Effects of very weak magnetic fields on radical pair reformation

Adair, Robert K.

doi:10.1002/(sici)1521-186x(1999)20:4<255::aid-bem6>3.0.co;2-w

Cited by 58 publications

(40 citation statements)

References 12 publications

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“…Several in vitro and in vivo findings have indeed demonstrated the occurrence of oxidative damage in neuronal cells following ELF-MF exposure [15,[18][19][20][21]42]. All these lines of evidence support the hypothesis based on the Bradical pair system^ac-cording to which ELF-MF contribute to prolonging the lifetime of free radicals and increasing their concentration in living cells [15,17].…”

Section: Discussionmentioning

confidence: 99%

“…More recently, several reports indicate that occupational exposure to electromagnetic fields might be associated with an increased risk of neurodegenerative diseases, mainly Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS) [12][13][14][15]; however, the epidemiological evidence supporting an univocal association between PD and exposure to electromagnetic fields remains poor and controversial [15,16]. In this context, ELF-MF (between 1 Hz up to 100 kHz, originating from power lines and household appliances, as well as welding machines, induction heaters, and transport systems) has been the factor generating most attention in neurodegenerative etiopathogenesis, as the interaction between ELF-MF and biological systems directly involves oxidative stress, in particular through the radical-based mechanism [17]. The molecular feature potentially associating ELF-MF with neurodegeneration relies on the redox imbalance which they trigger in brain [15,[18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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Extremely Low Frequency Magnetic Field (ELF-MF) Exposure Sensitizes SH-SY5Y Cells to the Pro-Parkinson’s Disease Toxin MPP+

et al. 2015

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Parkinson's disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron loss, with an etiopathogenesis involving both genetic and environmental factors. The occupational/residential exposure to the electromagnetic fields has been recently associated with an increased risk of neurodegenerative diseases; it has been thus proposed that the extremely low frequency magnetic field (ELF-MF) may contribute to neurodegenerative etiopathogenesis, as its interaction with biological systems directly impairs redox homeostasis in specific areas of the brain. The molecular mechanisms elicited by ELF-MF, and their potential involvement in PD onset, still remain unclear. To this end, we set up a generator of ELF-MF able to stably and homogeneously reproduce environmental prolonged exposure to ELF-MF (50 Hz, 1 mT). Results obtained indicate that ELF-MF exposure alters cell response of SH-SY5Y cells to MPP(+). We demonstrate that ELF-MF does not affect per se survival, shape, and morphology of both proliferating and differentiated SH-SY5Y cells but significantly impairs redox homeostasis and thiol content, triggering an increase in protein carbonylation. As a result, toxicity of MPP(+), even at low doses, is highly enhanced in ELF-MF-exposed cells due to a significant increase in ROS levels, potentiation of oxidative damage, and induction of a caspase-dependent apoptosis. Pre-incubation with the thiol antioxidants N-acetyl-L-cysteine and GSH ethyl-ester significantly reduces the extent of oxidative damage and protects cells from death induced by the combined treatment ELF-MF/MPP(+). Taken overall, our results demonstrate the redox-based molecular interaction between ELF-MF and PD neurotoxins in vitro, and open a new scenario for defining the synergy of environmental factors in PD onset.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Extremely Low Frequency Magnetic Field (ELF-MF) Exposure Sensitizes SH-SY5Y Cells to the Pro-Parkinson’s Disease Toxin MPP+

et al. 2015

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“…However, many authors (Adair, 1999;Brocklehurst 2002;Brocklehurst and McLauchan 1996;Eveson et al 2000;Goodman et al 1995) believe that the effect of weak magnetic fields is mediated by generation of free radicals, which are known to considerably affect LS in populations.…”

Section: Discussionmentioning

confidence: 99%

Correlations of life-span variation parameters in 128 successive generations of Drosophila melanogaster with changes in atmospheric pressure and geomagnetic activity

2004

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Correlations between the parameters of life-span (LS) distribution of Drosophila melanogaster, including mean LS (MLS) and the time of 10 and 90% population mortality, and some geophysical parameters that are usually beyond the control of researchers dealing with laboratory cultures, including atmospheric pressure, solar activity indices (Wolf's sunspot numbers and 2,800-MHz radio flux), and geomagnetic activity (planetary index, K(p)), were studied. Geophysical data were obtained from free-access official web sites of the National Oceanic & Atmospheric Administration of the US Department of Commerce and the Institute of Terrestrial Magnetism and Radiowave Propagation of the Russian Academy of Sciences. The geophysical parameters were calculated only for the period corresponding to 10 days of preimaginal development of the flies from egg to imago. Canonical correlation analysis, calculation of the non-parametric Spearman rank-order correlation coefficients, and graphical data analysis were used. Highly significant correlations between parameters of LS distribution in males and females and environmental factors, such as the atmospheric pressure on the 4th and 5th day of development and geomagnetic activity indices (K(p)) on the 6th and 10th day of development were found, with correlation coefficients varying from 0.31 to 0.37 (P<0.02). Assuming a causal relationship between geophysical factors and LS, it may be hypothesized that energetically weak environmental factors determine the formation of LS oscillatory dynamics in laboratory populations. The possible mechanisms underlying the contribution of these environmental factors to the LS variation in successive generations are discussed.

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“…The earth's magnetic field is about 0.03 to 0.07 mT, which is a natural component of the environment for living organisms. Magnetic fields much weaker than the earth's field can affect living organisms through the chemical processes and effect on the radical pair recombination (23). A review by Belyavskaya suggested that prolonged exposure of plants to a weak magnetic field might cause different biological effects at the cellular, tissue and organ levels (24).…”

Section: Discussionmentioning

confidence: 99%

Effects of static and electromagnetic fields on human serum paraoxonase-1 activity in vitro

Abdi

2018

JBRMS

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Introduction: In recent years the relationship between electromagnetic fields and coronary artery disease is attracted a considerable attention. Low density lipoprotein (LDL) oxidation is the initial step in the development of atherosclerosis. Paraoxonase1 (PON1) protects LDL and High density lipoprotein (HDL) against oxidative processes, thus preventing the formation of atherogenic (oxidized-LDL) ox-LDL molecules. In this study we investigated the effects of static magnetic fields (SMFs) and extremely low frequency electromagnetic fields (ELFEMFs) on PON1 activity as one of the independent risk factors for cardiovascular disease. Materials and methods: Pooled serum sample of 20 healthy men were exposed to SMFs and EMFs flux densities of 0.125, 0.25, 0.5, 1, 2, 3 and 4 mT for 60, 120 and 180 minutes at 25°C and then PON1 activity was measured spectrophotometrically using paraoxon as substrate. Results: EMFs of 0.125-1 mT had no effect on PON1 activity. Exposure to magnetic flux density of 2 mT leads to a significant increase in PON1 activity in 1 hour (P <0.05). Magnetic flux density of 3 and 4 mT, after 1hour of exposure, lead to an increase of PON1 activity to 1.2% and 2.8%, respectively (P <0.01). Conclusion: PON1 activity is influenced by a variety of agents like environmental, pharmacological, and lifestyle factors as well as age and sex. According to the finding of this study ELF-EMFs can alternate the serum activity of PON1 in vitro. If this effect of EMFs on PON1 activity has proven in vivo, it can be considered as an effective factor in coronary artery disease.

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Effects of very weak magnetic fields on radical pair reformation

Cited by 58 publications

References 12 publications

Extremely Low Frequency Magnetic Field (ELF-MF) Exposure Sensitizes SH-SY5Y Cells to the Pro-Parkinson’s Disease Toxin MPP+

Extremely Low Frequency Magnetic Field (ELF-MF) Exposure Sensitizes SH-SY5Y Cells to the Pro-Parkinson’s Disease Toxin MPP+

Correlations of life-span variation parameters in 128 successive generations of Drosophila melanogaster with changes in atmospheric pressure and geomagnetic activity

Effects of static and electromagnetic fields on human serum paraoxonase-1 activity in vitro

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