Effects of vitamin B12 supplementation on cognition, depression, and fatigue in patients with lacunar stroke

Huijts, Marjolein; Oostenbrugge, Robert J. van; Rouhl, Rob P.W.; Menheere, P. P. C. A.; Duits, Annelien

doi:10.1017/s1041610212001925

Cited by 6 publications

(5 citation statements)

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“…After the removal of 448 duplicates, 1,465 citations were excluded for not meeting the criteria outlined above, based on information garnered from their abstracts. Out of the 39 full-text articles reviewed, 27 studies were excluded for not reporting data on depressive symptoms in lacunar stroke patients (Aharon-Peretz et al ., 2000; van der Flier et al ., 2005; Jokinen et al ., 2006; Ramos-Estebanez et al ., 2008; Staekenborg et al ., 2010; Teodorczuk et al ., 2010; Man et al ., 2011; van Norden et al ., 2011; Xiong et al ., 2011; Firbank et al ., 2012; Grool et al ., 2012; Soriano-Raya et al ., 2012; Troisi et al ., 2012; Ogawa et al ., 2013; van Norden et al ., 2013; Wolfson et al ., 2013), reporting on the same patients (Grool et al ., 2013), not reporting data in a usable format (O'Brien et al ., 2006; Jokinen et al ., 2009; Fu et al ., 2010; Lavretsky et al ., 2010; Huijts et al ., 2012; Huijts et al ., 2013; Brookes et al ., 2013), or using neuropathological rather than imaging diagnoses (Thomas et al ., 2003; Santos et al ., 2009a; 2010). The study characteristics and demographics are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Lacunar stroke, deep white matter disease and depression: a meta-analysis

Egeto

Fischer

Ismail

et al. 2014

Int. Psychogeriatr.

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The pooled group of patients with lacunar stroke and deep white matter disease appear to have a similar prevalence of depression compared to those with other types of cerebrovascular diseases. However, the small number of studies, heterogeneous comparison groups, and high statistical heterogeneity between studies posed an obstacle to the meta-analysis. To determine appropriate screening and treatment approaches, future research will need to separate lacunar stroke and deep white matter disease patients, and include larger sample sizes and healthy control groups to determine their distinct contributions to depression.

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Section: Resultsmentioning

confidence: 99%

Lacunar stroke, deep white matter disease and depression: a meta-analysis

Egeto

Fischer

Ismail

et al. 2014

Int. Psychogeriatr.

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“…One possible reason for the improvement of MMSE score with vitamin B 12 supplementation is the improvement in attention and mood [ 24 ]. Vitamin B 12 supplementation has also been reported to reduce the symptoms of depression [ 45 ], fatigue, delirium [ 46 ] and abnormalities in electroencephalography [ 47 ]. Other possible explanations include a practice effect due to the possibility of remembering the content of the test and a placebo effect.…”

Section: Discussionmentioning

confidence: 99%

Influences of Vitamin B12 Supplementation on Cognition and Homocysteine in Patients with Vitamin B12 Deficiency and Cognitive Impairment

et al. 2022

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Vitamin B12 deficiency is associated with cognitive impairment, hyperhomocysteinemia, and hippocampal atrophy. However, the recovery of cognition with vitamin B12 supplementation remains controversial. Of the 1716 patients who visited our outpatient clinic for dementia, 83 had vitamin B12 deficiency. Among these, 39 patients (mean age, 80.1 ± 8.2 years) had undergone Mini-Mental State Examination (MMSE) and laboratory tests for vitamin B12, homocysteine (Hcy), and folic acid levels. The hippocampal volume was estimated using the z-score of the MRI-voxel-based specific regional analysis system for Alzheimer’s disease. This is multi-center, open-label, single-arm study. All the 39 patients were administered vitamin B12 and underwent reassessment to measure the retested for MMSE and Hcy after 21−133 days (median = 56 days, interquartile range (IQR) = 43–79 days). After vitamin B12 supplementation, the mean MMSE score improved significantly from 20.5 ± 6.4 to 22.9 ± 5.5 (p < 0.001). Hcy level decreased significantly from 22.9 ± 16.9 nmol/mL to 11.5 ± 3.9 nmol/mL (p < 0.001). Significant correlation was detected between the extent of change in MMSE scores and baseline Hcy values. The degree of MMSE score was not correlated with hippocampal atrophy assessed by the z-score. While several other factors should be considered, vitamin B12 supplementation resulted in improved cognitive function, at least in the short term, in patients with vitamin B12 deficiency.

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“…Fatigue perception is greater in stroke patients with a lacunar infarct and B12 deficiency relative to those without ( P = 0.01) 114 suggesting an association between B12 deficiency and fatigue. However, B12 supplementation fails to improve fatigue symptoms in patients with a lacunar infarct 115 and in both IBD and IBS outpatients 116 suggesting B12 deficiency is not an aetiological factor in quiescent IBD fatigue.…”

Section: Factors Associated With Ibd Fatiguementioning

confidence: 99%

Review article: The aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies

McGing

Radford

Francis

et al. 2021

Aliment Pharmacol Ther

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Background: Fatigue is the inability to achieve or maintain an expected work output resulting from central or peripheral mechanisms. The prevalence of inflammatory bowel disease (IBD) fatigue can reach 86% in active disease, persisting in 50%-52% of patients with mild to inactive disease. Fatigue is the commonest reason for work absence in IBD, and patients often report fatigue burden to be greater than that of primary disease symptoms. Relatively few evidence-based treatment options exist, and the aetiology is poorly understood. Aim:To review the available data and suggest a possible aetiology of IBD fatigue and to consider the efficacy of existing management strategies and highlight potential future interventions. Methods:We reviewed fatigue-related literature in IBD using PubMed database. Results: Disease related factors such as inflammation and pharmacological treatments negatively impact skeletal muscle and brain physiology, likely contributing to fatigue symptoms. Secondary factors such as malnutrition, anaemia, sleep disturbance and psychological comorbidity are potential determinants. Immune profile, faecal microbiota composition and physical fitness differ significantly between fatigued and non-fatigued patients, suggesting these may be aetiological factors. Solution-focused therapy, high-dosage thiamine supplementation and biological therapy may reduce fatigue perception in IBD. The effect of physical activity interventions is inconclusive. Conclusions: A multimodal approach is likely required to treat IBD fatigue. Established reversible factors like anaemia, micronutrient deficiencies and active disease should initially be resolved. Psychosocial intervention shows potential efficacy in reducing fatigue perception in quiescent disease. Restoring physical deconditioning by exercise training intervention may further improve fatigue burden.| 369 MCGING et al.

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Effects of vitamin B12 supplementation on cognition, depression, and fatigue in patients with lacunar stroke

Abstract: We read the review by Moore et al. (2012), recently published in this journal, with great interest and compliment the authors for their thorough review of cognitive impairment and its relation to vitamin B12.

Cited by 6 publications

References 13 publications

Lacunar stroke, deep white matter disease and depression: a meta-analysis

Lacunar stroke, deep white matter disease and depression: a meta-analysis

Influences of Vitamin B12 Supplementation on Cognition and Homocysteine in Patients with Vitamin B12 Deficiency and Cognitive Impairment

Review article: The aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies

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