Effects of vitamin C on dark circles of the lower eyelids: quantitative evaluation using image analysis and echogram

Abstract

ANa may improve DCLE by thickening the eyelid dermis and concealing dark coloration due to congested blood.

Clinical efficacy and safety of 20% glycolic peel, 15% lactic peel, and topical 20% vitamin C in constitutional type of periorbital melanosis: a comparative study

“…GA peel has not yet been used much for POM. Besides peels, topical vitamin C has also been used by earlier workers with good results in POM . However, there is paucity of studies in the literature comparing various therapeutic modalities for POM with regard to efficacy and safety till date.…”

“…Vitamin C and its derivatives, such as magnesium ascorbyl phosphate and ascorbic acid glucoside, have a long history as topical skin‐lightening agents . Vitamin C has two major functions: (1) it inhibits melanogenesis in human melanocytes, thus reducing melanin synthesis, and (2) it regulates the collagen synthesis, thus increasing the dermal collagen …”

Periorbital Hyperpigmentation in Asians: An Epidemiologic Study and a Proposed Classification

“…9,10 In another study by Oshima and colleagues, vitamin C was found to be effective in the treatment of POH by concealing vascular congestion by increasing dermal thickness. 11 As shown in our study, the vascular type of POH is the predominant type of POH in the Singaporean population and in particular among the Chinese. This observation may explain why skin lightening creams have often failed to produce results in Singapore.…”

Role of antioxidants in the skin: Anti-aging effects

“…Heller et al suggest that dark circles on the lower eyelid, which are caused by hyperpigmentation and poor blood circulation, are improved by ascorbic acid. In fact, in an in vivo study, ascorbic acid Na salt significantly improved dark circles due to effects on melanin, erythema, and dermal thickness [56]. These findings demonstrated the effects of ascorbic acid to suppress melanogenesis, to stabilize NOS, and to stimulate collagen synthesis.…”