Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast cells

Guan, Zhong; Li, Huaifang; Guo, Lili; Xiang, Yang

doi:10.1007/s00404-015-3647-8

Cited by 15 publications

(9 citation statements)

References 25 publications

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“…We and others have recently reported that hydrogen is also effective for pulmonary hypertension . The effects of hydrogen have been also reported in perinatal disorders: neonatal cerebral hypoxia; LPS‐induced fetal lung injury; preeclampsia; and perinatal brain injury caused by prenatal inflammation …”

Section: Introductionmentioning

confidence: 81%

Hydrogen-rich water ameliorates bronchopulmonary dysplasia (BPD) in newborn rats

et al. 2016

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Bronchopulmonary dysplasia (BPD) is characterized by developmental arrest of the alveolar tissue. Oxidative stress is causally associated with development of BPD. The effects of hydrogen have been reported in a wide range of disease models and human diseases especially caused by oxidative stress. We made a rat model of BPD by injecting lipopolysaccharide (LPS) into the amniotic fluid at E16.5. The mother started drinking hydrogen-rich water from E9.5 and also while feeding milk. Hydrogen normalized LPS-induced abnormal enlargement of alveoli at P7 and P14. LPS increased staining for nitrotyrosine and 8-OHdG of the lungs, and hydrogen attenuated the staining. At P1, LPS treatment decreased expressions of genes for FGFR4, VEGFR2, and HO-1 in the lungs, and hydrogen increased expressions of these genes. In contrast, LPS treatment and hydrogen treatment had no essential effect on the expression of SOD1. Inflammatory marker proteins of TNFα and IL-6 were increased by LPS treatment, and hydrogen suppressed them. Treatment of A549 human lung adenocarcinoma epithelial cells with 10% hydrogen gas for 24 hr decreased production of reactive oxygen species in both LPS-treated and untreated cells. Lack of any known adverse effects of hydrogen makes hydrogen a promising therapeutic modality for BPD. Pediatr Pulmonol. 2016; 51:928-935. © 2016 Wiley Periodicals, Inc.

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Section: Introductionmentioning

confidence: 81%

Hydrogen-rich water ameliorates bronchopulmonary dysplasia (BPD) in newborn rats

et al. 2016

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“…To the best of our knowledge, this is the only study so far where vitamin E, in the form of TRF from palm oil, demonstrated protection against PIH and preeclampsia. Other studies do not support the role of vitamin E in preventing either preeclampsia or PIH (18,(27)(28)(29)(30)(31)(32)(33)(34). However, the other studies used vitamin E in the form of the much weaker antioxidant tocopherol, either as a monotherapy or in combination with vitamin C.…”

Section: Discussionmentioning

confidence: 99%

“…The significant evidence of oxidative stress playing a key role in the development of preeclampsia directed to the hypothesis that antioxidant supplementation may have a role in preventing the disease. The potential of antioxidants such as vitamins C, E, selenium and lycopene (17) in the prevention of conditions associated with oxidative stress like preeclampsia, is supported by evidence-based studies (18)(19)(20)(21).…”

Section: Introductionmentioning

confidence: 98%

Role of Palm Oil Vitamin E in Preventing Pre-eclampsia: A Secondary Analysis of a Randomized Clinical Trial Following ISSHP Reclassification

2021

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Background: Preeclampsia is a significant cause of maternal and perinatal mortality worldwide. Oxidative stress plays a key role in its pathophysiology, hence antioxidants such as tocotrienol may be preventive against preeclampsia. In 2018, the ISSHP revised the definition of preeclampsia. In accordance with the new definition, we report a secondary data analysis from a clinical trial comparing palm oil vitamin E in the form of tocotrienol-rich fraction (TRF) against placebo, in preventing preeclampsia.Method: A randomized double-blind controlled trial was conducted in 2002–2005 to assess the benefits of TRF in preeclampsia prevention. A total of 299 primigravidae were recruited. The intervention group was supplemented with TRF 100 mg daily in super-olein capsules, whereas the placebo group was prescribed super-olein capsules without TRF, beginning from 12 to 16 gestational weeks until delivery. The primary outcome measure was incidence of preeclampsia.Results: The total incidence of pregnancy induced hypertension (PIH) was 5%, whereas the incidence of preeclampsia was 2.3%. The odds of developing PIH (adjusted OR 0.254; 95% CI: 0.07–0.93; p–value 0.038) and preeclampsia (adjusted OR 0.030; 95% CI: 0.001–0.65; p-value 0.025) were significantly lower in the TRF arm compared to the placebo arm.Conclusion: Antenatal supplementation with palm oil vitamin E in the form of TRF is associated with significant reductions in the incidence of preeclampsia and PIH in a single urban tertiary hospital. Palm oil vitamin E deserves further scrutiny as a potential public health preventive measure against preeclampsia and PIH.

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“…During embryo development and pregnancy, oxidative stress can lead to different tissue alterations and newborn diseases [253] [254]. The use of hydrogen as a possible therapeutic approach for diseases during pregnancy has been tested in vitro with trophoblast cell lines (JAR, JEG-3) [255]. This is important, as treatments with antioxidant vitamins (C and E) have been shown to be detrimental on placental function, as determined by decreased cell viability, decreased secretion of hormones and increased production of tumor necrosis factor-α.…”

Section: Hydrogen In Reproductive Tissues Pregnancy Neonatal Develomentioning

confidence: 99%

“…In contrast to vitamins, hydrogen does not cause any detrimental effects. Moreover, molecular hydrogen promoted the secretion of human chorionic gonadotrophin (hCG) by these cells, suggesting that hydrogen might be a suitable antioxidant for the management of diseases, such as preclampsia during pregnancy [255]. The administration of hydrogen to pregnant rats has been reported to be beneficial for ischemia/reperfusion injury and hippocampal damage in fetal rats [256].…”

Section: Hydrogen In Reproductive Tissues Pregnancy Neonatal Develomentioning

confidence: 99%

Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine

Nicolson¹,

Ferreira²,

Settineri³

et al. 2016

IJCM

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Here we review the literature on the effects of molecular hydrogen (H2) on normal human subjects and patients with a variety of diagnoses, such as metabolic, rheumatic, cardiovascular and neurodegenerative and other diseases, infections and physical and radiation damage as well as effects on aging and exercise. Although the effects of H2 have been studied in multiple animal models of human disease, such studies will not be reviewed in depth here. H2 can be administered as a gas, in saline implants or infusions, as topical solutions or baths or by drinking H2-enriched water. This latter method is the easiest and least costly method of administration. There are no safety issues with hydrogen; it has been used for years in gas mixtures for deep diving and in numerous clinical trials without adverse events, and there are no warnings in the literature of its toxicity or longterm exposure effects. Molecular hydrogen has proven useful and convenient as a novel antioxidant and modifier of gene expression in many conditions where oxidative stress and changes in gene expression result in cellular damage.

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Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast cells

Cited by 15 publications

References 25 publications

Hydrogen-rich water ameliorates bronchopulmonary dysplasia (BPD) in newborn rats

Hydrogen-rich water ameliorates bronchopulmonary dysplasia (BPD) in newborn rats

Role of Palm Oil Vitamin E in Preventing Pre-eclampsia: A Secondary Analysis of a Randomized Clinical Trial Following ISSHP Reclassification

Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine

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