Effects of Vesicoureteric Reflux on Renal Growth and Function as Measured by GFR, Plasma Creatinine and Urinary Concentrating Ability: An Experimental Study in the Minipig

Abstract

The influence of vesicoureteric reflux (VUR) on renal growth and function measured by glomerular filtration rate (GFR), plasma creatinine concentration and urinary concentrating ability has been examined in a simple one-kidney model in the growing minipig over a period of approximately 5 months. Animals with reflux in association with low voiding pressures and normal bladder function (n = 6 ) , as well as those with raised voiding pressures and abnormal bladder function (n = 5), were investigated together with appropriate non-refluxing controls (n = 12).

Effect of Unilateral Vesicoureteric Reflux on Renal Growth and the Uptake of 99mTc DMSA by the Kidney. An Experimental Study in the Minipig

“…The effect of left unilateral VUR on the growth of the kidneys was assessed from consideration of the weight of the left kidney relative to the total renal weight, in comparison with non-refluxing control animals. The validity of using weight as an index of growth was discussed previously (Ransley et al, 1987). By the end of the experimental period the individual kidneys had achieved a weight of between 60 and 80g.…”

“…In a recent experimental study using a 1-kidney pig model (Ransley et al, 1987) we were unable to demonstrate any effect of vesicoureteric reflux on renal growth or function measured by glomerular filtration rate (GFR). VUR was, however, associated with a small decrease in urinary concentrating ability.…”

“…Cr EDTA GFR and urinary concentrating ability were estimated as described previously (Ransley et al, 1984(Ransley et al, , 1987 at the intervals detailed ( Fig. 1B).…”

Ontogeny and Cross-species Comparison of Pathways Involved in Drug Absorption, Distribution, Metabolism, and Excretion in Neonates (Review): Kidney

“…Glomerular filtration rate values of 44-58 ml/min have been noted in minipigs at PNW 4, which corresponds to approximately 4.5-5 ml/min per kilogram. By PNW 15, GFR has increased to 101-116 ml/min, but as they have now grown significantly, the GFR value is down to 3-4 ml/min per kilogram, which is roughly similar to the dog on a BW basis (Ransley et al, 1987). For conventional pigs (Belgian landrace  large white), the GFR indexed to body surface area increased in GFR from 46.6 to 100.9 ml/ min per square meter from 8 days to 7 weeks of age (Gasthuys et al, 2017).…”