Effects of Vasopressin on Human Memory Functions

Weingartner, Herbert; Gold, Philip W.; Ballenger, James C.; Smallberg, Sheila A.; Summers, Richard L.; Rubinow, David R.; Post, Robert M.; Goodwin, Frederick K.

doi:10.1097/00006254-198201000-00013

Cited by 17 publications

(24 citation statements)

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“…The conservation of V 1a receptor binding sites in many limbic structures in the rhesus brain suggests that V 1a receptors may be important for processing multimodal signals in primates as well. Several studies have suggested a potential role for vasopressin on memory processes in humans ( 27–29). There is a striking distribution of V 1a receptors in regions considered to be critical for mnemonic processing, such as the entorhinal cortex, presubiculum, and mamillary bodies.…”

Section: Discussionmentioning

confidence: 99%

Localization of Vasopressin (V_1a) Receptor Binding and mRNA in the Rhesus Monkey Brain

Young

Toloczko

Insel

1999

J Neuroendocrinology

122

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Centrally released arginine vasopressin (AVP) has been associated with various behavioural and cognitive effects, such as scent marking, aggression, and memory, which are believed to be mediated by the V1a subtype of the vasopressin receptor. Although the distribution of V1a receptors is conserved in a few brain regions, the pattern of expression of this receptor is, in general, highly species-specific. We have used receptor autoradiography with the linear V1a receptor ligand (125I-Phenylacetyl-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-Tyr-NH2) to characterize the pattern of receptor binding in the rhesus monkey brain. Brain sites of V1a receptor synthesis were defined using in-situ hybridization. The regions of highest V1a receptor density included the prefrontal, cingulate, pyriform, and entorhinal cortex, as well as the presubiculum and mamillary bodies. In addition, V1a receptor binding and mRNA were detected in several regions reported to have V1a receptor in most rodents, including the amygdala, bed nucleus of the stria terminalis, lateral septum, hypothalamus and the brainstem. The distribution is consistent with a role for vasopressin in higher cognitive functions, especially memory, in primates.

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Section: Discussionmentioning

confidence: 99%

Localization of Vasopressin (V_1a) Receptor Binding and mRNA in the Rhesus Monkey Brain

Young

Toloczko

Insel

1999

J Neuroendocrinology

122

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“…Weingartener, Gold, and Ballenger (1981) conducted a series of tests of memory in depressed patients. They found that depressed patients did not show stronger memory performance on semantic tasks than in their recall of acoustically processed words without semantic context.…”

Section: Attentional Disturbancementioning

confidence: 99%

The Neuropsychology of Attention

Cohen

1993

Critical Issues in Neuropsychology

210

118

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A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher.Originally published by Plenum Press, New York in 1993 Softcover reprint of the hardcover 1st edition 1993All rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher An unfortunate case of "hemispatial" inattention. ("M Babinet prevenu par sa portiere de Ia visite de Ia comete." From Le Charivari, 1858, by Honore Daumier. Babcock Bequest; Courtesy of Museum of Fine Arts, Boston, Massachusetts.) PrefaceAt the beginning of this project, I was struck by several paradoxes regarding the study of attentional phenomena within neuropsychology. On one hand, the concept of attention has been central to the historical development of psychology. Attention was considered a fundamental and inescapable aspect of human experience by Wilhelm Wundt, William James, and the other founders of modern psychology. On the other hand, for much of the 20th century, psychologists tried desperately to avoid acknowledging the need for an attentional construct. Because attention has an intangible quality and cannot be specified as a unitary process, many behavioral scientists considered the construct of attention theoretically incoherent. Some of their concerns regarding the nature of attentional phenomena were clearly justified. It is also apparent, however, that explanations of behavior and cognition that fail to account for attentional phenomena cannot fully capture human experience.Recently, there has been a shift in zeitgeist, and attention has received more favorable treatment within the cognitive neurosciences. Humans cannot handle an infinite amount of simultaneous information. Therefore, cognitive processes must exist that direct our focus to information that is important, and that permit the selection of stimuli and responses from the large universe of alternatives. Regardless of whether one advocates the existence of a discrete attentional process, it is necessary to account for the occurrence of those phenomena that we normally label as aspects of attention. Consideration of the mechanisms underlying the selection of information and the control of stimulus and response processes is critical if we hope to understand human cognitive experience.The necessity of studying the mechanisms underlying attentional phenomena is particularly evident within neuropsychology. Patients with brain disorders frequently do not perform at optimal levels, even when task variables are held constant. They may fail to detect an object in the environment, even though it can be demonstrated that they have adequate perceptual capability. Reference to performance deficits stemming from attentional dysfunction is common in cl...

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“…V 1A receptors have been shown to be present in vascular smooth muscle cells, hepatocytes, platelets, mesangial cells, cardiomyocytes, brain, testis, adrenal glands, spinal cord, sympathetic ganglia by radioligand binding techniques. These receptors serve to mediate the contraction, proliferation and hypertrophy of cells; platelet aggregation, hepatocyte glycogenosis; enhancement of learning and memory and steroid secretion (Weingartner et al , 1981; Thibonnier & Roberts, 1985; Jard et al , 1987; Phillips et al , 1990; Howl et al , 1991; Guillon et al , 1995; Serradeil‐Le Gal et al , 1995; Tahara et al , 1997a; 1998). V 1B receptors are located in the anterior pituitary, β‐cells of pancreas and adrenal medulla where they stimulate corticotropin, insulin and catecholamine release, respectively (Jard et al , 1986; Lee et al , 1995; Grazzini et al , 1996).…”

Section: Introductionmentioning

confidence: 99%

Pharmacological characterization of the human vasopressin receptor subtypes stably expressed in Chinese hamster ovary cells

Tahara¹,

Saito²,

Sugimoto³

et al. 1998

British J Pharmacology

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1 Three subtypes of human (h) arginine vasopressin (AVP) receptors, hV 1A , hV 1B and hV 2 , were stably expressed in Chinese hamster ovary (CHO) ] i or cyclic AMP response was similar to that observed in radioligand binding assays. 5 In conclusion, we have characterized the pharmacology of human cloned V 1A , V 1B and V 2 receptors and used these to determine the anity, selectivity and potency of nonpeptide AVP receptor antagonists. Thus they may prove to be a valuable tool in further examination of the physiological and pathophysiological roles of AVP.

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Effects of Vasopressin on Human Memory Functions

Cited by 17 publications

References 0 publications

Localization of Vasopressin (V_1a) Receptor Binding and mRNA in the Rhesus Monkey Brain

Localization of Vasopressin (V_1a) Receptor Binding and mRNA in the Rhesus Monkey Brain

The Neuropsychology of Attention

Pharmacological characterization of the human vasopressin receptor subtypes stably expressed in Chinese hamster ovary cells

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Effects of Vasopressin on Human Memory Functions

Cited by 17 publications

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Localization of Vasopressin (V1a) Receptor Binding and mRNA in the Rhesus Monkey Brain

Localization of Vasopressin (V1a) Receptor Binding and mRNA in the Rhesus Monkey Brain

The Neuropsychology of Attention

Pharmacological characterization of the human vasopressin receptor subtypes stably expressed in Chinese hamster ovary cells

Contact Info

Product

Resources

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Localization of Vasopressin (V_1a) Receptor Binding and mRNA in the Rhesus Monkey Brain

Localization of Vasopressin (V_1a) Receptor Binding and mRNA in the Rhesus Monkey Brain