil to diabetic mice showed significant recovery in activity of enzymes SOD, Catalase and in concentration of Vitamin C which is decreased in diabetic control mice. Conclusion:The result of this study indicated fish oil supplementation in diabetic mice helped to reduce the elevated glucose and glycosylated haemoglobin level along with an increase in insulin concentration and helped to recover the altered antioxidant and enzyme activity, which specifies that long term treatment of diabetes with fish oil may help to reduce the diabetes induced tissue damages.

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“…Melatoninle birlikte C ve E vitamini verilen diyabetik ratlarda plazma glukoz ve MDA düzeyleri azalmış, hematolojik ve biyokimyasal parametrelerle antioksidan düzeylerinin normale döndüğü görülmüştür (55). Fareler üzerinde yapılan bir başka çalışmada da streptozotosinle diyabet oluşturulduktan sonra C, E ve D vitamini verildiğinde oksidatif stres ve enflamasyona karşı koruyucu etki görülmüştür (56). Kısa süreli deneysel bir çalışmada da yüksek dozda C vitamininin diyabetteki endotel bozuklukları iyileştirebileceği gösterilmiştir (57 Coleman ve ark.…”

Section: Deneysel çAlışmalarunclassified

The Role of Oxidative Stress and Antioxidants in Diabetes Mellitus

Hamamcıoğlu¹

2017

Turk J Diab Obes

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ÖZETDiyabete bağlı komplikasyonlarının oluşmasında oksidatif stres önemli role sahiptir. Diyabetli hastalarda mevcut hiperglisemi serbest radikal oluşumunu artırır; endojen antioksidanlar toksik reaktif oksijen türlerini dengelemek için yeterli olmaz ve buna bağlı olarak oksidatif streste artış meydana gelir. Antioksidan savunma mekanizmaları hem enzimatik hem de enzimatik olmayan yolaklar içerir. Başlıca antioksidanlar A, C ve E vitaminleri, glutatyon ve enzimatik olarak da süperoksit dismutaz, katalaz, glutatyon peroksidaz ve glutatyon redüktazdır. Burada diyabette oksidatif stresin yanısıra antioksidan savunma mekanizmalarının öneminden ve invivo olarak olası terapötik etkilerinden sözedilecektir. ABSTRACTOxidative stress has a crucial role in the development of diabetic complications. Hyperglycemia in diabetic patients enhances free radical formation. This causes an insufficient amount of endogenous antioxidants to balance toxic reactive species which then results high amount of oxidative stress. Antioxidant defense mechanisms may have both enzymatic and non enzymatic pathways. Non-enzymatic antioxidants are Vitamin A, C, E and glutathione and the enzymatic antioxidants are superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase. This review will discuss the oxidative stress as well as the importance of antioxidants in diabetes mellitus. The Role of Oxidative Stress and Antioxidants in Diabetes Mellitus GİRİŞDiyabet dünyada en fazla hasar ve ölüme neden olan hastalıktır. Uluslararası Diyabet Federasyonuna göre 2014 te 20-79 yaş arasındaki yetişkinlerin % 8,2'si (387 milyon kişi) diyabet hastasıdır ve bu sayının 2035 te 592 milyonu geçmesi beklenmektedir (1). Açlık kan şekerinin yükselmesi (>126 mg/dl, HbA1c>% 6,5 mg) diyabet varlığını gösterir. İnsülin üretimi ya da fonksiyonlarında hasar oluşması sonucunda karbonhidrat, lipid ve protein metabolizması fonksiyonlarının yetersiz kalması ile uzun süreli sağlık sorunlarının ortaya çıkması sonucunda diabetes mellitus oluşur (2). Diyabet hastalarında hipergliseminin kontrol edilememesi sonucunda gözlerde diyabetik retinopati, böbreklerde diyabetik nefropati, sinirlerde diyabetik nöropati, kalpte miyokardiyal enfarktüs ve damarlarda ateroskleroz oluşabilmektedir (3). Reaktif Oksijen TürleriYaşamın sürdürülmesi için moleküler oksijen gereklidir. Vücut tarafından tüketilen oksijenin % 1-3 ü ROT (Reaktif Oksijen Türleri) ne dönüşür. ROT oluşumu toksik olabilir (4). İnsanlar pek çok karsinojene maruz kalsa da en belirgin olanları oksijen ve nitrojen kaynaklı ROT ve RNT (Reaktif Nitrojen Türleri) olarak bilinen reaktif türlerdir. İnsan vücudunda ROT ve RNT oluşumu çeşitli makromoleküllerde özellikle de plazma membranında oksidatif hasar oluşturur. Bunun sonucunda da kanser, koroner vasküler hastalık, diyabet gibi oksidatif stres aracılı fonksiyon bozuklukları ortaya çıkar (5).

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Effects of Vitamin E, C and D Supplementation on Inflammation and Oxidative Stress in Streptozotocin-Induced Diabetic Mice

Abstract: These results indicate the preventive role of vitamin C, E, and D against STZ-induced diabetic oxidative stress and inflammation. Hence these vitamins could be used as an adjuvant therapy for the prevention and/or management of diabetes.

Cited by 32 publications

References 0 publications

Effects of Pyrroloquinoline Quinone and Vitamin C on Diabetes Associated Testicular Dysfunction and Oxidative Damages in Testis of Streptozotocin-Induced Diabetic Mice: Histopathological Study

Effects of Pyrroloquinoline Quinone and Vitamin C on Diabetes Associated Testicular Dysfunction and Oxidative Damages in Testis of Streptozotocin-Induced Diabetic Mice: Histopathological Study

Evaluation of Antioxidant Potential of Clarias Batrachus Oil in Alloxan Induced Diabetic Mice (Mus Musculus)

The Role of Oxidative Stress and Antioxidants in Diabetes Mellitus

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