Effects of vitamin C stimulation on rehabilitation of dysphagia after stroke: a randomized trial

Wang, Jiongmei; Chang, Enoch H.; Jiang, Yujuan

doi:10.23736/s1973-9087.22.07337-3

Cited by 8 publications

(6 citation statements)

References 30 publications

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“…For the influence of rehabilitation therapy on biomarkers in peripheral blood in stroke patients, the meta-analysis revealed a low-quality evidence that the concentrations of superoxide dismutase (SOD) ( 17 , 19 , 27 , 42 ), albumin (ALB) ( 31 , 32 , 37 ), hemoglobin (HB) ( 20 , 22 , 31 , 37 ), and catalase (CAT) ( 17 , 19 , 42 ) significantly increased in peripheral blood in the treated group, and that this was significantly associated with improvement in function after stroke ( Supplementary Figures S10–S13 ; Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Biomarkers associated with functional improvement after stroke rehabilitation: a systematic review and meta-analysis of randomized controlled trials

Chen,

Wu,

Chen

et al. 2023

Front. Neurol.

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ObjectiveThis study aims to identify blood and cerebrospinal fluid biomarkers that are correlated to the functional improvement of stroke patients after rehabilitation therapy, and provide ideas for the treatment and evaluation of stroke patients.MethodsThe PubMed, Web of Science, and Embase databases were searched for articles published in the English language, from inception to December 8, 2022.ResultsA total of 9,810 independent records generated 50 high-quality randomized controlled trials on 119 biomarkers. Among these records, 37 articles were included for the meta-analysis (with a total of 2,567 stroke patients), and 101 peripheral blood and cerebrospinal fluid biomarkers were included for the qualitative analysis. The quantitative analysis results revealed a moderate quality evidence that stroke rehabilitation significantly increased the level of brain-derived neurotrophic factor (BDNF) in serum. Furthermore, the low-quality evidence revealed that stroke rehabilitation significantly increased the concentration of serum noradrenaline (NE), peripheral blood superoxide dismutase (SOD), peripheral blood albumin (ALB), peripheral blood hemoglobin (HB), and peripheral blood catalase (CAT), but significantly decreased the concentration of serum endothelin (ET) and glutamate. In addition, the changes in concentration of these biomarkers were associated with significant improvements in post-stroke function. The serum BNDF suggests that this can be used as a biomarker for non-invasive brain stimulation (NIBS) therapy, and to predict the improvement of stroke patients.ConclusionThe concentration of serum BNDF, NE, ET and glutamate, and peripheral blood SOD, ALB, HB and CAT may suggest the function improvement of stroke patients.

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Section: Resultsmentioning

confidence: 99%

Biomarkers associated with functional improvement after stroke rehabilitation: a systematic review and meta-analysis of randomized controlled trials

Chen,

Wu,

Chen

et al. 2023

Front. Neurol.

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“…Previous studies investigating neurogenic swallowing dysfunction found that subjects consuming water with a citric acid concentration of 2.7%, compared to plain water, exhibited increased spontaneous swallowing and reduced aspirations, leading to an improvement in swallowing function ( Pelletier and Lawless, 2003 ). Wang et al (2022) reported an effective acid stimulation medium for treating dysphagia in stroke patients. This method entailed applying vitamin C tablet powder (0.2 g/day) to the patient’s bilateral tongue using a cotton swab, followed by swallowing practice instructions.…”

Section: Physical Therapymentioning

confidence: 99%

“…Additionally, tongue massage with the cotton swab and guidance for tongue and masticatory muscle exercises were included (5–6 times per day, 15 min each time for 2 weeks). Acid stimulation promotes saliva secretion by stimulating the tongue, thereby accelerating the swallowing process and relieving swallowing disorders ( Wang et al, 2022 ). Acid stimulation effectively improves stroke dysphagia based on two fundamental principles.…”

Section: Physical Therapymentioning

confidence: 99%

The impact of physical therapy on dysphagia in neurological diseases: a review

Li,

Fu,

Xie

et al. 2024

Front. Hum. Neurosci.

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A neurogenic dysphagia is dysphagia caused by problems with the central and peripheral nervous systems, is particularly prevalent in conditions such as Parkinson’s disease and stroke. It significantly impacts the quality of life for affected individuals and causes additional burdens, such as malnutrition, aspiration pneumonia, asphyxia, or even death from choking due to improper eating. Physical therapy offers a non-invasive treatment with high efficacy and low cost. Evidence supporting the use of physical therapy in dysphagia treatment is increasing, including techniques such as neuromuscular electrical stimulation, sensory stimulation, transcranial direct current stimulation, and repetitive transcranial magnetic stimulation. While initial studies have shown promising results, the effectiveness of specific treatment regimens still requires further validation. At present, there is a lack of scientific evidence to guide patient selection, develop appropriate treatment regimens, and accurately evaluate treatment outcomes. Therefore, the primary objectives of this review are to review the results of existing research, summarize the application of physical therapy in dysphagia management, we also discussed the mechanisms and treatments of physical therapy for neurogenic dysphagia.

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“…Post-stroke dysphagia (PSD) represents a prevalent complication, affecting an estimated 28% to 67% of stroke patients ( 4 ). Moreover, individuals with dysphagia following stroke often endure persistent swallowing difficulties, persisting up to six months post-onset ( 5 ). Neuromuscular Electrical stimulation (NMES), Pharyngeal electrical stimulation (PES) and modified Pharyngeal electrical stimulation (mPES), also have been reported as an effective treatment ( 6 , 7 ).…”

Section: Introductionmentioning

confidence: 99%

Clinical study on the efficacy of postural control combined with electroacupuncture in treating dysphagia after stroke

Wu,

Zhang,

et al. 2024

Front. Neurol.

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ObjectiveTo evaluate the clinical effectiveness of combining postural control with electroacupuncture in the treatment of dysphagia following stroke, with the goal of establishing a solid clinical foundation for this therapeutic approach and investigating potential mechanisms to stimulate additional research and progress in post-stroke dysphagia management.Methods138 patients who met the diagnostic and inclusion criteria were enrolled and divided into control group and observation group. Both groups received conventional rehabilitation training. Additionally, the control group received swallowing training and diet optimize, while the observation group received swallowing training, diet optimize, posture control as well as electroacupuncture therapy. After four weeks, swallowing function was assessed and compared between the two groups using the Standardized Swallowing Assessment (SSA) score and water swallowing test (WST).ResultsPatients who underwent postural control therapy in combination with electroacupuncture demonstrated significantly higher treatment efficacy compared to the control group. Notably, The SSA score and WST score in both groups decreased significantly, and the observation group showed more improvements in aspiration compared to the control group.ConclusionThe integration of posture control, electroacupuncture, and conventional rehabilitation training can effectively lower the degree of post-stroke swallowing disorders, restore swallowing function, and significantly reduce the occurrence of complications such as aspiration, fever, and nutritional disorders. Moreover, this approach significantly improves the quality of life of patients and is more effective than conventional rehabilitation training in treating post-stroke swallowing disorders.Clinical trial registrationhttps://www.chictr.org.cn/, Identifier ChiCTR2300075870.

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Effects of vitamin C stimulation on rehabilitation of dysphagia after stroke: a randomized trial

Cited by 8 publications

References 30 publications

Biomarkers associated with functional improvement after stroke rehabilitation: a systematic review and meta-analysis of randomized controlled trials

Biomarkers associated with functional improvement after stroke rehabilitation: a systematic review and meta-analysis of randomized controlled trials

The impact of physical therapy on dysphagia in neurological diseases: a review

Clinical study on the efficacy of postural control combined with electroacupuncture in treating dysphagia after stroke

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