Effects of vitamin E and vitamin C on male infertility: a meta-analysis

Zhou, Xianling; H, Shi; Zhu, Shiping; Wang, Haixia; Sun, Shengyun

doi:10.1007/s11255-022-03237-x

Cited by 12 publications

(14 citation statements)

References 44 publications

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“…For instance, vitamin E (alpha-tocopherol) is a fat-soluble molecule found in spinach, avocados, sweet potatoes and almonds. Many previous reports clarified its powerful antioxidant activities by neutralizing free radicals and constraining ROS destruction to cell membranes, resulting in the avoidance of lipid peroxidation and augmentation of another antioxidative system [ 21 , 22 ].…”

Section: Dietary Nutrientsmentioning

confidence: 99%

“…Reports from the European Commission Directive 2008/100/EC have endorsed the daily consumption of 12 mg vitamin E [ 22 ]. The association between the decline of vitamin E consumption per day and fertility outcomes has been drawn in animals [ 32 ].…”

Section: Dietary Nutrientsmentioning

confidence: 99%

“…An abundance of previous reports have assessed the impacts of vitamin C (vit. C) supplementation on sperm function [ 22 ]. An earlier study by Lewis and Simon [ 60 ] demonstrated that male rats given vit.…”

Section: Dietary Nutrientsmentioning

confidence: 99%

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The Role of Dietary Nutrients in Male Infertility: A Review

Almujaydil

2023

Life

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Male infertility is the main health issue with economic, psychological, and medical attributions. Moreover, it is characterized by an inability to produce a sufficient amount of sperm for the fertilization of an oocyte. Dietary nutrients (DN) have a great effect on male reproductive potential. Observations have indicated that adding DN may protect or treat male infertility. The scope of this criticism is to scrutinize the DN, such as omega-3 fatty acids, vitamins, minerals and other phytochemicals, in enhancing the semen attributes, sperm bioenergetics and sperm functionality in male infertility. It seems that diets rich in omega-3 fatty acids affect sperm quality and maintain the sperm membrane and mitochondria stability. An administration of phytochemicals caused an escalation in sperm mitochondrial function and a decrease in oxidative damage. Furthermore, sundry dietary natural phytochemicals differentially affect (negatively or positively) sperm motility, semen quality, and mitochondrial function, dependent on their levels. Vitamins and trace elements are also nutritional modulators in reducing oxidative stress, thereby enhancing sperm quality, which is accurately connected with sperm mitochondrial function. Also, we described the different types of DN as mitochondrial enhancer for sperm functionality and health. We believe that understanding the DN supports sperm mitochondria and epigenetic modulators that may be responsible for sperm quality and health, and will lead to more embattled and efficient therapeutics for male infertility.

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Section: Dietary Nutrientsmentioning

confidence: 99%

Section: Dietary Nutrientsmentioning

confidence: 99%

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The Role of Dietary Nutrients in Male Infertility: A Review

Almujaydil

2023

Life

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“…Higher concentrations of AA have been found in the seminal plasma of fertile men, leading to the assumption that it plays an important role as a seminal antioxidant [ 24 , 25 ]. Some studies noted an increase in semen parameters such as motility, concentration, morphology and DNA integrity, as well as higher pregnancy rates, after AA antioxidant therapy [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

“…Whereas it is well known that many antioxidants can enhance their protective action if they act in synergy, [ 26 , 46 , 47 , 48 ] the aim of this work was to test the potential antigenotoxic of AA and EA in combination on human spermatozoa in vitro. For this purpose, human sperm cells were treated in vitro with associated AA, plus EA and benzene as oxidizing agents, for different lengths of exposure (45, 60 and 90 min).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Combination of Ascorbic and Ellagic Acids in Sperm Oxidative Damage Inhibition

Mottola

Iovine²,

Carrannante

et al. 2022

IJMS

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It is known that an altered redox balance interferes with normal spermatic functions. Exposure to genotoxic substances capable of producing oxidative stress (OS) can cause infertility in humans. The use of antioxidants to reduce oxidative stress contributes to the improvement in reproductive function. This study focused on an antigenotoxic evaluation of ellagic acid (EA) and ascorbic acid (AA) in combination against benzene genotoxic action on human spermatozoa in vitro. In addition to the evaluation of sperm parameters, damage in sperm genetic material and intracellular ROS quantification were assessed after AA, EA and benzene co-exposure using the TUNEL technique and DCF assay. The results showed that the combination of the two antioxidants generates a greater time-dependent antigenotoxic action, reducing both the sperm DNA fragmentation index and the oxidative stress. The genoprotective effect of AA and EA association in sperm cells lays the foundations for a more in-depth clinical study on the use of antioxidants as a therapy for male infertility.

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Utility of vitamin C in ameliorating citalopram‐induced testicular toxicity via modulating nitro‐oxidative stress and apoptosis in mice

Moradi,

Hashemian,

Fathi

et al. 2023

J Biochem & Molecular Tox

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There is a growing concern that antidepressant drugs impair sexual function and adversely impact spermatogenesis and male fertility. Vitamin C is a natural antioxidant that plays a vital role in the male reproductive system. The present study investigated the ameliorating potential of vitamin C against citalopram (CTL)‐evoked testicular toxicity and spermatogenesis impairment in mice. Mice were randomly divided into six groups: control, CTL, vitamin C 100, vitamin C 200, CTL plus vitamin C 100, and CTL plus vitamin C 200. Adult male mice were intraperitoneally (ip) injected with 10 mg/kg of CTL for 35 days with or without vitamin C. At the end of the study, body and testes weight, sperm parameters, histopathology of testes, testosterone level, testicular levels of malondialdehyde (MDA), nitric oxide (NO), total antioxidant capacity (TAC), and apoptosis (TUNEL assay) were evaluated. Our findings revealed that vitamin C restored spermatogenesis by improving sperm count, motility, viability, morphology, and chromatin integrity. Testosterone levels and testes histopathology were significantly improved in the vitamin C‐administrated groups. Furthermore, vitamin C administration markedly alleviated CTL‐induced nitro‐oxidative damage, enhancing TAC levels, and reducing NO and MDA levels. Whilst CTL therapy induced a significant increase in the number of TUNEL‐positive cells compared to the control, the administration of vitamin C significantly prevented the apoptotic effects of CTL. Together, vitamin C therapy protects against CTL‐induced testicular damage via mitigating nitro‐oxidative stress and apoptosis, which provides evidence for vitamin C as a beneficial therapy against antidepressant drug‐associated reproductive toxicity and male sub/infertility.

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Effects of vitamin E and vitamin C on male infertility: a meta-analysis

Cited by 12 publications

References 44 publications

The Role of Dietary Nutrients in Male Infertility: A Review

The Role of Dietary Nutrients in Male Infertility: A Review

In Vitro Combination of Ascorbic and Ellagic Acids in Sperm Oxidative Damage Inhibition

Utility of vitamin C in ameliorating citalopram‐induced testicular toxicity via modulating nitro‐oxidative stress and apoptosis in mice

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