Effects of venlafaxine on ethanol withdrawal syndrome in rats

Sağlam, Esra; Uzbay, I.T.; Kayır, Hakan; Çelik, Turgay; Beyazyürek, Mansur

doi:10.1111/j.1472-8206.2004.00281.x

Cited by 19 publications

(17 citation statements)

References 38 publications

(55 reference statements)

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“…Consistent with the previous findings on the same model [23,25,[29][30][31] the present data demonstrated that daily ethanol consumption above 11 g/kg for 15 consecutive days produced physical dependence in rats. At doses of 25, 50, and 100 mg/kg, HPE blocked both locomotor hyperactivity and stereotyped behaviors especially at 2 and 6 h of ethanol withdrawal.…”

Section: Discussionsupporting

confidence: 93%

“…Antidepressant drugs are mainly indicated in the ethanol withdrawal and the treatment of combined psychiatric disorders [20,21]. Recent studies from our laboratory also indicated that antidepressant agents attenuated some signs of ethanol withdrawal in rats [22][23][24]. These findings implied that antidepressant agents might be useful in the treatment of ethanol withdrawal syndrome in rats.…”

Section: Introductionmentioning

confidence: 81%

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Attenuation of ethanol withdrawal syndrome by extract of Hypericum perforatum in Wistar rats

Coşkun

Uzbay

Öztürk

et al. 2006

Fundamemntal Clinical Pharma

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The effects of Hypericum perforatum (St John's wort) on ethanol withdrawal syndrome have been investigated in ethanol-dependent rats. Adult male Wistar rats were subjects. Ethanol (7.2% v/v) was given to rats by a liquid diet for 15 days. Hypericum perforatum extract (HPE) (25-200 mg/kg) and saline were injected to rats intraperitoneally just before ethanol withdrawal. After second, fourth and sixth hour of ethanol withdrawal, rats were observed for 5 min, and withdrawal signs that included locomotor hyperactivity, stereotyped behavior and tremors were recorded or rated. A second series of injections was given at 6 h after the first one, and subjects were then tested for audiogenic seizures. HPE (25-200 mg/kg) produced some dose-dependent and significant inhibitory effects on locomotor hyperactivity at second and sixth hour of ethanol withdrawal. In addition, it significantly reduced the number of stereotyped behaviors at the same dose range. HPE (50 and 100 mg/kg) produced some significant inhibitory effects on tremor and audiogenic seizures during withdrawal period. These results suggest that HPE has some beneficial effects on ethanol withdrawal syndrome in rats.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 81%

Attenuation of ethanol withdrawal syndrome by extract of Hypericum perforatum in Wistar rats

Coşkun

Uzbay

Öztürk

et al. 2006

Fundamemntal Clinical Pharma

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“…Similarly, β1/2-AR antagonists have been used clinically to treat anxiety associated with alcohol withdrawal (Bailly et al, 1992; Sellers et al, 1977), and decrease operant responding for ethanol in a rodent model of dependence (Gilpin and Koob, 2010). SNRIs have shown promise in reducing anxiety-related alcohol intake, reportedly lessening alcohol craving and anxiety following withdrawal in clinical populations (Kim et al, 2005; Liappas et al, 2005; Petrakis et al, 2012) and likewise attenuating anxiety-like behavior, ethanol drinking and the symptoms of acute withdrawal in rodents (Ji et al, 2008; Mochizuki et al, 2002; Saglam et al, 2004; Simon O’Brien et al, 2011). Furthermore, we recently reported that prazosin and duloxetine, when delivered chronically, decrease home-cage ethanol intake and anxiety-like behavior in rats displaying relatively high levels of antecedent anxiety (Skelly and Weiner, 2014).…”

Section: Discussionmentioning

confidence: 99%

Adolescent social isolation increases anxiety-like behavior and ethanol intake and impairs fear extinction in adulthood: Possible role of disrupted noradrenergic signaling

et al. 2015

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Alcohol use disorder, anxiety disorders, and post-traumatic stress disorder (PTSD) are highly comorbid, and exposure to chronic stress during adolescence may increase the incidence of these conditions in adulthood. Efforts to identify the common stress-related mechanisms driving these disorders have been hampered, in part, by a lack of reliable preclinical models that replicate their comorbid symptomatology. Prior work by us, and others, has shown that adolescent social isolation increases anxiety-like behaviors and voluntary ethanol consumption in adult male Long-Evans rats. Here we examined whether social isolation also produces deficiencies in extinction of conditioned fear, a hallmark symptom of PTSD. Additionally, as disrupted noradrenergic signaling may contribute to alcoholism, we examined the effect of anxiolytic medications that target noradrenergic signaling on ethanol intake following adolescent social isolation. Our results confirm and extend previous findings that adolescent social isolation increases anxiety-like behavior and enhances ethanol intake and preference in adulthood. Additionally, social isolation is associated with a significant deficit in the extinction of conditioned fear and a marked increase in the ability of noradrenergic therapeutics to decrease ethanol intake. These results suggest that adolescent social isolation not only leads to persistent increases in anxiety-like behaviors and ethanol consumption, but also disrupts fear extinction, and as such may be a useful preclinical model of stress-related psychopathology. Our data also suggest that disrupted noradrenergic signaling may contribute to escalated ethanol drinking following social isolation, thus further highlighting the potential utility of noradrenergic therapeutics in treating the deleterious behavioral sequelae associated with early life stress.

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“…) and likewise attenuating ethanol self‐administration and the symptoms of acute withdrawal in rodents (Saglam et al. ; Ji et al. ; Simon O'Brien et al.…”

Section: Introductionmentioning

confidence: 99%

Chronic treatment with prazosin or duloxetine lessens concurrent anxiety‐like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety‐related alcohol use

Skelly

Weiner

2014

Brain and Behavior

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BackgroundAlcohol use disorders have been linked to increased anxiety, and enhanced central noradrenergic signaling may partly explain this relationship. Pharmacological interventions believed to reduce the excitatory effects of norepinephrine have proven effective in attenuating ethanol intake in alcoholics as well as in rodent models of ethanol dependence. However, most preclinical investigations into the effectiveness of these drugs in decreasing ethanol intake have been limited to acute observations, and none have concurrently assessed their anxiolytic effects. The purpose of these studies was to examine the long-term effectiveness of pharmacological interventions presumed to decrease norepinephrine signaling on concomitant ethanol self-administration and anxiety-like behavior in adult rats with relatively high levels of antecedent anxiety-like behavior.MethodsAdult male Long-Evans rats self-administered ethanol on an intermittent access schedule for eight to ten weeks prior to being implanted with osmotic minipumps containing either an a1-adrenoreceptor antagonist (prazosin, 1.5 mg/kg/day), a β1/2-adrenoreceptor antagonist (propranolol, 2.5 mg/kg/day), a serotonin/norepinephrine reuptake inhibitor (duloxetine, 1.5 mg/kg/day) or vehicle (10% dimethyl sulfoxide). These drugs were continuously delivered across four weeks, during which animals continued to have intermittent access to ethanol. Anxiety-like behavior was assessed on the elevated plus maze before treatment and again near the end of the drug delivery period.ResultsOur results indicate that chronic treatment with a low dose of prazosin or duloxetine significantly decreases ethanol self-administration (P < 0.05). Furthermore, this decrease in drinking is accompanied by significant reductions in the expression of anxiety-like behavior (P < 0.05).ConclusionsThese findings suggest that chronic treatment with putative inhibitors of central noradrenergic signaling may attenuate ethanol intake via a reduction in anxiety-like behavior.

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Effects of venlafaxine on ethanol withdrawal syndrome in rats

Cited by 19 publications

References 38 publications

Attenuation of ethanol withdrawal syndrome by extract of Hypericum perforatum in Wistar rats

Attenuation of ethanol withdrawal syndrome by extract of Hypericum perforatum in Wistar rats

Adolescent social isolation increases anxiety-like behavior and ethanol intake and impairs fear extinction in adulthood: Possible role of disrupted noradrenergic signaling

Chronic treatment with prazosin or duloxetine lessens concurrent anxiety‐like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety‐related alcohol use

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