Effects of visual attention modulation on dynamic functional connectivity during own-face viewing in body dysmorphic disorder

Wong, Wai Hing; Cabral, Joana; Rane, Riddhi; Ly, Ronald; Kringelbach, Morten L.; Feusner, Jamie D.

doi:10.1038/s41386-021-01039-w

Cited by 11 publications

(9 citation statements)

References 79 publications

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“…Subsequently, we examined, for each k , any PL state that significantly differed in probability between music listening and no music. We note that this methodological approach inherently assumes a common repertoire of PL states during rest and task, with task being characterized by a change in the relative probability of occurrence of the different states (Figueroa et al, 2019 ; Wong et al, 2021 ), and not by a single task‐specific FC state, as considered in other task studies (Gonzalez‐Castillo et al, 2015 ).…”

Section: Methodsmentioning

confidence: 99%

The early adolescent brain on music: Analysis of functional dynamics reveals engagement of orbitofrontal cortex reward system

Fasano

Cabral

Stevner

et al. 2022

Human Brain Mapping

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Music listening plays a pivotal role for children and adolescents, yet surprisingly few neuroimaging studies have studied the underlying functional dynamics. We used functional magnetic resonance imaging to scan 17 preadolescents aged 10-11 years old while listening to music. We subsequently tracked the occurrence of functional brain networks over time by using a recent method that detects recurrent BOLD phase-locking states: the Leading Eigenvector Dynamics Analysis (LEiDA). In particular, we compared the probabilities of occurrence and switching profiles of different patterns of BOLD phase-locking between music and no music. Moreover, we used an adapted version of the Barcelona Music Reward Questionnaire (BMRQ) to measure the music reward sensitivity of the participants. Our results showed significantly increased occurrence of a BOLD phase-locking pattern during music listening compared to no music, characterized by a phase-shift in the BOLD signals of the medial orbitofrontal and ventromedial prefrontal cortices -a brain subsystem associated to reward processing -from the rest of the brain. Moreover, we observed a significantly higher probability of switching to this pattern while listening to music. We also found a positive correlation between the individual musical reward sensitivity and the tendency to switch to this reward state during music.Our findings highlight the involvement of a brain subsystem involved in hedonic processing during music listening in the early adolescent brain. These results offer novel insight into the neural underpinnings of musical reward in early adolescence and may help us to understand the importance of music at this delicate age.

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Section: Methodsmentioning

confidence: 99%

The early adolescent brain on music: Analysis of functional dynamics reveals engagement of orbitofrontal cortex reward system

Fasano

Cabral

Stevner

et al. 2022

Human Brain Mapping

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“…LEiDA have been related to cognitive performance (Cabral et al, 2017), emotionality (Stark et al, 2020), depressive symptoms (Alonso Martínez, Deco, Ter Horst, and Cabral, 2020), trait self-reflectiveness (Larabi et al, 2020), body dysmorphic disorder (Wong et al, 2021) and distinct mood states in remitted MDD (rMDD) patients (Figueroa et al, 2019), which reinforces its sensitivity to both clinical and pre-clinical psychiatric symptoms.…”

Section: Introductionmentioning

confidence: 91%

“…In comparison to other analytical tools, LEiDA extends from measures of connectivity or correlation by considering also the phase-shifts between brain regions and describes discrete instead of overlapping states in time (Kringelbach and Deco, 2020). Dynamic characteristics of FC states derived from LEiDA have been related to cognitive performance (Cabral et al, 2017), emotionality (Stark et al, 2020), depressive symptoms (Alonso Martínez, Deco, Ter Horst, and Cabral, 2020), trait self-reflectiveness (Larabi et al, 2020), body dysmorphic disorder (Wong et al, 2021) and distinct mood states in remitted MDD (rMDD) patients (Figueroa et al, 2019), which reinforces its sensitivity to both clinical and pre-clinical psychiatric symptoms.…”

Section: Introductionmentioning

confidence: 99%

Segregation of dynamic resting-state reward, default mode and attentional networks after remitted patients transition into a recurrent depressive episode

Alonso

Tyborowska

Ikani

et al. 2022

Preprint

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Introduction: Recurrence in major depression disorder (MDD) is common, but neurobiological models capturing vulnerability for recurrences are scarce. Disturbances in multiple resting-state networks have been linked to MDD, but most approaches focus on stable (vs. dynamic) network characteristics. We investigated how the brain's dynamical repertoire changes after patients transition from remission to recurrence of a new depressive episode. Methods: Sixty drug-free, MDD-patients with more than 2 episodes underwent a baseline resting-state fMRI scan when in remission. Over 30-months follow-up, 11 patients with a recurrence and 17 matched-remitted MDD-patients without a recurrence underwent a second fMRI scan. Recurrent patterns of functional connectivity were characterized by applying leading eigenvector dynamics analysis (LEiDA). Differences between baseline and follow-up were identified for the 11 non-remitted patients, while data from the 17 matched-remitted patients was used as a validation dataset. Results: After the transition into a depressive state, the reward and a visuo-attentional networks were detected significantly more often, whereas default mode network activity was found to have a longer duration. Additionally, the fMRI signal in the areas underlying the reward network were significantly less synchronized with the rest of the brain after recurrence (compared to a state of remission). These changes were not observed in the matched-remitted patients who were scanned twice while in remission. Conclusion: These findings characterize the changes that are specifically associated with the transition from remission to recurrence and provide first evidence of increased segregation in the brain's dynamical repertoire when a recurrent depressive episode occurs.

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“…In this analytic framework, termed Leading Eigenvector Dynamics Analysis (LEiDA), RSNs are captured as recurrent modes of phase-locked synchronization of fMRI signals, which were found to overlap closely with RSNs from the literature (Lord et al, 2019;Vohryzek et al, 2020). An advantage of the method is that it allows calculation of the proportion of time points during an fMRI session assigned to a given RSN, providing a quantitative measure that can be statistically compared between conditions (Alonso Martínez et al, 2020;Cabral, Vidaurre, et al, 2017;Figueroa et al, 2019;Larabi et al, 2020;Magalhães et al, 2021;Wong et al, 2021). This approach allows detection of network-specific modulations; for example, a previous study using LEiDA revealed that psilocybin, a psychoactive molecule, selectively decreases the occupancy of the frontoparietal RSN (associated with executive control), leaving the occupancy of the other RSNs unchanged (Lord et al, 2019), while another study revealed the specific engagement of the orbitofrontal cortex reward system during music listening (Fasano et al, 2022).…”

Section: Dynamic Resting-state Network Analysismentioning

confidence: 99%

Modulation of limbic resting-state networks by subthalamic nucleus deep brain stimulation

Eraifej

Cabral

Fernandes

et al. 2023

Network Neuroscience

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Beyond the established effects of subthalamic nucleus deep brain stimulation (STN-DBS) in reducing motor symptoms in Parkinson’s disease, recent evidence has highlighted the effect on non-motor symptoms. However, the impact of STN-DBS on disseminated networks remains unclear. This study aimed to perform a quantitative evaluation of network-specific modulation induced by STN-DBS using Leading Eigenvector Dynamics Analysis (LEiDA). We calculated the occupancy of resting-state networks (RSNs) in functional MRI data from 10 patients with Parkinson’s disease implanted with STN-DBS and statistically compared between ON and OFF conditions. STN-DBS was found to specifically modulate the occupancy of networks overlapping with limbic RSNs. STN-DBS significantly increased the occupancy of an orbitofrontal limbic subsystem with respect to both DBS OFF(p = 0.0057) and 49 age-matched healthy controls (p = 0.0033). Occupancy of a diffuse limbic RSN was increased with STN-DBS OFF when compared to healthy controls (p = 0.021), but not when STN-DBS was ON, which indicates rebalancing of this network. These results highlight the modulatory effect of STN-DBS on components of the limbic system, particularly within the orbitofrontal cortex, a structure associated with reward processing. These results reinforce the value of quantitative biomarkers of RSN activity in evaluating the disseminated impact of brain stimulation techniques and the personalization of therapeutic strategies.

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Effects of visual attention modulation on dynamic functional connectivity during own-face viewing in body dysmorphic disorder

Cited by 11 publications

References 79 publications

The early adolescent brain on music: Analysis of functional dynamics reveals engagement of orbitofrontal cortex reward system

The early adolescent brain on music: Analysis of functional dynamics reveals engagement of orbitofrontal cortex reward system

Segregation of dynamic resting-state reward, default mode and attentional networks after remitted patients transition into a recurrent depressive episode

Modulation of limbic resting-state networks by subthalamic nucleus deep brain stimulation

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