Effects of Vitamin D Restricted Diet Administered during Perinatal and Postnatal Periods on the Penis of Wistar Rats

Fernandes-Lima, Flavia; Gregório, Bianca Martins; Nascimento, Francisco E. de L.; Costa, Waldemar S.; Gallo, C.; Sampaio, Francisco J.B.

doi:10.1155/2018/6030646

Cited by 3 publications

(5 citation statements)

References 49 publications

(57 reference statements)

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“…There are many risk factors in the etiology of ED which might be directly arising from VDD. Since the latest literature showed the importance of VD on erectile function, Fernandes-Lima et al [ 34 ] investigated the effects of VD restricted diet on Wistar rats offspring penis morphology. Fernandes-Lima et al [ 34 ] demonstrated that VD restriction during perinatal and postnatal periods induced metabolic and structural changes and represented important risk factors for ED in the penis of the adult offspring.…”

Section: Vitamin-d and Erectile Dysfunctionmentioning

confidence: 99%

“…Since the latest literature showed the importance of VD on erectile function, Fernandes-Lima et al [ 34 ] investigated the effects of VD restricted diet on Wistar rats offspring penis morphology. Fernandes-Lima et al [ 34 ] demonstrated that VD restriction during perinatal and postnatal periods induced metabolic and structural changes and represented important risk factors for ED in the penis of the adult offspring. The latter findings suggest that VD is an important micronutrient in maintaining the cytoarchitecture of the penis [ 34 ].…”

Section: Vitamin-d and Erectile Dysfunctionmentioning

confidence: 99%

“…Fernandes-Lima et al [ 34 ] demonstrated that VD restriction during perinatal and postnatal periods induced metabolic and structural changes and represented important risk factors for ED in the penis of the adult offspring. The latter findings suggest that VD is an important micronutrient in maintaining the cytoarchitecture of the penis [ 34 ]. In other words, human body requires VD for the proper anatomical development of the penis during embryonal life.…”

Section: Vitamin-d and Erectile Dysfunctionmentioning

confidence: 99%

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Vitamin D and Male Erectile Function: An Updated Review

Cangüven

Al-Malki

2021

World J Mens Health

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Literature support that vitamin-D is important for different systems of the human body including, but not limited to endocrine and immune systems, vasculature and endothelial function of the body. Male erectile function depends on many factors and can be perceived as a health indicator of the body. Epidemiological data have shown that vitamin-D deficiency is also associated with erectile dysfunction. In this review, our aim is to interpret the mechanisms by which vitamin-D might regulate anatomy and physiology of penis. Evidence showed that vitamin-D is needed for an adequate erectile function. Briefly, vitamin-D is crucial for a better healthy body and sexual activity.

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Section: Vitamin-d and Erectile Dysfunctionmentioning

confidence: 99%

Section: Vitamin-d and Erectile Dysfunctionmentioning

confidence: 99%

Section: Vitamin-d and Erectile Dysfunctionmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin D and Male Erectile Function: An Updated Review

Cangüven

Al-Malki

2021

World J Mens Health

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“…Vitamin D plays an important role in endothelial system health by providing blood pressure regulation through suppression of renin and also with direct effects such as anti-oxidative and anti-inflammatory [5][6][7][8]. It also plays an important role in providing an intact penis anatomy and histology and in the synthesis of nitric oxide, which is necessary in physiology of erection [6,9,10]. In addition, it is hypothesized that vitamin D may have an effect on the improvement of erectile function (EF) by its affinity on testosterone receptors [11].…”

Section: Introductionmentioning

confidence: 99%

Whether Adding Vitamin D to Tadalafil 5 mg Treatment Is Useful in Patients with Erectile Dysfunction and Vitamin D Deficiency?

Demirci¹,

Çakan²,

Topçuoğlu³

2021

Urol Int

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Introduction: Numerous factors such as endothelial disease and hormonal disorder cause the development of erectile dysfunction (ED). However, the relationship between vitamin D deficiency (VDD) and ED is unclear. Moreover, the benefit of vitamin D replacement on ED patients with VDD is uncertain. As far as we know, there is no study yet in the literature regarding the addition of vitamin D to phosphodiesterase type 5 inhibitors in the treatment of ED patients with VDD. In this study, we investigated whether adding vitamin D to daily tadalafil treatment would be beneficial in ED patients with VDD. Methods: A total of 111 patients with VDD accompanying ED were retrospectively evaluated between January 2016 and December 2019. Patients were divided into 2 groups according to the treatment they received. Group 1 (n = 58) was treated with daily oral tadalafil 5 mg, while group 2 (n = 53) received oral tadalafil 5 mg and 4,000 IU vitamin D3. Total International Index of Erectile Function-15 (IIEF-15) scores and vitamin D levels of the groups were compared at the end of the study. Results: The mean vitamin D level was increased statistically significant in group 2, but no difference was seen in group 1 (p < 0.001 and p > 0.05, respectively). There was a significant increase in median erectile function, orgasmic function, sexual desire, sexual satisfaction, and overall satisfaction scores in both groups (p < 0.001). However, the increase in median erectile function and sexual desire scores was significantly higher in group 2 compared to group 1 at the end of the study (p = 0.01 and p < 0.001, respectively). Conclusion: We found that adding vitamin D to 5 mg oral daily tadalafil treatment may have an additional positive effect on erectile function and sexual desire in ED patients with VDD.

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“…Serum vitamin D levels have an important function on calcium homoeostasis and bone metabolism. Accordingly, serum vitamin D levels are associated with calcifications of some soft tissues (Abedin, Tintut, & Demer, ; Fernandes‐Lima et al, ). The current molecular studies presented that Vitamin D increases the expression of TGF‐β1 and induces T‐cell differentiation by regulating the TGF‐β1 pathway (Zhou et al, ).…”

Section: Introductionmentioning

confidence: 99%

Is high levels of vitamin D a new risk factor for Peyronie's disease?

et al. 2019

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The aim of this study is to investigate whether serum vitamin D level predicts the risk of Peyronie's disease. Calcium and inflammatory cytokines play an important role during fibrocalcification of the plaques in Peyronie's Disease. TGF-β1 is one of the most fibrogenic cytokines. Increasing serum vitamin D levels is considered that induce expression of TGF-β1. Serum vitamin D levels and TGF-β1 are related with calcifications of some soft tissues in previous studies. One hundred and three Peyronie patients and 162 healthy volunteers were included in the study. In both groups, demographic data, medical history, physical examination and erectile capacity were recorded. Serum 25-hydroxyvitamin D, total cholesterol, low-density lipoprotein, high-density lipoprotein, triglyceride and testosterone levels were measured. The mean level of serum 25 (OH) D was significantly higher in men with Peyronie's disease compared with the controls (32.6 ± 7.9 ng/ml vs. 18.5 ± 6.6 ng/ml respectively. p < 0.001). There is a relationship between Peyronie's disease and high serum vitamin D levels. Also, increased low-density lipoprotein and total cholesterol levels, diabetes mellitus, and cardiovascular diseases were associated with Peyronie's disease. K E Y W O R D Spenile curvature, Peyronie's disease, plaque, vitamin D (Bollineni & Reddi, 1993). In addition, the severity of PD may correlate with DM has been shown (Kendirci, Trost, Sikka, & Hellstrom, 2007). In our study, 6.2% of patients had DM in control group and 26.2% of patients had DM in PD group (p < 0.001).Aetiologic impact of smoking is unclear in PD. Smoking has been shown as a PD risk factor in some studies. A retrospective case-control study showed that smoking was associated with PD (Bjekic et al., 2006). An another comparative clinical study showed that smoking was statistically higher in patients with PD than healthy population (Pavone et al., 2015). However, we did not find a significant relationship between smoking and PD (p = 0.375). Similarly, the impact of alcohol using is uncertain, although there are some studies showing that alcohol consumption is a risk factor for PD. Bjekic et al. found that alcohol consumption was related with PD (Bjekic et al., 2006).However, in the present study our results do not support this association (p = 0.468).Cholesterol is known a precursor of steroid hormones and has important roles in body metabolism. Hypercholesterolaemia and increased LDL levels are related with hyperlipidemia. Hyperlipidaemia is well known as a risk factor for vascular diseases. CVD is considered to lead of vascular weakness and facilitate the vascular damages during sexual intercourse. Therefore, hyperlipidaemia and CVD are risk factors for PD according to previous studies (Bjekic et al., 2006;Kadioglu et al., 2002;Muralidhar, Kumar, Sharma, Sharma, & Mandai, 1997). In our study, we found that increased CVD rates and high LDL/ total cholesterol levels were associated with PD.Our study has several limitations. Firstly, serum calcium and cavernosal TGF-β1 levels...

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Effects of Vitamin D Restricted Diet Administered during Perinatal and Postnatal Periods on the Penis of Wistar Rats

Cited by 3 publications

References 49 publications

Vitamin D and Male Erectile Function: An Updated Review

Vitamin D and Male Erectile Function: An Updated Review

Whether Adding Vitamin D to Tadalafil 5 mg Treatment Is Useful in Patients with Erectile Dysfunction and Vitamin D Deficiency?

Is high levels of vitamin D a new risk factor for Peyronie's disease?

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