Effects of vertical and side-alternating vibration training on fall risk factors and bone turnover in older people at risk of falls

Corrie, Heather; Brooke‐Wavell, Katherine; Mansfield, Neil J.; Cowley, Alison; Morris, Rob; Masud, Tahir

doi:10.1093/ageing/afu136

Cited by 37 publications

(58 citation statements)

References 32 publications

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“…Chronic whole body vibration training has been shown to reduce markers of bone resorption [20, 21] and increase markers of bone formation [22] in a variety of populations. In the present study, there was a small increase in osteocalcin (~10%) 24 h after WBV and no change in bone resorption markers.…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge only two studies have examined the acute effects of vibration training on bone turnover markers in adults but in both cases, VIB was performed prior to resistance training session, and therefore only the additive effects could be assessed. In both male [22] and female [23] participants, the addition of VIB training resulted in significant reductions in CTX concentration after the subsequent resistance training, but rather surprisingly bone resorption (serum Trap5b concentration) was significantly increased after VIB and resistance training in female participants. Bone formation (bone ALP) was not affected in either study, which is in contrast to the present study where VIB training alone did not alter bone resorption (CTX) but bone formation markers OC (all conditions) and P1NP (FG15 and FG60) were favorably affected.…”

Section: Discussionmentioning

confidence: 99%

“…These favorable adaptations in BMD must presumably occur as a consequence of bone formation exceeding the rate of bone resorption resulting in net gain of bone mineral. Chronic VIB training has been shown to either decrease C-terminal telopeptide of type 1 collagen (CTX-1), a marker of bone resorption in both postmenopausal women (vertical vibration 12 Hz and 0.5 mm, 0.3 g; [20]) and young men (side alternating vibration 18 Hz and 4 mm, 2.6 g, for 4 weeks increasing to 22 Hz and 4 mm, 3.8 g, for last four weeks [21]), or to increase N-terminal propeptide type I procollagen (P1NP), a marker of bone formation in elderly adults (side alternating vibration at 29.8 Hz 2.9 mm, 3.6 g, [22]). However, these chronic studies cannot distinguish whether these effects relate to a chronic change in bone turnover or accrual of a series of acute responses after each training session.…”

Section: Introductionmentioning

confidence: 99%

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Short Duration Small Sided Football and to a Lesser Extent Whole Body Vibration Exercise Induce Acute Changes in Markers of Bone Turnover

Bowtell

Jackman

Scott

et al. 2016

BioMed Research International

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We aimed to study whether short-duration vibration exercise or football sessions of two different durations acutely changed plasma markers of bone turnover and muscle strain. Inactive premenopausal women (n = 56) were randomized to complete a single bout of short (FG15) or long duration (FG60) small sided football or low magnitude whole body vibration training (VIB). Procollagen type 1 amino-terminal propeptide (P1NP) was increased during exercise for FG15 (51.6 ± 23.0 to 56.5 ± 22.5 μg·L−1, mean ± SD, P < 0.05) and FG60 (42.6 ± 11.8 to 50.2 ± 12.8 μg·L−1, P < 0.05) but not for VIB (38.8 ± 15.1 to 36.6 ± 14.7 μg·L−1, P > 0.05). An increase in osteocalcin was observed 48 h after exercise (P < 0.05), which did not differ between exercise groups. C-terminal telopeptide of type 1 collagen was not affected by exercise. Blood lactate concentration increased during exercise for FG15 (0.6 ± 0.2 to 3.4 ± 1.2 mM) and FG60 (0.6 ± 0.2 to 3.3 ± 2.0 mM), but not for VIB (0.6 ± 0.2 to 0.8 ± 0.4 mM) (P < 0.05). Plasma creatine kinase increased by 55 ± 63% and 137 ± 119% 48 h after FG15 and FG60 (P < 0.05), but not after VIB (26 ± 54%, NS). In contrast to the minor elevation in osteocalcin in response to a single session of vibration exercise, both short and longer durations of small sided football acutely increased plasma P1NP, osteocalcin, and creatine kinase. This may contribute to favorable effects of chronic training on musculoskeletal health.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Short Duration Small Sided Football and to a Lesser Extent Whole Body Vibration Exercise Induce Acute Changes in Markers of Bone Turnover

Bowtell

Jackman

Scott

et al. 2016

BioMed Research International

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“…Although three previously published studies provided evidence of a significant therapeutic effect of vertical WBV on the TUG performance in elderly individuals (Bautmans et al, 2005;Bogaerts et al, 2011;Machado et al, 2010), recent studies did not report a significant effect on the same outcome, when WBV was compared to a no-training control group (Santin-Medeiros et al, 2015), an identical training program without WBV (Avelar et al, 2011;Corrie et al, 2015;Sitjà-Rabert et al, 2015), or a home balance exercise program (Sucuoglu et al, 2015). Four studies specifically evaluated the effect of vertical WBV on the BBS and Tinetti Balance Assessment and only Sucuoglu et al (2015) reported positive effects (Bautmans et al, 2005;Santin-Medeiros et al, 2015;Avelar et al, 2011;Sucuoglu et al, 2015).…”

Section: Lack Of Significant Effect Of Wbvmentioning

confidence: 99%

Effects of adding whole‐body vibration to routine day activity program on physical functioning in elderly with mild or moderate dementia: a randomized controlled trial

Lam

Liao

Kwok

et al. 2017

Int J Geriat Psychiatry

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Objective: To evaluate the effects of whole-body vibration (WBV) added to a routine activity program on lower limb strength, balance, and mobility among community-dwelling individuals with mild or moderate dementia, compared with the routine program alone. Methods: Fifty-four older adults (40 women; mean (SD) age: 79.8 (6.1) years) with mild or moderate dementia were recruited from two daycare centers. The participants were randomly allocated to undergo a routine day activity program combined with WBV training (WBV at 30 Hz, 2-mm peakto-peak amplitude) or the routine program only without WBV for 9 weeks (18 sessions). The primary outcome was functional mobility, measured using the timed up-and-go test. The following secondary outcomes were evaluated: Berg Balance Scale, Tinetti balance assessment, time to complete 5 repetitions of sit-to-stand, Quality of Life in Alzheimer's disease questionnaire, and Activities-specific Balance Confidence scale. The attendance rate and incidence of adverse events were also recorded. Results: The attendance rate for the training was high (86.0%). The incidence of adverse events was low, with only two of the 27 participants in the WBV group reporting mild knee pain. While significant improvement in timed up-and-go, Berg Balance Scale, and Tinetti balance score was found in both groups, none of the outcomes demonstrated a significant group by time interaction. Conclusions: WBV training is feasible and safe to use with people with mild or moderate dementia. However, it did not lead to further improvement in physical function and quality of life than the usual activity program provided at the daycare centers.

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“…High levels of biochemical markers of bone turnover in a patient with osteoporosis should lead to further investigation of other causes of low bone mass or fracture as osteoporosis is not generally characterized by high bone turnover, except in early postmenopausal women whose bone turnover often is high. Where the responsiveness of bone turnover markers to many different factors makes them less good at predicting long‐term outcomes such as fractures, it makes them better for monitoring interventions—pharmacological and to some extent nonpharmacological . Bone resorption markers and subsequently bone formation markers respond quickly to antiresorptive therapy and remain suppressed during effective antiresorptive therapy.…”

mentioning

confidence: 99%

Is There a Place for Bone Turnover Markers in the Management of Osteoporosis?

Langdahl

2018

Journal of Bone and Mineral Research

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A personalized approach to the diagnosis and treatment of osteoporosis requires the reliable estimation of future fracture risk as this will allow us to direct treatment to the patients who are most likely to benefit from the treatment. Although BMD is a good predictor of future fracture risk, it is not perfect. Many patients suffer fragility fractures at osteopenic or even normal BMD. There is, therefore, a need to improve fracture risk prediction for the individual patient. Several fracture risk assessment tools have been developed over the last two decades; they incorporate clinical risk factors in the fracture risk assessment-this has improved the risk assessment somewhat. Other aspects of bone quality have been added to the assessment armamentarium; for example, trabecular bone score provides information about microarchitecture and has been shown to improve fracture risk prediction. Bone turnover also influences bone quality and strength by destabilizing the trabecular network and inducing cortical porosity. Bone turnover can be assessed in many ways: from invasive bone biopsies to a fasting blood sample in which biochemical markers of bone turnover can be measured. Many studies over the last three decades have investigated the ability of various bone turnover markers to predict future fracture risk. The outcomes of these studies have been variable: Some found bone turnover markers to predict future fracture risk, but many did not. The most recent of these studies is reported in this issue of the Journal of Bone and Mineral Research. Crandall and colleagues report a nested case-control analysis of the predictive value of bone turnover markers for hip fracture in women participating in the Women's Health Initiative (WHI) study. They measured s-PINP and s-CTX at inclusion in the WHI study and identified 400 women, who suffered a fragility hip fracture between August 1994 and August 2004, and 400 control subjects without a hip fracture matched for age, race/ethnicity, and date of inclusion. The average follow-up period was a little over 7 years. Baseline levels of the two markers were not different between the cases and controls, and neither of the markers predicted incident hip fractures.(1) These findings are in accordance with the majority of studies investigating the predictive value of bone turnover markers for risk of future hip fractures. The most cited exception is the EPIDemiology of OSteoporosis (EPIDOS) study, (2) where an association was found between s-CTX and incident hip fracture.Important differences between the study by Crandall et al. and the EPIDOS study include age differences, the duration of followup, and adjustments for other relevant covariates. An analysis from the Rotterdam study demonstrated that an association between urinary-free deoxypyridinoline and incident hip fracture disappeared after correction for disability. Why are the results of these studies and the meta-analyses of these studies (4) conflicting? Bone turnover markers are different from BMD or TBS and most other aspects...

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Effects of vertical and side-alternating vibration training on fall risk factors and bone turnover in older people at risk of falls

Abstract: whole-body vibration increased leg power and bone formation, but it did not provide any additional benefits to balance or fall risk factors beyond a falls prevention programme in older people at risk of falls.

Cited by 37 publications

References 32 publications

Short Duration Small Sided Football and to a Lesser Extent Whole Body Vibration Exercise Induce Acute Changes in Markers of Bone Turnover

Short Duration Small Sided Football and to a Lesser Extent Whole Body Vibration Exercise Induce Acute Changes in Markers of Bone Turnover

Effects of adding whole‐body vibration to routine day activity program on physical functioning in elderly with mild or moderate dementia: a randomized controlled trial

Is There a Place for Bone Turnover Markers in the Management of Osteoporosis?

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