Effects of vitamin D deficiency on the relapse, severity, and disability of multiple sclerosis

El-Sherif, Mohammed; Esmael, Ahmed; Elazzouny, AymanA

doi:10.4103/1110-1083.193086

Cited by 1 publication

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“…Studies on MS patients have suggested that taking adequate vitamin D can modulate the course of MS and leads to lower incidence of MS [8][9][10]. However, studies on the relationship between MS severity and MS course and vitamin D intake are limited and reported conflicting findings [11,12]. Moreover, the main source of vitamin D in the body is sunlight exposure.…”

Section: Introductionmentioning

confidence: 99%

Association Between Sunlight Exposure and Vitamin D Intake and Multiple Sclerosis Disability and Progression

Fayyazi¹,

Shaygannejad

Maljaie³

et al. 2018

Caspian.J.Neurol.Sci

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Background: Some studies on Multiple Sclerosis (MS) have suggested that adequate vitamin D intake can modulate the course of MS and decreases its incidence. However, there are limited studies with conflicting findings on the relation between MS severity, its course, and vitamin D intake. Objectives: The current study aimed to compare vitamin D intake and sunlight exposure between MS phenotypes and evaluate their association with disability and fatigue in each phenotype. Materials & Methods: A total of 197 patients with MS were recruited from patients referring to MS clinic in Kashani Hospital in Isfahan, Iran. Subjects were assessed for sunlight exposure, vitamin D intake, physical activity, and fatigue. SPSS was used for statistical analysis. P<0.05 were set as significant. Results: According to the obtained results, expanded disability status scale and fatigue scale scores in Primary-Progressive MS (PPMS) and Secondary-Progressive MS (SPMS) groups were higher than Relapsing-Remitting MS (RRMS) group. In addition, patients in RRMS group had higher scores of sun exposure and physical activity, compared to SPMS and PPMS groups. We found a negative correlation between the scores of fatigue scale and sunlight exposure scale in RRMS patients. Conclusion: We found higher sunlight exposure in RRMS group and lower sunlight exposure in the PPMS group, while dietary vitamin D intake was not different between the groups. Further studies with larger sample sizes and stronger methodologies are required to evaluate our findings.

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