Effects of vitamin D supplementation on metabolic and endocrine parameters in PCOS: a randomized-controlled trial

Trummer, Christian; Schwetz, Verena; Kollmann, Markus; Wölfler, M; Münzker, Julia; Pieber, Thomas R.; Pilz, Stefan; Heijboer, Annemieke C.; Obermayer–Pietsch, Barbara; Lerchbaum, Elisabeth

doi:10.1007/s00394-018-1760-8

Cited by 53 publications

(66 citation statements)

References 38 publications

(41 reference statements)

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“…Participants were randomly allocated to the intervention or placebo (PBO) groups of the vitamin D RCTs. Methods and study design have been published in detail previously [25][26][27][28][29]. Briefly, study participants received 20,000 IU of cholecalciferol weekly equaling 50 oily drops per week or 7 oily drops per day (Oleovit D3© drops; Fresenius Kabi Austria) for 8 or 12 weeks, respectively.…”

Section: Study Populationsmentioning

confidence: 99%

“…This trial was designed to investigate the effects of vitamin D supplementation on metabolic and endocrine parameters in women with polycystic ovary syndrome (PCOS, n = 180) according to the Rotterdam criteria [25] and in healthy premenopausal women (n = 150) [26]. To investigate short-time effects of vitamin D supplementation, a follow-up visit 12 weeks after inclusion into the study was scheduled.…”

Section: "Rct1" Vitamin D and Metabolic And Endocrine Parameters In mentioning

confidence: 99%

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Genetic Components of 25-Hydroxyvitamin D Increase in Three Randomized Controlled Trials

Trummer

Schweighofer

Haudum

et al. 2020

JCM

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The 25-Hydroxyvitamin D (25[OH)D) serum concentration depends on vitamin D intake, endogenous vitamin D production and genetic factors. The latter have been demonstrated in large genome-wide association studies indicating that single nucleotide polymorphisms (SNPs) in genes related to the vitamin D metabolism are as important for serum 25(OH)D levels as the influence of season. The mechanism on how these SNPs influence serum 25(OH)D levels are still unclear. The aim of the present study was to investigate the genetic effects of ten selected SNPs related to vitamin D metabolism on 25-hydroxyvitamin D increase (∆25(OH)D) after vitamin D supplementation in three randomized controlled trials. Genotypes of SNPs related to vitamin D metabolism were determined in 411 participants with 25(OH)D concentrations < 75 nmol/l receiving 20,000 IU cholecalciferol per week for 8 or 12 weeks after study inclusion. For the vitamin D receptor (VDR) rs10783219 polymorphism, the minor A-allele was associated with lower ∆25(OH)D values in the entire study population (p = 0.022), which was not consistent in all three cohorts when analysed separately. VDR rs10783219 might therefore be a genetic modulator of increasing 25-hydroxyvitamin D concentrations. Considering the wide-spread use of vitamin D supplementation, future large and well-designed randomized controlled trials (RCTs) should investigate the clinical impact of this polymorphism.

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Section: Study Populationsmentioning

confidence: 99%

Section: "Rct1" Vitamin D and Metabolic And Endocrine Parameters In mentioning

confidence: 99%

Genetic Components of 25-Hydroxyvitamin D Increase in Three Randomized Controlled Trials

Trummer

Schweighofer

Haudum

et al. 2020

JCM

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“…Polycystic ovary syndrome (PCOS) and endometriosis, which are both associated with fertility problems, have also been associated with vitamin D deficiency in some but not all observational studies [ 46 , 50 ]. Importantly, there are also some papers about vitamin D RCTs in women with PCOS published that have, however, only inconsistently reported some beneficial effects of vitamin D supplementation on endocrine, metabolic and fertility aspects [ 50 , 59 ]. Many of these studies were limited by relatively small sample sizes and did not account for multiple testing problems [ 50 , 59 ].…”

Section: Fertilitymentioning

confidence: 99%

“…Importantly, there are also some papers about vitamin D RCTs in women with PCOS published that have, however, only inconsistently reported some beneficial effects of vitamin D supplementation on endocrine, metabolic and fertility aspects [ 50 , 59 ]. Many of these studies were limited by relatively small sample sizes and did not account for multiple testing problems [ 50 , 59 ]. Therefore, to date, no final conclusion can be drawn regarding potentially beneficial clinical effects of vitamin D on PCOS and its related pathologies [ 50 , 59 ].…”

Section: Fertilitymentioning

confidence: 99%

The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data

Pilz

Zittermann

Obeid

et al. 2018

IJERPH

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117

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Vitamin D deficiency is common and there exists a huge gap between recommended dietary vitamin D intakes and the poor vitamin D supply in the general population. While vitamin D is important for musculoskeletal health, there are accumulating data suggesting that vitamin D may also be important for fertility, pregnancy outcomes and lactation. Significant changes in vitamin D metabolism during pregnancy such as increased production of the “active vitamin D hormone” calcitriol support the important role of vitamin D in this setting. Observational studies show that vitamin D deficiency is a risk marker for reduced fertility and various adverse pregnancy outcomes and is associated with a low vitamin D content of breast milk. Meta-analyses of randomized controlled trials (RCTs) document that physiological vitamin D supplementation during pregnancy is safe and improves vitamin D and calcium status, thereby protecting skeletal health. Although certain RCTs and/or meta-analyses reported some other beneficial effects, it is still not clear whether vitamin D supplementation improves fertility or decreases the risk of adverse pregnancy outcomes such as low birth weight, pre-eclampsia and neonatal mortality, or reduces wheeze/asthma in the infants. Nevertheless, vitamin D supplementation in pregnant women is frequently required to achieve a sufficient vitamin D status as recommended by nutritional vitamin D guidelines. In this review, we provide an overview of systematic reviews, meta-analyses and large trials reporting clinical data on the role of vitamin D for fertility, pregnancy and lactation.

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“…However, several of these approaches, including the use of insulin-sensitizing drugs, often induce side effects. Therefore, new alternative strategies have been proposed to treat and or prevent InsR and metabolic abnormalities in PCOS [81]. The use of nutraceutical compounds may offer a new avenue for several adjunctive treatment strategies [82,83].…”

Section: Discussionmentioning

confidence: 99%

Targeting Metabolic Consequences of Insulin Resistance in Polycystic Ovary Syndrome by D-chiro-inositol and Emerging Nutraceuticals: A Focused Review

Davinelli

Nicolosi

Cesare

et al. 2020

JCM

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Polycystic ovary syndrome (PCOS) is a complex disorder associated with ovarian dysfunction, infertility, menstrual irregularity, and hormonal impairments. Over the last decade, several studies have shown that some PCOS women have insulin resistance (InsR) and hyperinsulinemia, apart from being overweight or obese. Therefore, a crucial clinical aspect is that PCOS patients might develop glucose intolerance and type 2 diabetes. Insulin-sensitizing drugs have been used as first-line treatment to improve hyperinsulinemia in women with PCOS. Although reducing PCOS symptoms and signs, several used insulin-sensitizer drugs may induce side effects, which reduces compliance. D-chiro-inositol (DCI), which is a naturally occurring stereoisomer of inositol, has been classified as an insulin-sensitizer and seems to mitigate multiple InsR-related metabolic alterations in PCOS with a safe profile. However, according to a multi-targeted design, the supplementation with DCI can be synergistically integrated by combining other potential insulin-sensitizing drugs and/or nutraceuticals. The literature provides the initial support for using several unexplored nutraceutical interventions that may target relevant metabolic abnormalities associated with InsR in PCOS. With a need to promote interest in clinical research, this review aims to discuss the efficacy of DCI and the role of emerging nutraceuticals for managing InsR in PCOS.

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Effects of vitamin D supplementation on metabolic and endocrine parameters in PCOS: a randomized-controlled trial

Abstract: Vitamin D supplementation had no significant effect on metabolic and endocrine parameters in PCOS with the exception of a reduced plasma glucose during OGTT.

Cited by 53 publications

References 38 publications

Genetic Components of 25-Hydroxyvitamin D Increase in Three Randomized Controlled Trials

Genetic Components of 25-Hydroxyvitamin D Increase in Three Randomized Controlled Trials

The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data

Targeting Metabolic Consequences of Insulin Resistance in Polycystic Ovary Syndrome by D-chiro-inositol and Emerging Nutraceuticals: A Focused Review

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