Effects of vitamin D supplementation on pulmonary function in postmenopausal women following an aquatic exercise program

Nolasco, Rodrigo; Moreira, Linda Denise Fernandes; Bocalini, Danilo S.; Fronza, Fernanda Cerveira Abuana Osório; Marin, Rosangela Villa; Lazaretti-Castro, Marise

doi:10.1590/2359-3997000000211

Cited by 9 publications

(5 citation statements)

References 28 publications

(29 reference statements)

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“…We observed an improvement in the spirometric parameters of women submitted to vitamin D supplementation, even without regular physical exercise. The supplemented group obtained a 7% improvement in peak expiratory flow, similarly forced vital capacity, according to the data presented in Figure 1 [42].…”

Section: Vitamin D Actions On the Respiratory Systemmentioning

confidence: 69%

“…Perhaps in future well-controlled studies, the parameters of cause and effect may be better supported. However, studies have shown that treatment with Vitamin D3 was effective in postmenopausal women to produce a significant increase in plasma concentrations of 25 (OH) D [42]. This adequacy of vitamin D status was associated with improved pulmonary function parameters, independent of the performance of the aquatic exercise program.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin D and Physical Performance: What Is the Ergogenic Actions of Vitamin D?

Nolasco¹,

Lazaretti‐Castro²

2019

Fads and Facts About Vitamin D

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Vitamin D produced in the skin by the action of the sun's rays turns into calcitriol, a powerful hormone, recognized as important for health. Although its most known effects are on mineral homeostasis and bone metabolism, its receptors (VDRs) have been identified in almost all tissues, suggesting that it should have other actions. Vitamin D acts directly on the skeletal muscle system maintaining muscle mass, strength levels and speed of muscle contraction. Thereby, allied to that, vitamin D is among the potential factors that are related to maintaining bone, and cannot be dissociated from the prevention of osteoporosis and sarcopenia. However, in the physical performance aspect, there are still uncertainness in the literature about the use of vitamin D as an ergogenic resource aimed at improving the physical performance of amateur and professional athletes. Therefore, due to the biological actions of vitamin D and high prevalence of low levels in sedentary and physically active individuals, this chapter will discuss the facts pointed out in the literature about the action of vitamin D as an ergogenic resource aiming at the preservation or improvement of the physical, including strength muscular, aerobic capacity and balance.

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Section: Vitamin D Actions On the Respiratory Systemmentioning

confidence: 69%

Section: Resultsmentioning

confidence: 99%

Vitamin D and Physical Performance: What Is the Ergogenic Actions of Vitamin D?

Nolasco¹,

Lazaretti‐Castro²

2019

Fads and Facts About Vitamin D

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“…What is more, some studies have linked vitamin D actions to restrained proliferation of metalloproteinases of the extracellular matrix (ECM), as well as the regulation of the synthesis to type III collagen by fibroblasts. Thus, the ECM of lung tissue plays an essential role in the pulmonary structures and mechanical properties, thus improving function [39].…”

Section: Discussionmentioning

confidence: 99%

Impact of Vitamin D in the improvement of respiratory function in sickle cell disease adult patients

Jabbar

Mohammed

Ibrahim

2023

Current Issues in Pharmacy and Medical Sciences

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The study aimed to discover the role of vitamin D in improving the respiratory function in sickle cell disease patients. In this prospective study, 188 adults were enrolled, drawn from the out-patients unit of Thalassemia Cente The collected data were categorized into three groups: group 1 included the data of 100 healthy individuals of age range of 18-50 years as control; group 2 included the data of 88 (40 males and 48 females) sickle cell disease patients in steady state before supplementation of vitamin D; group 3 represented the data of the same 88 sickle cell disease patients as measured and recorded after 6 weeks of vitamin D supplementation. Laboratory measurements including pulmonary function tests and hematological parameters, while vitamin D levels were estimated for all groups to compare the data before and after supplementation of vitamin We found significant differences in the pulmonary function tests when comparing groups. Mean value of FEV1 revealed significant differences between group 1 and 2 (p >0.05), while vitamin D supplement created a significant difference between group 2 and 3 (p >0.05). The improvement in FEV1 did not reach to that of healthy (group 1), as referred by the significant variation between group 1 and group 3 (p>0.05). The same findings were indicative within most pulmonary function tests, and the percentages of combined cases (restrictive and obstructive) were also deceased in group 3. Conclusion: supplement of vitamin D in SCD patients could result in relative improvement in lung function.

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“…Nevertheless, vitamin D plays a role in regulating human lung fibroblast functions in wound repair and tissue remodeling ( 31 ). In a post hoc analysis, vitamin D supplementation also improved spirometric parameters of lung function in postmenopausal women without regular practice of physical activity, compared with those not supplemented ( 32 ). Additionally, meta-analyses of trials in children, adults, and pregnant women showed that vitamin D supplementation can reduce the risk of exacerbations in patients with mild and moderate asthma who require corticosteroid treatment ( 33 , 34 ).…”

Section: Vitamin D and The Immune Response Against Respiratory Infect...mentioning

confidence: 99%

Reasons to avoid vitamin D deficiency during COVID-19 pandemic

Santos¹,

Maeda²,

Jardim³

et al. 2020

Archives of Endocrinology and Metabolism

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The effects of vitamin D on the musculoskeletal system are well established. Its deficiency causes osteomalacia, secondary hyperparathyroidism, and an increased risk for fractures and falls. However, clinical and experimental evidence points to extra-skeletal actions of vitamin D, including on immune and respiratory systems. Thus, during this COVID-19 pandemic, a possible deleterious role of vitamin D deficiency has been questioned. This paper aims to present a brief review of the literature and discuss, based on evidence, the role of vitamin D in the lung function and in the prevention of respiratory infections. Relevant articles were searched in the databases MEDLINE/PubMed and SciELO/LILACS. The mechanisms of vitamin D action in the immune system response will be discussed. Clinical data from systematic reviews and meta-analyses show benefits in the prevention of respiratory infections and improvement of pulmonary function when vitamin D-deficient patients are supplemented. At the time of writing this paper, no published data on vitamin D supplementation for patients with COVID-19 have been found. Vitamin D supplementation is recommended during this period of social isolation to avoid any deficiency, especially in the context of bone outcomes, aiming to achieve normal values of 25(OH)D. The prevention of respiratory infections and improvement of pulmonary function are additional benefits observed when vitamin D deficiency is treated. Thus far, any protective effect of vitamin D specifically against severe COVID-19 remains unclear. We also emphasize avoiding bolus or extremely high doses of vitamin D, which can increase the risk of intoxication without evidence of benefits.

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Effects of vitamin D supplementation on pulmonary function in postmenopausal women following an aquatic exercise program

Cited by 9 publications

References 28 publications

Vitamin D and Physical Performance: What Is the Ergogenic Actions of Vitamin D?

Vitamin D and Physical Performance: What Is the Ergogenic Actions of Vitamin D?

Impact of Vitamin D in the improvement of respiratory function in sickle cell disease adult patients

Reasons to avoid vitamin D deficiency during COVID-19 pandemic

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