Effects of vitamin D supplementation on depression and some involved neurotransmitters

Kaviani, Mina; Nikooyeh, Bahareh; Zand, Hamid; Yaghmaei, Parichehreh

doi:10.1016/j.jad.2020.03.029

Cited by 61 publications

(47 citation statements)

References 60 publications

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“…The large number of pathological features, identified lately, has stimulated the development of new theories, in an attempt to explain the triggering of clinical symptoms and dysfunctions. One of these most influential neurobiological perspectives is related to dysfunctions of monoaminergic neurotransmitters (serotonin, norepinephrine and dopamine), elucidating the need to enhance the activity of these monoamines (COWEN, 2016;KAVIANI et al, 2020) The proinflammatory condition in individuals with DD exhibits elevated levels of circulating proinflammatory cytokines (IL-1 IT-6 interleukins, tumor necrosis factor alpha (TNF-a) and some soluble interleukin receptors (stimulate the hypothalamic-axis). pituitaryadrenal-HPA), participate in the innate immune response and inflammation, have important metabolic effects, neurotransmitters, neuroendocrine function and neural plasticity, such as the administration of IL-6, which induces depressive behaviors and neutralizes fluoxetine's antidepressant effect in animals experimental (LIU et al, 2017;BERK et al, 2020) The compression of the interface between inflammation and depression has led to new questions and immunological investigations in depressed patients, requiring the development of more effective anti-inflammatory treatments (COWEN, 2016;LIU et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

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Neuronutrition in the perspective of the prevention and treatment of depressive disorder / Neuronutrição na perspectiva da prevenção e tratamento da desordem depressiva

Guedes¹,

Matias²

2021

Braz. J. Hea. Rev.

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The father of medicine was a pioneer in suggesting the healing power of food nutrients, however it took a long time for science to recognize that food has functional properties and the ability to interfere with mood and brain health. Currently, neuroscience is showing research results, demonstrating the effectiveness of nutritional bioactive compounds with neuroprotective potential. Some metabolic changes are the basis of common neuropsychiatric diseases, such as depressive disorder, characterized by mood dysregulation, cognitive dysfunction, sleep disorders, appetite, fatigue and metabolic or inflammatory changes. Objective: to describe the potential of dietary and bioactive nutrients that interfere in the neurobiology of depressive disorder. Methodology: This is a systematic review, stratified in a time window of 2012-2021. As a search criterion for the articles, a guiding question was formulated: how does the relationship between food nutrition and its potential connections in the neurobiology of depression appear? DesCs-MESH indexes were pre-established in the English language: food nutrition, bioactive, neurobiology depressive disorders, in the vernacular: food nutrition, brain, bioactive, depressive disorder, allied to Boolean operators, to the StArt resource, to exclude duplicate manuscripts. Results: This short-review included 31 articles that met the criteria and demonstrated nutritional bioactivity involved in the neurobiological process of depressive disorder. Conclusion: the connection between diet and depression emerges with promising perspectives when demonstrating the potential of nutrients and bioactive with a neuroprotective effect. The clinical approach combined with the diet designed to produce antidepressant effects can work as an adjunct to the treatment and prevention of depressive symptoms.

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Section: Discussionmentioning

confidence: 99%

“…According to the researchers, supplementation for eight weeks, dose: 50,000IU, is capable of significantly increasing serum concentrations of 25(OH) and reducing depressive symptoms (YOSAEE et al, 2020;KAVIANI et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Neuronutrition in the perspective of the prevention and treatment of depressive disorder / Neuronutrição na perspectiva da prevenção e tratamento da desordem depressiva

Guedes¹,

Matias²

2021

Braz. J. Hea. Rev.

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“…M. Kaviani i wsp. [49], prowadząc badania wśród osób dorosłych ze zdiagnozowaną łagodną lub umiarkowaną postacią depresji, także wykazali zmniejszenie stopnia nasilenia objawów depresyjnych pod wpływem zastosowanej suplementacji witaminą D 3 . Podobne wyniki przedstawili Y.Ch.…”

Section: Suplementacja Witaminą D W Leczeniu Depresjiunclassified

The role of vitamin D for the prevention and treatment of depression

Kurowska¹,

Antosik²,

Decyk³

et al. 2021

Med Og Nauk Zdr.

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Wprowadzenie. Wyniki badań ostatnich dziesięcioleci wykazują wzrost zachorowalności na chorobę psychiczną, jaką jest depresja. Światowa Organizacja Zdrowia (WHO) szacuje, że zaburzenie to dotyka ok. 264 mln ludzi na całym świecie i w ciągu najbliższych 20 lat stanie się najczęstszym problemem zdrowotnym. W przebiegu tej choroby znaczenie ma wiele czynników i mechanizmów, a jednym z nich może być niedobór witaminy D. Cel pracy. Celem pracy był przegląd aktualnej literatury analizującej wpływ niedoboru witaminy D na występowanie objawów depresji oraz możliwości zastosowania jej suplementacji jako jednej z metod leczenia. Metody przeglądu. Systematycznego przeglądu badań, opublikowanych od 1 stycznia 2015 do 31 stycznia 2021 roku, dokonano na podstawie przeszukiwania bibliograficznych baz danych takich jak: PubMed oraz Elsevier. Użyto następujących słów kluczowych i ich kombinacji: witamina D, 25-hydroksywitamina D, depresja, zaburzenia psychiczne, suplementacja witaminą D. Wyniki. Badania naukowe dostarczają dowodów na związek pomiędzy niedoborem 25(OH)D w surowicy krwi a zwiększonym ryzykiem wystąpienia depresji bądź nasilenia jej objawów wśród ludzi w różnym wieku. Badacze podkreślają istotną rolę suplementacji witaminą D3 -witamina ta może być stosowana w celu zmniejszenia nasilenia symptomów tego zaburzenia psychicznego lub jako środek wzmacniający leczenie farmakologiczne. Podsumowanie. Istnieje potrzeba dalszych badań, w szczególności randomizowanych, które będą w bardziej wiarygodny sposób wyjaśniać znaczenie witaminy D w przebiegu depresji oraz przedstawiać jej kliniczne zastosowanie w leczeniu tej choroby. Miałoby to znaczące korzyści nie tylko dla pojedynczych osób, ale również dla ogółu populacji, przyczyniając się do poprawy zdrowia w społeczeństwie.

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“…Corroborando os achados acima, Kaviani et al (2020) ao suplementar por oito semanas, doses de vitamina D 50.000 UI / 2 semanas, observaram um aumento expressivo nas concentrações séricas de 25 (OH) em pacientes com depressão leve e moderada, tendo assim, uma relevante melhora no perfil da patologia. Vellekkat e Menon (2019) também evidenciaram a eficácia positiva da suplementação oral e parenteral de vitamina D numa metanálise com 948 participantes, em quadro de depressão maior.…”

Section: Vitamina D E Depressãounclassified

O papel da alimentação no tratamento do transtorno de ansiedade e depressão

Rocha

Myva

Almeida

2020

RSD

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A ansiedade e a depressão são doenças mentais cada vez mais prevalentes no mundo que reduzem a qualidade de vida dos pacientes. Embora a medicação seja considerada a primeira linha de intervenção, muitos indivíduos não têm uma boa adesão ao tratamento. O acompanhamento nutricional e a fitoterapia surgem como recurso terapêutico na melhora dos sintomas e na promoção da saúde dessas patologias. Este estudo teve como objetivo compreender por meio de uma revisão da literatura o papel da alimentação e da fitoterapia no tratamento dos transtornos de ansiedade e depressão em população adulta e idosa. Para a pesquisa bibliográfica foi utilizada a base de dados PubMed, SciELO, ClinicalKey e CAPES com a seleção de artigos publicados em periódicos nacionais e internacionais, no período de 2010 a 2020. Verificou-se que a qualidade da dieta afeta o estado clínico geral do paciente e contribui de uma forma impactante na melhoria da saúde das patologias estudadas. Foi ressaltada a relevância de suplementar micronutrientes como, zinco, magnésio, vitaminas A, C, D, E e complexo B, bem como incluir fontes alimentares que contenham triptofano e ômega 3 para uma resposta benéfica no perfil da ansiedade e depressão. Assim, o cuidado nutricional é indicado, uma vez que as evidências apontam uma relação direta entre uma boa nutrição e a saúde mental.

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Effects of vitamin D supplementation on depression and some involved neurotransmitters

Cited by 61 publications

References 60 publications

Neuronutrition in the perspective of the prevention and treatment of depressive disorder / Neuronutrição na perspectiva da prevenção e tratamento da desordem depressiva

Neuronutrition in the perspective of the prevention and treatment of depressive disorder / Neuronutrição na perspectiva da prevenção e tratamento da desordem depressiva

The role of vitamin D for the prevention and treatment of depression

O papel da alimentação no tratamento do transtorno de ansiedade e depressão

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