Effects of vitamin C supplementation on the blood oxidative stress and antibody titre against <i>Histophilus somni</i> vaccination in calves

Otomaru, Konosuke; Oishi, Shoko; Fujimura, Yu; Iwamoto, Yuki; Nagai, Katsuhisa; Ijiri, Moe

doi:10.2478/jvetres-2021-0002

Cited by 8 publications

(5 citation statements)

References 17 publications

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“…It is also of note that, to the best of our knowledge, despite stimulatory influence of vitamin C [63,64], selenium [65] and manganese [66] on antibody synthesis in humans and/or experimental animals, there is no studies on their influence on serological response to influenza virus vaccine. However, there are data indicating that they exert stimulatory influence on antibody response to some other vaccine, including (when selenium is in question) avian influenza virus in humans and/or experimental animals [67][68][69][70][71].…”

Section: Discussionmentioning

confidence: 99%

Modulation of T-cell-dependent humoral immune response to influenza vaccine by multiple antioxidant/immunomodulatory micronutrient supplementation

Bufan,

Arsenović-Ranin,

Živković

et al. 2024

Preprint

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In spite of prevalence gaps in several micronutrients supporting immune function, significance of their deficits/supplementation for efficacy of vaccines is underinvestigated. Thus, influence of supplementation combining vitamins C and D, zinc, selenium and manganese, and N-acetyl-cysteine on mouse IgG responses and underlying mechanisms to seasonal quadrivalent influenza vaccine (QIV) was investigated. QIV was given in two doses (28 days apart). The supplementation starting 5 days before the first injection increased the total serum IgG titre, through stimulation of germinal centre (GC) reaction in secondary lymphoid organs (SLOs), as indicated by increase in the frequency of GC B cells and follicular CD4+ T helper (Th) cells, and IL-21-producing Th cells. Additionally, the supplementation “optimized” IgG response following the second QIV injection by supporting more favorable (in respect to virus clearance) IgG2a response through favoring Th1 differentiation as indicating by Th1 (INF-γ) /Th2 (IL-4) signature cytokine level ratio upon QIV restimulation in SLO cell cultures. This most likely reflected partly their antioxidant action (as indicated by redox status analyses) on Th cell differentiation. Thus, the study forms solid base for further research aimed at repurposing use this safe and inexpensive micronutrient combination as an adjuvant for virus influenza vaccine.

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Section: Discussionmentioning

confidence: 99%

Modulation of T-cell-dependent humoral immune response to influenza vaccine by multiple antioxidant/immunomodulatory micronutrient supplementation

Bufan,

Arsenović-Ranin,

Živković

et al. 2024

Preprint

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“…This agrees with the values recorded in human samples [ 13 ], in which the LOOH levels assessed using a ROMs test were 350 times higher than those obtained using a TOS assay, and far beyond the cytotoxicity threshold indicated in the literature [ 4 , 17 ]. At the same time, ROMs-assessed LOOH values in livestock species are remarkably lower than in humans [ 25 , 26 , 28 , 42 ], whereas TOS-assessed LOOH values do not greatly differ between livestock species and humans [ 43 , 44 , 45 , 46 ]. This discrepancy may be attributable to the higher CP oxidase activity in humans than in animal species [ 23 , 47 , 48 , 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

Ceruloplasmin Interferes with the Assessment of Blood Lipid Hydroperoxide Content in Small Ruminants

Gualandi

Boni

2023

Antioxidants

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Simple and inexpensive analytical methods for assessing redox balance in biological matrixes are widely used in animal and human diagnostics. Two of them, reactive oxygen metabolites (ROMs) and total oxidant status (TOS), evaluate the lipid hydroperoxide (LOOH) content of the sample and are based on iron-mediated mechanisms. However, these tests provide uncorrelated results. In this study, we compared these two tests in the blood serum of goat kids and lambs, together with an evaluation of ceruloplasmin (CP) oxidase activity. No significant correlation was found between ROMs and TOS, or between TOS and CP oxidase activity, in either species. Conversely, ROMs and CP oxidase activity were highly correlated in both kid and lamb samples (p < 0.001). A significant progressive reduction in the analytical signal in the ROMs assay was observed when sodium azide, an effective CP inhibitor, was added to the samples before the assay (p < 0.001). This decrease was related to sodium azide concentration (p < 0.01) and was not found when sodium azide was added at the same concentrations in the TOS assay. These findings suggest that ROMs, unlike TOS, may be affected by CP, which interferes with LOOH detection in blood samples.

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“…Vaccination against SARS-CoV-2 and the resultant activation of the immune system is likely to result in enhanced utilisation of immune supportive micronutrients, such as vitamin C. In cases of severe vitamin C deficiency, infants have been observed to go into shock following routine childhood vaccinations; rapid vitamin C administration was able to rescue many cases [ 64 , 65 ]. Animal studies have indicated that administration of vitamin C during vaccination or antigen challenge can stimulate an earlier and higher antibody response [ 66 , 67 , 68 ].…”

Section: Immunisation Supportmentioning

confidence: 99%

Multi-Level Immune Support by Vitamins C and D during the SARS-CoV-2 Pandemic

Carr

Gombart

2022

Nutrients

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Vitamins C and D have well-known immune supportive roles, with deficiencies in both vitamins predisposing to increased risk and severity of respiratory infections. Numerous studies have indicated that administration of these vitamins, particularly to people who are deficient, can decrease the risk and severity of respiratory infections. This has stimulated an interest in the potential efficacy of these vitamins in people with novel coronavirus (SARS-CoV-2) infection and its more severe disease (COVID-19). In this overview, we highlight the current research evidence around the multiple levels of immune support provided by vitamins C and D in the context of general respiratory infections and with a focus on the current SARS-CoV-2 pandemic. These include: prevention of infection; attenuating infection symptoms and severity; adjunctive therapy for severe disease; attenuating ongoing sequelae (e.g., long COVID); and immunisation support. Although some of these topics have not yet been investigated in great depth concerning SARS-CoV-2 and COVID-19, extensive research into the role of these vitamins in general respiratory infections has highlighted directions for future research in the current pandemic.

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Effects of vitamin C supplementation on the blood oxidative stress and antibody titre against Histophilus somni vaccination in calves

Cited by 8 publications

References 17 publications

Modulation of T-cell-dependent humoral immune response to influenza vaccine by multiple antioxidant/immunomodulatory micronutrient supplementation

Modulation of T-cell-dependent humoral immune response to influenza vaccine by multiple antioxidant/immunomodulatory micronutrient supplementation

Ceruloplasmin Interferes with the Assessment of Blood Lipid Hydroperoxide Content in Small Ruminants

Multi-Level Immune Support by Vitamins C and D during the SARS-CoV-2 Pandemic

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