Effects of Vitamin A or Beta Carotene Supplementation on Pregnancy-Related Mortality and Infant Mortality in Rural Bangladesh

West, Keith P.; Christian, Parul; Labrique, Alain; Rashid, Mahbubur; Shamim, Abu Ahmed; Klemm, Rolf; Massie, Allan B.; Mehra, Sucheta; Schulze, Kerry; Ali, Hasmot; Ullah, Barkat; Wu, Lee; Katz, Joanne; Banu, Hashina Bilkish; Akhter, Halida H.; Sommer, Alfred

doi:10.1001/jama.2011.656

Cited by 124 publications

(148 citation statements)

References 26 publications

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“…Details of the trial were published elsewhere (16,17) . In brief, once enrolled in early pregnancy, a baseline interview was conducted to collect, among other information, demographic and socio-economic status as well as reproductive history.…”

Section: Methodsmentioning

confidence: 99%

Plasma zinc, vitamin B₁₂ and α-tocopherol are positively and plasma γ-tocopherol is negatively associated with Hb concentration in early pregnancy in north-west Bangladesh

Shamim

Kabir

Merrill

et al. 2013

Public Health Nutr.

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Objective: The objective of the current analysis was to explore the association of multiple micronutrients with Hb concentration among pregnant women in a South Asian setting, a topic that has not been adequately explored. Design: Sociodemographic, anthropometric and micronutrient status (plasma ferritin, transferrin receptor, retinol, a-and g-tocopherol, folate, vitamin B 12 , Zn) and Hb concentration were assessed at early pregnancy. Setting: The biochemical sub-study was nested within a double-blind, placebocontrolled, community-based vitamin A and b-carotene supplementation trial in rural north-western Bangladesh (JiVitA). All assessments were conducted before trial supplementation was initiated. Subjects: A systematic sample of 285 women was selected from those enrolled in the biochemical sub-study. Results: Seventeen per cent of women were mildly anaemic; moderate and severe anaemia was uncommon (2?1 %). a-Tocopherol, vitamin B 12 and Zn deficiencies were common (43?5 %, 19?7 % and 14?7 %, respectively); however, vitamin A, folate and Fe deficiencies were comparatively rare (7?4 %, 2?8 % and ,1 %, respectively). Plasma Zn, vitamin B 12 and a-tocopherol were positively associated and plasma g-tocopherol was negatively associated with Hb (P , 0?05) after adjustment for gestational age, inflammation status, season and nutritional status measured by mid-upper arm circumference. Conclusions: Among pregnant women in rural Bangladesh with minimal Fe deficiency, plasma Zn, vitamin B 12 , and a-and g-tocopherol concentrations were associated with Hb concentration. Appreciating the influence on Hb of micronutrients in addition to those with known associations with anaemia, such as Fe, folate, and vitamin A, is important when addressing anaemia in similar settings. Keywords Hb Tocopherol Zinc PregnancyThe global prevalence of anaemia among pregnant women, a demographic that experiences a disproportionately elevated risk, is estimated to be 42 % or more (1) . In Bangladesh, the most recent national survey from 1998 to 1999 showed that 49 % of pregnant women were anaemic, similar to the rate found in other studies and surveys across the country (2)(3)(4)

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Section: Methodsmentioning

confidence: 99%

Plasma zinc, vitamin B₁₂ and α-tocopherol are positively and plasma γ-tocopherol is negatively associated with Hb concentration in early pregnancy in north-west Bangladesh

Shamim

Kabir

Merrill

et al. 2013

Public Health Nutr.

Self Cite

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“…Supplementation of vitamin A during pregnancy in an undernourished population in Nepal has also been associated with improved offspring lung function [33], however; it did not decrease risk of asthma [34]. Supplementation of newborns with vitamin A in Bangladesh improved infant survival [35], however other studies have shown no effect of vitamin A supplementation on infant or maternal survival [36,37]. A 2016 birth cohort study was conducted to assess the effects of vitamin supplementation during pregnancy on child behavior.…”

Section: Vitamin a Compounds And Infant Feedingmentioning

confidence: 99%

Vitamin A and Related Compounds in the Prenatal and Postnatal States: A MaternalNeonate Focused Review

Wu¹,

Anderson‐Berry²,

Hanson³

2017

J Clin Nutr Diet

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Background: It is generally accepted that vitamin A is critical to fetal and infant development. However, vitamin A has many related compounds, including lutein, carotenes, and lycopene, and recent evidence has shown they may also be important in maternal-infant health. Much less is known about the impact of vitamin A related compounds on maternal and newborn outcomes. Methods:The following article presents a review of maternal vitamin A and related compounds on the fetus and newborn, particularly in the brain and retina. Dietary intake and supplementation will be examined in their relationship to breast milk and formula levels of vitamin A and related compounds. Finally, deficiencies in developed and developing countries are discussed.Results: Vitamin A related compounds, such as lycopene, carotenes, and lutein, may impact maternal-infant outcomes independent of retinol status. High-risk groups, including preterm infants, have been shown to be particularly susceptible. Studies also show that vitamin A deficiency remains a problem in developing nations and may be a concern in disadvantaged populations in developed nations. Conclusion:This review indicates a need to better understand the influence of maternal vitamin A and related compounds in order to improve interventions to maintain homeostatic levels in mothers and neonates.

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“…También se ha propuesto una posible protección de la piel frente a daños de la radiación solar 41 , una posible actividad reguladora sobre el sistema inmunológico en líneas celulares 60 , y la posible reducción de la adiposidad y tamaño de los adipocitos en ratones 61 . Además, se ha propuesto que el efecto antioxidante de los carotenoides de la dieta guarda relación con la protección de la degeneración macular tardía asociada a la edad 62 , así como un mejor desarrollo y crecimiento normal del embrión, atenuando la incidencia de parto prematuro 63 .…”

Section: Otros Carotenoidesunclassified

El tomate, ¿alimento saludable y/o funcional?

Navarro‐González

Periago

2016

Rev Esp Nutr Hum Diet

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Este trabajo es una revisión bibliográfica científica sobre la presencia de compuestos bioactivos en tomate y derivados y la función de estos compuestos para promover la salud del organismo humano. Diferentes estudios científicos muestran que el tomate o sus derivados tienen diferentes tipos de moléculas, algunas con actividad antioxidante, que actúan protegiendo a lípidos, lipoproteínas, ADN, etc. de los radicales libres generados por el organismo. Esta función podría ser una de las causantes de la aparente relación entre su consumo y la protección de enfermedades degenerativas y crónicas como el cáncer, enfermedades cardiovasculares, enfermedad de Parkinson, etc. Estudios más recientes han propuesto otros mecanismos bioquímicos por los cuales los componentes del tomate pueden ejercer esa función beneficiosa sobre la salud. Pero además de intentar conocer los efectos beneficiosos de los compuestos presentes en el tomate de forma aislada, algunos estudios científicos parecen indicar que el mayor beneficio de este alimento se debe al efecto sinérgico que existe entre todos sus compuestos. Y algunos estudios epidemiológicos asocian que su consumo asiduo tiene diferentes efectos beneficiosos sobre la salud. Debido a la relación existente entre los compuestos bioactivos del tomate, su consumo cotidiano y su efecto sobre la salud humana, el objetivo de la presente revisión bibliográfica es dar a conocer los compuestos presentes en este alimento y sus posibles acciones sobre la salud. PALABRAS CLAVE R E S U M E NEl tomate, ¿alimento saludable y/o funcional?

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Effects of Vitamin A or Beta Carotene Supplementation on Pregnancy-Related Mortality and Infant Mortality in Rural Bangladesh

Abstract: clinicaltrials.gov Identifier: NCT00198822.

Cited by 124 publications

References 26 publications

Plasma zinc, vitamin B₁₂ and α-tocopherol are positively and plasma γ-tocopherol is negatively associated with Hb concentration in early pregnancy in north-west Bangladesh

Plasma zinc, vitamin B₁₂ and α-tocopherol are positively and plasma γ-tocopherol is negatively associated with Hb concentration in early pregnancy in north-west Bangladesh

Vitamin A and Related Compounds in the Prenatal and Postnatal States: A MaternalNeonate Focused Review

El tomate, ¿alimento saludable y/o funcional?

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Effects of Vitamin A or Beta Carotene Supplementation on Pregnancy-Related Mortality and Infant Mortality in Rural Bangladesh

Abstract: clinicaltrials.gov Identifier: NCT00198822.

Cited by 124 publications

References 26 publications

Plasma zinc, vitamin B12 and α-tocopherol are positively and plasma γ-tocopherol is negatively associated with Hb concentration in early pregnancy in north-west Bangladesh

Plasma zinc, vitamin B12 and α-tocopherol are positively and plasma γ-tocopherol is negatively associated with Hb concentration in early pregnancy in north-west Bangladesh

Vitamin A and Related Compounds in the Prenatal and Postnatal States: A MaternalNeonate Focused Review

El tomate, ¿alimento saludable y/o funcional?

Contact Info

Product

Resources

About

Plasma zinc, vitamin B₁₂ and α-tocopherol are positively and plasma γ-tocopherol is negatively associated with Hb concentration in early pregnancy in north-west Bangladesh

Plasma zinc, vitamin B₁₂ and α-tocopherol are positively and plasma γ-tocopherol is negatively associated with Hb concentration in early pregnancy in north-west Bangladesh