Effects of ventricular pacing-induced tachycardia on aortic mechanics in man

Stefanadis, Christodoulos; Dernellis, John; Vavuranakis, Manolis; Tsiamis, Eleftherios; Vlachopoulos, Charalambos; Toutouzas, Konstantinos; Diamandopoulos, Leonidas; Pitsavos, Christos; Toutouzas, Pavlos

doi:10.1016/s0008-6363(98)00115-1

Cited by 59 publications

(61 citation statements)

References 15 publications

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“…It should be noted, however, that the reproducibility of Tr has been reported to be fair to good (ICC: 0.43-0.84) 2, 13, 14) , and, given the low sample size of the two aforementioned studies (n = 20 and 22, respectively), these findings must be interpreted with caution. Stefanadis et al (1998) reported reduced local aortic stiffness and increased distensibility during incremental ventricular pacing 35) , which stands in further contrast to the results of similar or increased stiffness reported by Wilkinson 10, 11) and Lantelme 34) . Conversely, an observational study (n = 253) reported that a high HR is strongly associated with reduced carotid artery distension and an elevated aortic pulse wave velocity, even after adjusting for age and blood pressure 36) .…”

Section: Variables Influencing the Aixmentioning

confidence: 60%

Should the Augmentation Index be Normalized to Heart Rate?

Stoner

Faulkner

Lowe

et al. 2014

JAT

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Pulse wave analysis (PWA) is widely used to investigate systemic arterial stiffness. The augmentation index (AIx), the primary outcome derived from PWA, is influenced by the mean arterial pressure (MAP), age, gender and heart rate (HR). Gender-and age-specific reference values have been devised, and it is recommended that the MAP be used as a statistical covariate. The AIx is also commonly statistically adjusted to a HR of 75 b·min; however, this approach may be physiologically and statistically inappropriate. First, there appears to be an important physiological chronic interaction between HR and arterial stiffness. Second, the method used to correct to HR assumes that the relationship with AIx is uniform across populations. A more appropriate practice may be to include HR as an independent predictor or covariate; this approach is particularly recommended for longitudinal studies, in which changes in HR may help to explain changes in arterial stiffness.

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Section: Variables Influencing the Aixmentioning

confidence: 60%

Should the Augmentation Index be Normalized to Heart Rate?

Stoner

Faulkner

Lowe

et al. 2014

JAT

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“…[40][41][42] There was also a contradictory study showing reduced aortic stiffness and increased distensibility during incremental pacing. 43 Therefore, in order to clarify the relationship between arterial distensibility and heart rate, and its pathophysiology, further specific studies are necessary.…”

Section: Discussionmentioning

confidence: 99%

Relationship between blood pressure parameters and pulse wave velocity in normotensive and hypertensive subjects: invasive study

et al. 2006

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Blood pressure (BP) is one of the most important contributing factors to pulse wave velocity (PWV), a classic measure of arterial stiffness. Although there have been many non-invasive studies to show the relation between arterial stiffness and BP, the results are controversial. The aim of this study is to evaluate the role of BP as an influencing factor on PWV using invasive method. We observed 174 normotensive and untreated hypertensive subjects using coronary angiography. Arterial stiffness was assessed through aorto-femoral PWV by foot-to-foot velocity method using fluid-filled system. And BP was measured by pressure wave at the right common femoral artery. From univariate analysis, age, diabetes mellitus (DM), hypertension, waist, waist-to-hip ratio, total cholesterol-tohigh-density lipoprotein cholesterol ratio, systolic BP (SBP), pulse pressure (PP) and mean arterial pressure (MAP) showed significant association with PWV. To avoid multiple colinearity among SBP, PP and MAP, we performed multiple regression analysis predicting PWV thrice. Age, DM and each BP were significantly and consistently correlated to PWV. In the first and third modules, compared to age, SBP and MAP were less strong predictors, respectively. However, PP was the stronger predictor than age and DM in the second module. Lastly, we simultaneously forced MAP and PP with other variables in the fourth multivariate analysis. Age, DM and PP remained significantly correlated with PWV, but the significance of MAP was lost. This is the first invasive study to suggest that PP has the strongest correlation with PWV among a variety of BP parameters.

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“…Of note, the effects of heart rate manipulation reported by Morelli et al [2] differed from data observed in middle-aged healthy individuals [8]. Using central measurements of aortic pressure and volumetric catheters to determine aortic volume, Stefanadis et al [8] observed that pacing did not affect MAP, decreased systolic blood pressure while diastolic pressure was increased, and decreased the augmented pressure (the difference between central and peripheral systolic pressure).…”

mentioning

confidence: 92%

“…Using central measurements of aortic pressure and volumetric catheters to determine aortic volume, Stefanadis et al [8] observed that pacing did not affect MAP, decreased systolic blood pressure while diastolic pressure was increased, and decreased the augmented pressure (the difference between central and peripheral systolic pressure). Interestingly, distensibility of the aorta increased and stiffness index decreased at high HR, indicating that Ea should decrease at high HR.…”

mentioning

confidence: 99%