Effects of vitamin D deficiency in critically ill surgical patients

Flynn, Lisa; Zimmerman, Lisa Hall; McNorton, Kelly; Dolman, Mortimer; Tyburski, James G.; Baylor, Alfred E.; Wilson, Robert S.; Dolman, Heather

doi:10.1016/j.amjsurg.2011.09.012

Cited by 94 publications

(86 citation statements)

References 12 publications

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“…32 Correlation between vitamin D sufficiency and decreased mortality has not been observed in all studies. In 2 studies 33,34 of critically ill patients with smaller sample sizes, vitamin D deficiency was associated with longer length of stay and a trend toward higher rates of infection and sepsis; however, the increase in mortality did not differ significantly between patients who were deficient in vitamin D and patients who were not. In a study 35 of 170 patients, 92 with sepsis and 72 with trauma, patients with sepsis had significantly lower mean serum levels of 25-hydroxyvitamin D on admission.…”

Section: Multivariate Analysismentioning

confidence: 99%

Deficiency in 25-Hydroxyvitamin D and 30-Day Mortality in Patients With Severe Sepsis and Septic Shock

Rech

Hunsaker

Rodriguez

2014

American Journal of Critical Care

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Background Vitamin D has immunomodulating properties. Objective To determine if vitamin D deficiency within 30 days of admission to the intensive care unit in patients with sepsis might be associated with increased all-cause 30-day mortality. Methods In a retrospective cohort study at a large, tertiary, urban, academic medical center, records of patients who had 25-hydroxyvitamin D levels measured within 30 days of admission for severe sepsis or septic shock from June 2006 to April 2011 were examined. Patients were considered deficient in vitamin D if its serum concentration was 15 ng/mL or less. The primary outcome of interest was 30-day mortality. Results Among the 121 patients in the sample, 65 (54%) were vitamin D deficient. Baseline demographics were similar between vitamin D deficient and nondeficient groups, except that the vitamin D deficient group had more African Americans (P = .01). All-cause 30-day mortality was significantly higher in patients deficient in vitamin D (37% vs 20%; P = .04) and remained higher at 90 days (51% vs 25%, P = .005). In multivariate analysis, age (odds ratio, 1.04; 95% CI 1.01–1.07; P = .01) and vitamin D deficiency (odds ratio, 2.7; 95% CI, 1.39–18.8; P = .02) were independently associated with increased 30-day mortality. Conclusion Patients deficient in vitamin D within 30 days of hospital admission for severe sepsis or septic shock may be at increased risk for all-cause 30-day mortality.

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Section: Multivariate Analysismentioning

confidence: 99%

Deficiency in 25-Hydroxyvitamin D and 30-Day Mortality in Patients With Severe Sepsis and Septic Shock

Rech

Hunsaker

Rodriguez

2014

American Journal of Critical Care

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“…Some researchers could not find any correlation between nosocomial infections and 25 (OH) D levels, while others observed that low levels of vitamin D were associated with a trend toward increased risk of ICU-acquired infections. However, only a few of these relationships were statistically significant (14,28,34). Mixed results were also reported for mortality rates (4,17,27,35).…”

Section: Discussionmentioning

confidence: 74%

“…In a retrospective cohort study with 2399 patients, 25 (OH) D levels lower than 15 ng/mL were associated with blood culture positivity. Cutoff values of 20 and 30 ng/mL were also studied in various cohorts and found to be significantly associated with sepsis (17)(18)(19)(20)(21)(22)(23)(28)(29)(30)(31)(32)(33).…”

Section: Discussionmentioning

confidence: 99%

Low levels of vitamin D are associated with nosocomial infections but not with short-term mortality in critically ill patients

2018

Turk J Med Sci

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“…Evidence in support of this hypothesis came from studies that showed secondary hyperparathyroidism was linked to hypocalcemia and low 25(OH)D3 levels [23][24][25].…”

Section: Vitamin D and Metabolitesmentioning

confidence: 83%

Hypocalcemia in the Critically Ill: A Mini-Review

Naafs¹

2017

EMIJ

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In this mini-review of hypocalcemia in the critically ill patient historical and new insights in the function of the PTH-vitamin D axis are discussed Special attention is given to the role of locally tissue produced calcitriol in the immune system and in the inflammatory cytokine response of the vitamin D deficiënt critically ill patient.Future directions in this research area and in the forthcoming research on the use of the anabolic recombinant PTH analogues in critical care medicine are discussed.

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Effects of vitamin D deficiency in critically ill surgical patients

Cited by 94 publications

References 12 publications

Deficiency in 25-Hydroxyvitamin D and 30-Day Mortality in Patients With Severe Sepsis and Septic Shock

Deficiency in 25-Hydroxyvitamin D and 30-Day Mortality in Patients With Severe Sepsis and Septic Shock

Low levels of vitamin D are associated with nosocomial infections but not with short-term mortality in critically ill patients

Hypocalcemia in the Critically Ill: A Mini-Review

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