Effects of vitamin D on sex steroids, luteinizing hormone, and testosterone to luteinizing hormone ratio in 307 infertile men

Holt, Rune; Yahyavi, Sam Kafai; Kooij, Ireen; Poulsen, Nadia Nicholine; Juul, Anders; Jørgensen, Niels; Jensen, Martin Blomberg

doi:10.1111/andr.13505

Cited by 4 publications

(2 citation statements)

References 68 publications

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“…Vit-D receptors were found in testicular tissue, especially Leydig cells, where the vitamin is locally activated [ 95 ] and stimulates the synthesis of testosterone [ 96 , 97 ]. Men with Vit-D deficiency and insufficiency display reduced levels of serum testosterone and lower testosterone-to-luteinizing hormone ratio, indicating that sufficient exposure to vitamin D is required to sustain the testicular synthesis of testosterone [ 98 ]. Vit-D deficiency and male hypogonadism usually coexist and are both independent risk factors for frailty [ 99 ].…”

Section: Preventing Sarcopenia: a Therapeutic Target In Primary And S...mentioning

confidence: 99%

Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age

Lisco,

Disoteo,

De Tullio

et al. 2023

Nutrients

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Sarcopenia is an age-related clinical complaint characterized by the progressive deterioration of skeletal muscle mass and strength over time. Type 2 diabetes (T2D) is associated with faster and more relevant skeletal muscle impairment. Both conditions influence each other, leading to negative consequences on glycemic control, cardiovascular risk, general health status, risk of falls, frailty, overall quality of life, and mortality. PubMed/Medline, Scopus, Web of Science, and Google Scholar were searched for research articles, scientific reports, observational studies, clinical trials, narrative and systematic reviews, and meta-analyses to review the evidence on the pathophysiology of di-abetes-induced sarcopenia, its relevance in terms of glucose control and diabetes-related outcomes, and diagnostic and therapeutic challenges. The review comprehensively addresses key elements for the clinical definition and diagnostic criteria of sarcopenia, the pathophysiological correlation be-tween T2D, sarcopenia, and related outcomes, a critical review of the role of antihyperglycemic treatment on skeletal muscle health, and perspectives on the role of specific treatment targeting myokine signaling pathways involved in glucose control and the regulation of skeletal muscle metabolism and trophism. Prompt diagnosis and adequate management, including lifestyle inter-vention, health diet programs, micronutrient supplementation, physical exercise, and pharmaco-logical treatment, are needed to prevent or delay skeletal muscle deterioration in T2D.

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Section: Preventing Sarcopenia: a Therapeutic Target In Primary And S...mentioning

confidence: 99%

Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age

Lisco,

Disoteo,

De Tullio

et al. 2023

Nutrients

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show abstract

“…Wholebody dual-energy x-ray absorptiometry (DXA) scan was performed on day 1 and on day 150 with light clothing to determine total body composition, including total fat mass in percentage (Lunar Prodigy, GE Healthcare). Reproductive hormones were also measured and have previously been published (10,13,14) .…”

Section: Biochemical Analysismentioning

confidence: 99%

High-dose cholecalciferol supplementation to obese infertile men is sufficient to reach adequate vitamin D status

Holt,

Jorsal,

Yahyavi

et al. 2023

Br J Nutr

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Obesity is associated with low vitamin D status and the optimal supplement and dosage of cholecalciferol (vitamin D3) or calcidiol (25OHD) for individuals with obesity has been debated. We aimed to determine the effect of high-dose vitamin D3 supplementation on achieving adequate vitamin D levels among infertile men with normal weight versus obesity. Here, we present secondary endpoints from a single-center, double-blinded, randomized clinical trial, comprising of 307 infertile men randomized to active or placebo treatment for 150 days. Men in the active group initially received an oral bolus of 300,000 IU vitamin D3, followed by daily supplementation with 1,400 IU vitamin D3 and 500 mg calcium. Baseline body mass index (BMI) was listed as a predefined subgroup. At baseline, serum 25OHD was significantly higher in men with normal weight (BMI < 25 kg/m2) compared with men with overweight (BMI 25-30 kg/m2) and obesity (BMI > 30 kg/m2) (48 nmol/L vs. 45 nmol/L and 39 nmol/L, respectively; p = 0.024). After the intervention, both men with normal weight, overweight and obesity treated with vitamin D3 had a significantly higher serum 25OHD compared with corresponding placebo-treated men (BMI < 25 kg/m2: 92 nmol/L vs. 53 nmol/L, BMI = 25-30 kg/m2: 87 nmol/L vs. 49 nmol/L and BMI > 30 kg/m2: 85 nmol/L vs. 48 nmol/L; p < 0.001 for all respectively). In conclusion, we show high-dose vitamin D3 supplementation to infertile men with obesity and low vitamin D status, is sufficient to achieve adequate serum 25OHD levels.

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High-dose vitamin D3 supplementation shows no beneficial effects on white blood cell counts, acute phase reactants, or frequency of respiratory infections

Wall-Gremstrup,

Holt,

Yahyavi

et al. 2024

Respir Res

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Background Vitamin D has been suggested to influence the immune system, and vitamin D metabolites and the vitamin D receptor (VDR) are generated and expressed in white blood cells (WBC). Moreover, vitamin D status has been associated with incidence and prognosis of some respiratory tract infections (RTI). Therefore, we investigated the effect of vitamin D3 supplementation on WBC, acute phase reactants (APR), and the risk of developing RTIs. Methods A double-blinded, randomized, placebo-controlled clinical trial of 307 infertile men with multiple secondary immunological endpoints. The vitamin D3 group (n = 151) initially received 300,000 IU (7,500 µg) cholecalciferol once - followed by 1,400 IU (35 µg) daily for 150 days. The placebo group (n = 156) did not receive active ingredients. Results At baseline, stratification into clinically relevant groups of vitamin D status (< 25; 25–50; 50–75; >75 nmol/L), showed an inverse association with total leucocyte concentrations (7.0 vs. 6.0 vs. 6.0 vs. 5.5 (109/L); p = 0.007), lymphocytes (2.4 vs. 2.1 vs. 2.0 vs. 2.0 (109/L); p = 0.048), CRP (2.0 vs. 1.7 vs. 1.2 vs. 1.2 (mg/L); p = 0.037), and orosomucoid (0.82 vs. 0.77 vs. 0.76 vs. 0.70 (g/L); p = 0.015). After 150 days, no differences were detected in WBC counts or APRs between the vitamin D3 and the placebo group. However, vitamin D3 treated men had a higher prevalence of self-reported RTIs compared with the placebo group (55% vs. 39%; p = 0.005). Conclusions High-dose vitamin D3 supplementation did not alter WBCs or APRs, but a higher prevalence of respiratory infections was observed in the vitamin D3 group. Serum 25(OH)D3 was negatively correlated with most WBCs, indicating that vitamin D status may be linked with inflammation and WBC turnover, but not an important determinant of developing RTIs. Trial registration NCT01304927 (ClinicalTrials.gov). Registered February 20, 2011.

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Effects of vitamin D on sex steroids, luteinizing hormone, and testosterone to luteinizing hormone ratio in 307 infertile men

Cited by 4 publications

References 68 publications

Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age

Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age

High-dose cholecalciferol supplementation to obese infertile men is sufficient to reach adequate vitamin D status

High-dose vitamin D3 supplementation shows no beneficial effects on white blood cell counts, acute phase reactants, or frequency of respiratory infections

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